eLife

Latest preprint reviews

1. mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

   This article has 9 authors:

   1. Philip Stavrides
   2. Chris N Goulbourne
   3. James Peddy
   4. Chunfeng Huo
   5. Mala Rao
   6. Vinod Khetarpal
   7. Deanna M Marchionini
   8. Ralph A Nixon
   9. Dun-Sheng Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is convincing. The original reviewers have found most of the issues previously raised have been addressed although further suggestions are given for consideration. These comments are listed below. The work will be of interest to neuroscientists working on HD.

   Reviewed by eLife

2. Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

   This article has 4 authors:

   1. Ryo Masumura
   2. Kyosuke Goda
   3. Mariko Sekiguchi
   4. Naofumi Uesaka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates the role of developmental oligodendrocytes in synchronising spontaneous activity in neuronal circuits and influencing cerebellar-dependent behaviour. The authors use advanced viral targeting techniques to deplete oligodendrocytes in a cell-specific manner, paired with in vivo calcium imaging of Purkinje cells, to establish a relationship between oligodendrocyte-mediated neuronal synchrony and complex brain function. The authors present compelling evidence of oligodendrocyte-regulated neuronal synchrony. Overall, this manuscript holds promise as an important contribution to neurodevelopment research.

   Reviewed by eLife

3. Detecting Regime Shifts: Neurocomputational Substrates for Over- and Underreactions to Change

   This article has 3 authors:

   1. Mu-Chen Wang
   2. George Wu
   3. Shih-Wei Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers valuable insights into how humans detect and adapt to regime shifts, highlighting dissociable contributions of the frontoparietal network and ventromedial prefrontal cortex to sensitivity to signal diagnosticity and transition probabilities. The combination of an innovative instructed-probability task, Bayesian behavioural modelling, and model-based fMRI analyses provides solid support for the main claims. The addition of new model-comparison figures in revision effectively addresses the previously noted potential confound between posterior switch probability and time in the neuroimaging results. At the behavioural level, while the computational model captures the pattern of "system neglect" well, qualitatively distinct mechanisms, such as hyper-prior attraction toward experiment-wise mean parameters, reporting biases, or probability-outlier underweighting, could produce similar behavioural signatures and cannot be fully disambiguated with the current design alone; however, converging evidence from the authors' prior work partially mitigates this concern.

   Reviewed by eLife

4. Neuronal detection triggers systemic digestive shutdown in response to adverse food sources in Caenorhabditis elegans

   This article has 8 authors:

   1. Yating Liu
   2. Guojing Tian
   3. Ziyi Wang
   4. Junkang Zheng
   5. Huimin Liu
   6. Sucheng Zhu
   7. Zhao Shan
   8. Bin Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how signals from the nervous system can influence the response to different food sources. To demonstrate the role of specific neuronal and intestinal regulators in sensing food quality and modulating digestion, the authors present evidence through a combination of genetic screening, RNA-seq analysis, and functional studies. These findings shed light on an adaptive strategy to integrate food perception with physiological responses, with a mix of solid and convincing evidence supporting the work.

   Reviewed by eLife

5. Changes in large-scale neural networks under stress are linked to affective reactivity to stress in real life

   This article has 7 authors:

   1. Rayyan Tutunji
   2. Martin Krentz
   3. Nikos Kogias
   4. Lycia de Voogd
   5. Florian Krause
   6. Eliana Vassena
   7. Erno J Hermans

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the effects of acute social stress on brain function, focusing on dynamic shifts in large-scale networks such as the salience and default mode networks. It highlights a robust association between stress-induced changes in salience network activation and stress reactivity in daily life, although evidence linking brain function changes following acute stress to real-life stress is incomplete. The findings are significant for stress biology research and could influence future studies on stress responses.

   Reviewed by eLife

6. Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody

   This article has 8 authors:

   1. Manuela C Aguirre-Botero
   2. Olga Pacios
   3. Susanna Celli
   4. Eduardo Aliprandini
   5. Anisha Gladston
   6. Jean-Michel Thiberge
   7. Pauline Formaglio
   8. Rogerio Amino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that a monoclonal antibody against the repetitive region of the circumsporozoite protein (CSP) of the Malaria-causing parasite P. berghei has neutralizing activity on parasite invasion and development. The authors present convincing in vivo data confirming previous in vitro work, that suggested the intracellular post -invasion effect for this antibody. The findings offer insights into the inhibitory action of this anti-CSP antibody, which could inform the development of more effective malaria vaccines and therapeutic antibodies."

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

7. Food intake enhances hippocampal sharp wave-ripples

   This article has 6 authors:

   1. Ekin Kaya
   2. Evan Wegienka
   3. Alexandra Akhtarzandi-Das
   4. Hanh Do
   5. Ada Eban-Rothschild
   6. Gideon Rothschild

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study assessed the effects of food intake on sharp wave-ripples in the hippocampus of mice during subsequent sleep. Convincing evidence supports the conclusion that sharp wave-ripples are enhanced by food consumption. This work will likely interest researchers studying multiple functions including memory, metabolism, and brain-body physiology.

   Reviewed by eLife

8. Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

   This article has 7 authors:

   1. Jessica Armand
   2. Sungsoo Kim
   3. Kibum Kim
   4. Eugene Son
   5. Minah Kim
   6. Kevin Kalinsky
   7. Hee Won Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in combination with CDK2 inhibitors, significantly suppresses the growth of drug-resistant cancer cells. The findings are supported by compelling evidence from both in vitro cell line experiments and in vivo mouse models, highlighting the therapeutic potential of maintaining CDK4/6 inhibitors beyond disease progression. Additionally, the identification of cyclin E overexpression as a key driver of resistance offers a target that will be of value for future therapeutic strategies, potentially improving outcomes for patients with advanced breast cancer.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/gf7mr

10. The title and authors for this article are not available from our external data provider yet:
    10.31219/osf.io/vbtzq