eLife

Latest preprint reviews

1. Genetic compensation in podocalyxin-like mutants during zebrafish liver development

   This article has 8 authors:

   1. Alexis N Ross
   2. Natalie M Miscik
   3. Sharanya Maanasi Kalasekar
   4. James D Harris
   5. Mimi Tran
   6. Aavrati Saxena
   7. Steven Andrew Baker
   8. Kimberley Jane Evason

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript by Ross, Miscik, and others describes an intriguing series of observations made when investigating the requirement for podxl during hepatic development in zebrafish. Understanding how genetic compensation pathways are involved in gene function is an important question. However, there is incomplete evidence provided in the manuscript at this point to conclude that discrepancies between observed phenotypes are due to genetic compensation.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.05.15.654314

3. We couldn't get details of this article at this time:
   10.1101/2025.04.08.647738

4. Molecular landscape of the mouse adrenal gland and adjacent adipose tissue by spatial transcriptomics

   This article has 9 authors:

   1. Malgorzata Blatkiewicz
   2. Szymon Hryhorowicz
   3. Marta Szyszka
   4. Joanna Suszynska-Zajczyk
   5. Andrzej Plawski
   6. Adam Plewinski
   7. Andrea Porzionato
   8. Ludwik K. Malendowicz
   9. Marcin Rucinski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study provides a spatial transcriptomic analysis of the mouse adrenal gland that could have implications for future research and applications. The authors present solid results that allow the dissection of the cell signalling pathways and cellular composition of different zones of the adrenal glands in the mouse model; they propose new zone-specific gene markers and specific intra- and inter-zonal signaling pathways based on receptor-ligand expression patterns. Their web tool is user-friendly and will be helpful for adrenal scientists; however, the validation of crucial results of the large dataset is necessary. There are also several contradictory results/interpretations, and the opportunity to dissect the sexually dimorphic gene expression pattern and mouse-human interspecies differences is a missed opportunity.

   Reviewed by eLife

5. SIRT2 protects against Japanese encephalitis virus infection in mice

   This article has 9 authors:

   1. Perumal Arumugam Desingu
   2. Lavanya Dindi
   3. Krishnega Murugasamy
   4. Ankit Kumar Tamta
   5. Venketsubbu Ramasubbu
   6. Sukanya Raghu
   7. Amarjeet Shrama
   8. Raju S Rajmani
   9. Nagalingam R Sundaresan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study explores the role of SIRT2 in regulating Japanese encephalitis virus replication and disease progression in rodent models. The findings presented are novel as sirtuins are known for their roles in aging, metabolism, and cell survival, but have not been studied in the context of viral infections until recently. The evidence supporting the claims is solid, although additional experiments to further characterize the clinical outcomes and directly test the link between acetylated NF-kB and SIRT2 expression would have strengthened the study. The work will be of interest to biologists studying viruses, sirtuins, and inflammation.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2025.04.15.25325914

7. Species biology and demographic history determine species vulnerability to climate change in tropical island endemic birds

   This article has 6 authors:

   1. Ratnesh Karjee
   2. Vikram Iyer
   3. Durbadal Chatterjee
   4. Rajasri Ray
   5. Kritika M Garg
   6. Balaji Chattopadhyay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Tropical single-island endemic bird populations are particularly vulnerable to climate change. This study investigates genetic evidence of how such species dealt with climate change in the past as a possible predictor of how they will respond in the future, which could provide an important example for the fields of conservation genetics and island biogeography. The authors' integration of genomics and habitat modeling is commendable, but we find that the support for their conclusions is currently inadequate: some model parameter choices do not seem to reflect the biology of the studied species or to be well founded, which can cause misalignment of modeled dynamics with glaciation windows crucial for interpreting the study's results against its claims.

   Reviewed by eLife

8. Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   This article has 8 authors:

   1. Sarah M Chang
   2. Muhammad Bin Munim
   3. Sonia E Trojan
   4. Huel Cox
   5. Anna Shevzov-Zebrun
   6. Keene L Abbott
   7. Renee Chang
   8. Matthew G Vander Heiden

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide convincing evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of broad interest to researchers working in cancer and cell metabolism.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2025.03.31.646438

10. We couldn't get details of this article at this time:
    10.1101/2025.03.25.645375