eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2025.04.06.647459

2. We couldn't get details of this article at this time:
   10.1101/2025.05.12.653469

3. We couldn't get details of this article at this time:
   10.1101/2025.04.20.649706

4. Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

   This article has 7 authors:

   1. Zeming Qiu
   2. Wei Wang
   3. Yingying Nie
   4. Junxiang Lin
   5. Beimeng Zhang
   6. Haonan Xing
   7. Sanduo Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Qiu et al. present multiple dimeric structures of GPR3, which reveal the binding mode of the inverse agonist AF64394. The findings provide important insights into the regulation of GPCR3 and potentially other related orphan GPCRs. The authors present convincing evidence of their claims through thoughtful analysis of their cryo-EM structures, mutagenesis, and cell-based assays. This work will be of interest to GPCR investigators, especially those studying the signaling of orphan receptors.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2025.03.24.645038

6. Synaptic Encoding of Time in Working Memory

   This article has 2 authors:

   1. Gianluigi Mongillo
   2. Misha Tsodyks

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper develops a fundamental theory that explains how the brain can hold in working memory not only the identity but also the order of presented stimuli. Previous theories did not explain the ability of people to immediately recall the correct order of the stimulus presentation. The authors present compelling evidence that this can be achieved through synaptic augmentation, an experimentally observed phenomenon with a time scale of tens of seconds.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.05.26.656082

8. Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

   This article has 2 authors:

   1. Aditya Asopa
   2. Upinder Singh Bhalla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study examines excitation/inhibition (E/I) balance in the CA3-CA1 circuit of the hippocampus. Experimental and computational modeling results are presented. The computational modeling results were viewed as a novel advance supported by solid evidence, but incomplete evidence was provided to support the paper's main experimental claims due to deficiencies in the experimental methodology and concerns about the neurobiological relevance of the experimental observations.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2025.05.04.652118

10. We couldn't get details of this article at this time:
    10.1101/2025.04.23.650346