eLife

Latest preprint reviews

1. Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

   This article has 12 authors:

   1. Darren Wethington
   2. Saeed Ahmad
   3. Marc Potempa
   4. Giuseppe Giuliani
   5. Oscar A Aguilar
   6. Maheshwor Poudel
   7. Simon Grassmann
   8. William Stewart
   9. Nicholas M Adams
   10. Joseph C Sun
   11. Lewis L Lanier
   12. Jayajit Das

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study combines mathematical models and experimental data to analyse the emergence of heterogeneity within clonal NK cell responses during antigen-specific cell expansion. It comprises different experimental data and extensively explores various mathematical models, to study NK cell turnover during acute immune responses and homeostatic turnover within murine cytomegalovirus infection (MCMV). The solid study presents valuable findings and provides insights on heterogeneous NK cell development

   Reviewed by eLife

2. Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis

   This article has 4 authors:

   1. Nicholas A Dillon
   2. Elise A Lamont
   3. Muzafar A Rather
   4. Anthony D Baughn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important advances in understanding how pyrazinamide, a first-line antibiotic for tuberculosis treatment, is effective in vivo. The experimental design and data provide solid evidence that the production of reactive oxygen species by host cells contributes to how pyrazinamide is more potent in the host than in culture conditions; however, additional experiments and controls would strengthen these conclusions. This work is of interest to the antibiotic drug development field.

   Reviewed by eLife

3. Clonal analysis of murine HSC self-renewal and differentiation in native hematopoiesis

   This article has 4 authors:

   1. Chenyu You
   2. Zhen Zhang
   3. Li Lin
   4. Jianlong Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     You et al. present an important study that applied a high-resolution transposon-based barcoding system to show the clonal contribution of hematopoietic stem and progenitor cells during aging, after 5-FU treatment, and upon transplantation. The results are convincing and show that there are different categories of multipotent progenitors that are either active or indolent, and that long-term fates are dominated by clones that either favor differentiation or self-renewal. This study will be of broad interest to stem-cell biologists and could reach an even wider audience with a clearer and more concise presentation and discussion of the results.

   Reviewed by eLife

4. Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

   This article has 9 authors:

   1. Ellen Späth
   2. Svenja C Schüler
   3. Ivonne Heinze
   4. Therese Dau
   5. Alberto Minetti
   6. Maleen Hofmann
   7. Katja Hönzke
   8. Julia von Maltzahn
   9. Alessandro Ori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the regulation of myogenic differentiation by identifying Leiomodin 1 as a modulator of proteome dynamics during myogenic differentiation. The combination of quantitative proteomics with functional perturbation experiments offers solid evidence supporting the idea that SIRT1 influences perturbations of myogenic differentiation upon LMOD1 inactivation. These findings advance our understanding of muscle differentiation and will be of interest to researchers studying muscle development and related pathologies

   Reviewed by eLife

5. Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

   This article has 10 authors:

   1. Álvaro Escobar Doncel
   2. Constantinos Patinios
   3. Alexandre Campos
   4. Maria Beatriz Walter Costa
   5. Maria V Turkina
   6. Maria Murace
   7. Raymond HJ Staals
   8. Silvia Vignolini
   9. Bas E Dutilh
   10. Colin J Ingham

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents important findings on how structural color can be manipulated through a specific single-gene mutation in a motile bacterium. Compelling data provide a promising model to identify genes and molecular mechanisms supporting this widespread optical phenomenon. This work will be of interest to biophysicists and microbiologists working on structural colors and Flavobacterium.

   Reviewed by eLife

6. Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

   This article has 6 authors:

   1. Nobuyuki Nosaka
   2. Vanessa Borges
   3. Daisy Martinon
   4. Timothy R Crother
   5. Moshe Arditi
   6. Kenichi Shimada

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a comprehensive exploration of the role of hypothermia of mitigating IL1beta induction and NETosis in the context of lung injury induced by mechanical ventilation. The data are convincing, and the study is important for the field.

   Reviewed by eLife

7. Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

   This article has 2 authors:

   1. Richa Sirmaur
   2. Rishikesh Narayanan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable theoretical exploration on the electrophysiological mechanisms of ionic currents via gap junctions in hippocampal CA1 pyramidal-cell models, and their potential contribution to local field potentials (LFPs) that is different from the contribution of chemical synapses. The biophysical argument regarding electric dipoles appears solid, but the evidence would be stronger if their predictions are tested against experiments. A shortage of model validation and strictly comparable parameters used in the comparisons between chemical vs. junctional inputs makes the modeling approach incomplete; once strengthened, the finding can be of broad interest to electrophysiologists, who often make recordings from regions of neurons interconnected with gap junctions.

   Reviewed by eLife

8. Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

   This article has 6 authors:

   1. Jing Xue
   2. Weizhong Zeng
   3. Scott John
   4. Nicole Attiq
   5. Michela Ottolia
   6. Youxing Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Cardiac Ca2+/Na+ exchange is mediated by the NCX1 antiporter, whose activity is tightly regulated. This important manuscript describes the structural basis of activation by the lipid DiC8-PIP2 and inhibition by binding of a small molecule to NCX1. These results provide convincing insights into NCX1 regulation and the structural basis of cellular Ca2+ signaling.

   Reviewed by eLife

9. Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

   This article has 12 authors:

   1. Qiwang Xiang
   2. Camille Wouters
   3. Peixi Chang
   4. Yu-Ning Lu
   5. Mingming Liu
   6. Haocheng Wang
   7. Haley Heine
   8. Sunning Qian
   9. Junqin Yang
   10. Andrew Pekosz
   11. Yanjin Zhang
   12. Jiou Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study demonstrates that the E3 ligase ITCH regulates several steps of the SARS-CoV-2 replication cycle by enhancing ubiquitination of viral envelope and membrane proteins. The phenotypic data are based on solid evidence showing a role for ITCH in distinct phases of viral replication and host processes. The findings lay the ground work for future studies to decipher detailed molecular mechanisms that explain how ITCH regulates SARS-CoV-2.

   Reviewed by eLife

10. Frictional instabilities as an alternative to friction coefficient in fine touch perception

    This article has 6 authors:

    1. Maryanne Derkaloustian
    2. Pushpita Bhattacharyya
    3. Truc T Ngo
    4. Josh GA Cashaback
    5. Jared Medina
    6. Charles B Dhong

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful study integrates experimental methods from materials science with psychophysical methods to investigate how frictional stabilities influence tactile surface discrimination. The authors argue that force fluctuations arising from transitions between frictional sliding conditions facilitate the discrimination of surfaces with similar friction coefficients. However, the reliance on friction data from an artificial finger, combined with correlational analyses that fall short of establishing a mechanistic link to perception, renders the findings incomplete.

    Reviewed by eLife