Latest preprint reviews

  1. Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

    This article has 11 authors:
    1. Wei Dong
    2. Guihu Wang
    3. Senyang Li
    4. Yichao Chai
    5. Qian Wang
    6. Yucheng Li
    7. Qiaoman Fei
    8. Yujin Zong
    9. Jing Geng
    10. Pengfei Liu
    11. Zongfang Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents an innovative noninvasive immunotherapeutic strategy for hepatocellular carcinoma by combining ultrasound stimulation with calcium-loaded nanodroplets to activate splenic immune responses. The authors provide solid preclinical data, including single-cell transcriptomic analyses and evidence of tumor growth suppression, supported by a creative and well-executed methodology. Further validation of the calcium signaling mechanisms and assessment of long-term safety will strengthen the translational potential of this approach. The work will be of broad interest to researchers in oncology, immunotherapy, and biomedical engineering.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments

    This article has 10 authors:
    1. Terence Li
    2. Marcus Alvarez
    3. Cuining Liu
    4. Kevin Abuhanna
    5. Yu Sun
    6. Jason Ernst
    7. Kathrin Plath
    8. Brunilda Balliu
    9. Chongyuan Luo
    10. Noah Zaitlen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study introduces ambisim, a rigorously validated and well-documented simulation framework that enables the generation of synthetic, genotype-aware single-cell RNA and ATAC sequencing datasets under realistic conditions. The authors provide solid evidence of its utility by benchmarking multiple demultiplexing methods and proposing a new variant consistency metric. While the tool is valuable for guiding method selection, the interpretation of the new metric requires further clarification.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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