eLife

Latest preprint reviews

1. Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer

   This article has 14 authors:

   1. Jianying Xu
   2. Wenjie Shi
   3. Yi Zhu
   4. Chao Zhang
   5. Julia Nagelschmitz
   6. Maximilian Doelling
   7. Sara Al-Madhi
   8. Ujjwal Mukund Mahajan
   9. Maciej Pech
   10. Georg Rose
   11. Roland Siegfried Croner
   12. Guoliang Zheng
   13. Christoph Kahlert
   14. Ulf Dietrich Kahlert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors attempt to identify which patients with benign lesions will progress to cancer using a liquid biomarker. Although the study is valuable, the evidence provided for the liquid biopsy EV miRNA signature developed based on radiomics features remains incomplete. There remain key details missing and validation experiments that would better support the conclusions of the study.

   Reviewed by eLife

2. Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation

   This article has 4 authors:

   1. Pei-Tzu Chen
   2. Jia-Yin Yeh
   3. Jui-Hsia Weng
   4. Kuen-Phon Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors employed state-of-the-art biochemistry, cryo-EM, and HDX mass spec approaches to study the formation of the binary Uba7-UBE2L6 and ternary UBA7-UBE2L6-ISG15 complexes. The results established mechanisms by which UBA7 and UBE2L6 form disulfide bonds, disrupting the ISG15 transfer cascade. While the biochemical and structural experiments are largely convincing, the mechanism under in vivo conditions remains unclear, due to the limited use of a single E2 enzyme. The authors need to repeat their experiments with a representative panel of human E2 enzymes.

   Reviewed by eLife

3. Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

   This article has 3 authors:

   1. Kai S Shimagaki
   2. Rebecca M Lynch
   3. John P Barton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important quantitative study of HIV-1 evolution in humans and rhesus macaques, selection coefficients are inferred at scale over the HIV genome. Selection coefficients are similar in humans and macaques, providing compelling evidence that these coefficients are representative of the fitness landscapes of these viruses within hosts. This work will be of interest to the community working on quantitative evolution and fitness landscape inference, and the finding that rapid fitness gains in the HIV population predict bNAb emergence has significant implications for HIV vaccine design.

   Reviewed by eLife

4. Effects of parental care on skin microbial community composition in poison frogs

   This article has 9 authors:

   1. Marie-Therese Fischer
   2. Katherine S Xue
   3. Elizabeth K Costello
   4. Mai Dvorak
   5. Gaelle Raboisson
   6. Anna Robaczewska
   7. Stephanie N Caty
   8. David A Relman
   9. Lauren A O'Connell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important perspective on the influence of parental care in the establishment of the amphibian microbiome. Through a combination of cross-fostering experimental work, comparative analysis, and developmental time series, the authors provide compelling evidence that vertical transmission through care is possible, and solid but somewhat preliminary evidence that it plays a significant role in shaping frog skin microbiomes in nature or across time. This work will be of interest to researchers studying the evolution of parental care and microbiomes in vertebrates.

   Reviewed by eLife

5. In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

   This article has 12 authors:

   1. Daniel T Hass
   2. Elizabeth Giering
   3. John YS Han
   4. Celia M Bisbach
   5. Kriti Pandey
   6. Brian M Robbings
   7. Thomas O Mundinger
   8. Nicholas D Nolan
   9. Stephen H Tsang
   10. Neal S Peachey
   11. Nancy J Philp
   12. James B Hurley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This research is valuable as it investigates metabolic shuttling between photoreceptors and retinal pigment epithelium (RPE) using in vivo infusion techniques and mouse models. The authors find that the retina significantly relies on circulating glucose, with photoreceptors being the primary consumers of glucose, which is convincing. However, the study has incomplete evidence to support the claims that photoreceptors can use lactate as a fuel source, that lactate exported from photoreceptors is utilized by the RPE, and that lactate contributes to the TCA cycle in the RPE. These claims need substantial revision to include potential alternative explanations or perform key experiments.

   Reviewed by eLife

6. Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

   This article has 9 authors:

   1. Qian Xiu
   2. Xiaoru Yin
   3. Yuanyuan Chen
   4. Ziyang Zhang
   5. Yushuai Mao
   6. Tianshi Wang
   7. Jie Zhang
   8. Mingguo Zhou
   9. Yabing Duan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, the authors show the physiological response and molecular pathway mediating the effect of quinofumelin, a developed fungicide with an unknown mechanism. The authors present convincing data suggesting the involvement of the uridine/uracil biosynthesis pathway, by combining in vivo microbiology characterization as well as in vitro biochemical binding results.

   Reviewed by eLife

7. Layilin regulates Treg motility and suppressive capacity in skin

   This article has 18 authors:

   1. Victoire Gouirand
   2. Sean Clancy
   3. Courtney Macon
   4. Jose Valle
   5. Mariela Pauli
   6. Hong-An Truong
   7. Jarish Cohen
   8. Maxime Kinet
   9. Margaret M Lowe
   10. Samuel J Lord
   11. Kristen Skruber
   12. Hobart Harris
   13. Esther Kim
   14. Isaac Neuhaus
   15. Karin Reif
   16. Ali A Zarrin
   17. R Dyche Mullins
   18. Michael D Rosenblum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

   Reviewed by eLife, Arcadia Science

8. CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy

   This article has 11 authors:

   1. Shuangshuo Jia
   2. Zhehan Hu
   3. Zihan Li
   4. Weiming Zhang
   5. Liang Chen
   6. Changping Niu
   7. Ziqi Zhao
   8. Yuhan Sun
   9. Gang Yao
   10. Yang Wang
   11. Yue Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript by Jia et al. investigates the role of cartilage intermediate layer protein (CILP) and moderate exercise in maintaining hyaline cartilage integrity following anterior cruciate ligament transection (ACLt) in rats. Solid data support the downregulation of CILP in human OA cartilage and its potential role in regulating Keap1/Nrf2 interaction and chondrocyte ferroptosis. However, the data supporting a role for CILP in exercise-mediated inhibition of hyaline cartilage fibrosis in early OA are incomplete.

   Reviewed by eLife

9. Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms

   This article has 14 authors:

   1. Jean-Mathieu Desveaux
   2. Eric Faudry
   3. Carlos Contreras-Martel
   4. François Cretin
   5. Leonardo Sebastian Dergan-Dylon
   6. Axelle Amen
   7. Isabelle Bally
   8. Victor Tardivy-Casemajor
   9. Fabien Chenavier
   10. Delphine Fouquenet
   11. Yvan Caspar
   12. Ina Attree
   13. Andrea Dessen
   14. Pascal Poignard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful work identifies new monoclonal antibodies produced by cystic fibrosis patients against Pseudomonas aeruginosa type three secretion system. The evidence supporting authors' claim is solid. Nonetheless, the manuscript may benefit from a more in depth description of what the authors learned from their structure-based analyses of antibodies targeting PcrV.

   Reviewed by eLife

10. Cross-modal interaction of Alpha Activity does not reflect inhibition of early sensory processing: A frequency tagging study using EEG and MEG

    This article has 8 authors:

    1. Marion Brickwedde
    2. Rupali Limachya
    3. Roksana Markiewicz
    4. Emma Sutton
    5. Christopher Postzich
    6. Kimron Shapiro
    7. Ole Jensen
    8. Ali Mazaheri

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable manuscript provides solid evidence regarding the role of alpha oscillations in sensory gain control. The authors use an attention-cuing task in an initial EEG study followed by a separate MEG replication study to demonstrate that whilst (occipital) alpha oscillations are increased when anticipating an auditory target, so is visual responsiveness as assessed with frequency tagging. The findings offer a re-interpretation of the inhibitory role of the alpha rhythm, supporting that alpha oscillations contribute to interareal communication.

    Reviewed by eLife