Latest preprint reviews

  1. Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation

    This article has 13 authors:
    1. Simone Margaard Offersen
    2. Signe Adamberg
    3. Malene Roed Spiegelhauer
    4. Xiaotian Mao
    5. Torben Sølbeck Rasmussen
    6. Frej Larsen
    7. Jingren Zhong
    8. Duc Ninh Nguyen
    9. Dennis Sandris Nielsen
    10. Lise Aunsholt
    11. Thomas Thymann
    12. Kaarel Adamberg
    13. Anders Brunse
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors report on an innovative chemostat propagation system to reduce eukaryotic viruses while retaining phages in mixtures used for FVTs (fecal virome transplant). The authors hypothesized that chemostat-propagated viromes could modulate the gut microbiota and reduce necrotizing enterocolitis (NEC) lesions while avoiding potential side effects, such as earlier onset of diarrhea. Although no effect on NEC could be demonstrated, the revised document addressed the other concerns and is much improved from its original version. The study is convincing in that it integrates in vitro fermentation, high-resolution metagenomics, immunogenicity assays, and in vivo validation, demonstrating the potential of FVT using eukaryotic-free virome-based therapeutics.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. A theory of brain-computer interface learning via low-dimensional control

    This article has 9 authors:
    1. Jorge A Menéndez
    2. Jay A Hennig
    3. Matthew D Golub
    4. Emily R Oby
    5. Patrick T Sadtler
    6. Aaron P Batista
    7. Steven M Chase
    8. Byron M Yu
    9. Peter E Latham
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study proposes a network implementation of the "re-aiming" learning strategy, which has been hypothesized to underlie brain-computer interface learning. Combining theoretical arguments, numerical simulations, and analysis of experimental data, the authors provide convincing evidence for their hypothesis. This paper will likely be of broad interest to the systems neuroscience community.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy

    This article has 7 authors:
    1. Maciej A Kerlin
    2. Ilham Aboulfath-Ladid
    3. Julia Roensch
    4. Chloé Jaubert
    5. Aude Battistella
    6. Kyra JE Borgman
    7. Antoine Coulon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study combines an innovative experimental approach with mathematical modeling to demonstrate that genes separated by strong topological boundaries can exhibit coordinated transcriptional bursting, providing new insights into how regulatory information is transmitted across the genome. The evidence is solid within the studied locus, but the interpretation and generality of the findings would be strengthened by additional validation using simulated data and broader application beyond a single genomic region. This work will be of interest to cell biologists and biophysicists working on transcription and chromatin.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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