eLife

Latest preprint reviews

1. Integration of head and body orientations in the macaque superior temporal sulcus is stronger for upright bodies

   This article has 2 authors:

   1. Yordanka Zafirova
   2. Rufin Vogels

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the neuronal mechanisms underlying visual perception of integrated face and body cues. The innovative paradigm, which employs monkey avatars in combination with electrophysiological recordings from fMRI-defined brain areas, provides compelling evidence on face and body integration. These results should be of wide interest to system and cognitive neuroscientists, psychologists, and behavioural biologists working on visual and social cognition.

   Reviewed by eLife

2. Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

   This article has 3 authors:

   1. Guangzhao Cheng
   2. Aki Vehtari
   3. Lu Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents SegPore, a valuable new method for processing direct RNA nanopore sequencing data, which improves the segmentation of raw signals into individual bases and boosts the accuracy of modified base detection. The evidence presented to benchmark SegPore is solid, and the authors provide a fully documented implementation of the method. SegPore will be of particular interest to researchers studying RNA modifications.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.05304v3

4. The role of GABA in semantic memory and its neuroplasticity

   This article has 3 authors:

   1. JeYoung Jung
   2. Steve Williams
   3. Matthew A Lambon Ralph

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Jung et al. present valuable work on the relationship between gamma-aminobutyric acid (GABA) levels within the anterior temporal lobes (ATL) to semantic memory while accounting for inter-individual differences. They provide solid evidence suggesting that inhibitory continuous theta burst transcranial magnetic stimulation (cTBS TMS) increased GABA concentration and decreased the blood-oxygen dependent signal (BOLD) during a semantic task. The results will be of interest to researchers studying the neurobiology of semantic cognition.

   Reviewed by eLife

5. The resource elasticity of control

   This article has 3 authors:

   1. Levi Solomyak
   2. Aviv Emanuel
   3. Eran Eldar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study makes the valuable claim that people track, specifically, the elasticity of control (that is, the degree to which outcome depends on how many resources - such as money - are invested), and that control elasticity is impaired in certain types of psychopathologies. A novel task is introduced that provides solid evidence that this learning process occurs and that human behavior is sensitive to changes in the elasticity of control. Evidence that elasticity inference is distinct from more general learning mechanisms and is related to psychopathology remains incomplete.

   Reviewed by eLife

6. Association between continuous glucose monitoring-derived metrics and coronary plaque vulnerability: A retrospective exploratory analysis

   This article has 10 authors:

   1. Hikaru Sugimoto
   2. Ken-ichi Hironaka
   3. Tomoko Yamada
   4. Natsu Otowa-Suematsu
   5. Yushi Hirota
   6. Hiromasa Otake
   7. Ken-Ichi Hirata
   8. Kazuhiko Sakaguchi
   9. Wataru Ogawa
   10. Shinya Kuroda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable retrospective analysis identified three independent components of glucose dynamics - "value," "variability," and "autocorrelation" - which may be used in predicting coronary plaque vulnerability. The study is solid and of interest to a wide range of investigators in the medical field who are interested in the role of glycemia on cardiometabolic health. The manuscript has been substantially strengthened by clarifying methods, improving transparency, and validating key findings, resulting in a coherent and persuasive case for autocorrelation as a meaningful third dimension of glucose dynamics despite remaining design-related limitations.

   Reviewed by eLife

7. Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

   This article has 20 authors:

   1. Keva Li
   2. Nicholas Tolman
   3. Ayellet V Segrè
   4. Kelsey V Stuart
   5. Oana A Zeleznik
   6. Neeru A Vallabh
   7. Kuang Hu
   8. Nazlee Zebardast
   9. Akiko Hanyuda
   10. Yoshihiko Raita
   11. Christa Montgomery
   12. Chi Zhang
   13. Pirro G Hysi
   14. Ron Do
   15. Anthony P Khawaja
   16. Janey L Wiggs
   17. Jae H Kang
   18. Simon WM John
   19. Louis R Pasquale
   20. UK Biobank Eye and Vision Consortium

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the importance of the plasma metabolome in glaucoma risk prediction. The evidence supporting the claims of the authors is solid and the work offers insights for the design of protective therapeutic strategies for glaucoma. The authors have addressed the concerns of the reviewers and reported on the limitations of the study.

   Reviewed by eLife

8. Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

   This article has 20 authors:

   1. Kerstin Seidel
   2. Robert Piskol
   3. Thi Thu Thao Nguyen
   4. Amy Shelton
   5. Charisa Cottonham
   6. Cecile C de la Cruz
   7. Joseph Castillo
   8. Jesse Garcia
   9. Udi Segal
   10. Mark Merchant
   11. Yeqing Angela Yang
   12. Jasmine Chen
   13. Musa Ahmed
   14. Alexis Scherl
   15. Rajesh Vij
   16. Lluc Mosteiro
   17. Yan Wu
   18. Zora Modrusan
   19. Ciara Metcalfe
   20. Chris Siebel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, Seidel et al. identify and characterize a novel subset of hepatocellular carcinoma patient-derived xenograft models defined by active Jagged 1-Notch2 signaling and a distinctive progenitor-like gene expression profile. Within the limitations of the PDX system they used, their methods are state-of-the-art, their data are strong and believable, and their conclusions are convincing. However, the ability to identify HCC patients that might respond is limited, and the mechanistic assessment downstream of JAG1/NOTCH2 is relatively descriptive. Some additional clarifications and experiments would strengthen the paper.

   Reviewed by eLife

9. Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

   This article has 6 authors:

   1. Christian D Mutti
   2. Lindsey Van Haute
   3. Lucia Luengo-Gutierrez
   4. Keira Turner
   5. Pedro Silva-Pinheiro
   6. Michal Minczuk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors have demonstrated the use of adenine base editors delivered via adeno-associated viruses to introduce edits in the mitochondrial genome. The manuscript describes the methodology well, and the conclusions are convincingly supported by the results. The valuable results highlight the potential of these base editors to model mtDNA variations in somatic tissues in animal models.

   Reviewed by eLife

10. Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

    This article has 10 authors:

    1. Upneet K Sokhi
    2. Ruoxi Yuan
    3. Bikash Mishra
    4. Yurii Chinenov
    5. Anvita Singaraju
    6. Karmela K Chan
    7. Anne Bass
    8. Richard D Bell
    9. Laura Donlin
    10. Lionel B Ivashkiv

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with compelling evidence the effects of PGE2 on TNF signaling. This work will be of broad interest to immunologists and cell biologists.

    Reviewed by eLife