Latest preprint reviews

  1. PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

    This article has 17 authors:
    1. Shiyi Wang
    2. Ryan Baumert
    3. Gabrielle Séjourné
    4. Dhanesh Sivadasan Bindu
    5. Kylie Dimond
    6. Kristina Sakers
    7. Leslie Vazquez
    8. Jessica L Moore
    9. Christabel Xin Tan
    10. Tetsuya Takano
    11. Maria Pia Rodriguez
    12. Nick Brose
    13. Luke Bradley
    14. Reed Lessing
    15. Scott H Soderling
    16. Albert R La Spada
    17. Cagla Eroglu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The findings are convincing, as they rely on a comprehensive set of in vivo and in vitro genetic, biochemical, proteomic, and electrophysiological approaches. They are important because of their translational value, being validated in both mouse models and post-mortem human samples.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

    This article has 6 authors:
    1. Hai Qiu
    2. Xia Yue
    3. Yuebing Huang
    4. Ziling Meng
    5. Jiahong Wang
    6. Dongfang Qiao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns about data interpretation, and the current evidence is incomplete, requiring further experimental validation.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Unreliable homeostatic action potential broadening in cultured dissociated neurons

    This article has 16 authors:
    1. Andreas Ritzau-Jost
    2. Salil Rajayer
    3. Jana Nerlich
    4. Filip Maciag
    5. Alexandra John
    6. Michael Russier
    7. Victoria Gonzalez Sabater
    8. Luke J Steiger
    9. Jacques-Olivier Coq
    10. Jens Eilers
    11. Maren Engelhardt
    12. Juan Burrone
    13. Dominique Debanne
    14. Martin Heine
    15. Stephen M Smith
    16. Stefan Hallermann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple brain regions and laboratories, the authors demonstrate that AP half-width remains largely stable, challenging previous assumptions in the field. These important findings help resolve longstanding inconsistencies in the literature and significantly advance our understanding of neuronal network homeostasis. The authors have clarified methodological differences with prior work and expanded the discussion of potential mechanisms, strengthening the interpretation of the findings without altering the central conclusions.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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