eLife

Latest preprint reviews

1. Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

   This article has 19 authors:

   1. Antara Sengupta
   2. Soujanya Vinayagamurthy
   3. Dristhi Soni
   4. Rajlekha Deb
   5. Ananda Kishore Mukherjee
   6. Subhajit Dutta
   7. Jushta Jaiswal
   8. Mukta Yadav
   9. Shalu Sharma
   10. Sulochana Bagri
   11. Shuvra Shekhar Roy
   12. Priya Poonia
   13. Ankita Singh
   14. Divya Khanna
   15. Amit Kumar Kumar Bhatt
   16. Akshay Sharma
   17. Suman Saurav
   18. Rajender K Motiani
   19. Shantanu Chowdhury

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

   Reviewed by eLife

2. Olfactory bulb tracks breathing rhythms and place in freely behaving mice

   This article has 11 authors:

   1. Scott C Sterrett
   2. Teresa M Findley
   3. Sidney E Rafilson
   4. Morgan A Brown
   5. Aldis P Weible
   6. Rebecca Marsden
   7. Takisha Tarvin
   8. Michael Wehr
   9. James M Murray
   10. Adrienne L Fairhall
   11. Matthew C Smear

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study linking olfactory bulb activity not only to sniffing parameters but also to movement and place. The evidence for odor sampling is mostly solid, but the analysis supporting the potentially exciting result on the encoding of place is currently incomplete.

   Reviewed by eLife

3. Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

   This article has 27 authors:

   1. Inbal Avraham-Davidi
   2. Simon Mages
   3. Johanna Klughammer
   4. Noa Moriel
   5. Shinya Imada
   6. Matan Hofree
   7. Evan Murray
   8. Jonathan Chen
   9. Karin Pelka
   10. Arnav Mehta
   11. Genevieve M Boland
   12. Toni Delorey
   13. Leah Caplan
   14. Danielle Dionne
   15. Robert Strasser
   16. Jana Lalakova
   17. Anezka Niesnerova
   18. Hao Xu
   19. Morgane Rouault
   20. Itay Tirosh
   21. Hacohen Nir
   22. Fei Chen
   23. Omer Yilmaz
   24. Jatin Roper
   25. Orit Rozenblatt-Rosen
   26. Mor Nitzan
   27. Aviv Regev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents a valuable resource combining scRNA-seq and spatial transcriptomics studies to map mouse pre-clinical models of colorectal cancer, identifying distinct cellular programs and microenvironments that could enhance patient stratification and therapeutic approaches in colorectal cancer. While the evidence provided in the manuscript are not fully validated, these solid data were collected and analyzed using a validated methodology that will be of interest to the community in future studies.

   Reviewed by eLife

4. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

   This article has 11 authors:

   1. Alina Xiaoyu Yang
   2. Lisa Ramos-Rodriguez
   3. Parand Sorkhdini
   4. Dongqin Yang
   5. Carmelissa Norbrun
   6. Sonoor Majid
   7. Sanghyun Lee
   8. Yong Zhang
   9. Michael Holtzman
   10. David F Boyd
   11. Yang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

   Reviewed by eLife

5. Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

   This article has 9 authors:

   1. Rémy Torro
   2. Beatriz Díaz-Bello
   3. Dalia El Arawi
   4. Ksenija Dervanova
   5. Lorna Ammer
   6. Florian Dupuy
   7. Patrick Chames
   8. Kheya Sengupta
   9. Laurent Limozin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     CellDetective is a useful software package for segmentation, tracking, and analysis of time‐lapse microscopy datasets, specifically designed to be accessible to researchers without coding expertise. The authors provide solid evidence of its capabilities through comprehensive validations and well‐executed comparisons across immunological assays. However, the current implementation is limited to 2D widefield imaging and presents technical challenges - including occasional crashes, restricted flexibility in defining multiple cell populations, and some interface issues that hinder the full user experience. Overall, this work will be of significant interest to the bioimaging community, especially those in immunology and cell biology, and promises to evolve into a more robust tool with further development.

   Reviewed by eLife

6. Modularity of the segmentation clock and morphogenesis

   This article has 3 authors:

   1. James E Hammond
   2. Ruth E Baker
   3. Berta Verd

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

7. Extracellular adenosine deamination primes tip organizer development in Dictyostelium

   This article has 2 authors:

   1. Pavani Hathi
   2. Baskar Ramamurthy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     During the development of the unicellular eukaryote Dictyostelium discoideum, cells aggregate into mounds, forming protrusions or tips, which then become the front of migrating slugs and the top of fruiting bodies. This valuable study identifies adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation and convincingly shows that ADGF catalyses the conversion of adenosine to ammonia, allowing ammonia to initiate tip formation, and then elucidates pathways upstream and downstream of ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also similarly regulate development.

   Reviewed by eLife, Arcadia Science

8. Comparative fMRI reveals differences in the functional organization of the visual cortex for animacy perception in dogs and humans

   This article has 6 authors:

   1. Eszter Borbála Farkas
   2. Raúl Hernández-Pérez
   3. Laura Veronica Cuaya
   4. Eduardo Rojas-Hortelano
   5. Márta Gácsi
   6. Attila Andics

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a comparative investigation of category selectivity in dogs and humans. The study compares brain representations of animate and inanimate objects, replicating and extending previous reports in this nascent field of dog FMRI. The methods and results seem to lack sufficient detail, appropriate controls, or statistical evidence, so at this stage of the review process, the strength of evidence is deemed incomplete.

   Reviewed by eLife

9. On CA1 ripple oscillations in rats and the reassessment of asynchronicity evidence

   This article has 2 authors:

   1. Robson Scheffer-Teixeira
   2. Adriano BL Tort

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. Using carefully designed statistical methods, it presents compelling evidence that synchrony is significantly higher within a hemisphere than across. This study will be of interest to neuroscientists studying the hippocampus and memory.

   Reviewed by eLife

10. Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    This article has 9 authors:

    1. Yusuke Sakai
    2. Saumik Sen
    3. Tomohiro Sugihara
    4. Yukiya Kakeyama
    5. Makoto Iwasaki
    6. Gebhard FX Schertler
    7. Xavier Deupi
    8. Mitsumasa Koyanagi
    9. Akihisa Terakita

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors provide compelling evidence that a chloride ion stabilizes the protonated Schiff base chromophore linkage in the animal rhodopsin Antho2a. This important finding is novel and of major interest to a broad audience, including optogenetics researchers, protein engineers, spectroscopists, and environmental biologists. The study combines state-of-the-art research methods, such as spectroscopic and mutational analyses, which are complemented by QM/MM calculations, and was further improved based on the comments from the reviewers.

    Reviewed by eLife