eLife

Latest preprint reviews

1. Navigating contradictions in enteric chemotactic stimuli

   This article has 5 authors:

   1. Kailie Franco
   2. Zealon Gentry-Lear
   3. Michael Shavlik
   4. Michael J Harms
   5. Arden Baylink

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, Franco and colleagues present compelling evidence that fecal extracts containing high concentrations of indole, a known repellent, enhance rather than protect against invasion of colonic tissue by Salmonella. The authors describe important findings that lead to the conclusion that the competing effects of attractants present in fecal matter, including L-serine, also sensed by the Tsr chemoreceptor that senses indole, override the repulsive effect of indole.

   Reviewed by eLife

2. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

   This article has 4 authors:

   1. Jessica Mella
   2. Regan F Volk
   3. Balyn W Zaro
   4. Abigail Buchwalter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the delivery of a nuclear envelop protein to lysosomes and the impact of C-terminal tagging on its traffic. The authors provide solid evidence for the potential artifacts introduced by large terminal tags, particularly in the context of membrane protein localization and stability.

   Reviewed by eLife

3. Agent-based modeling reveals how bats navigate dense group emergences

   This article has 2 authors:

   1. Omer Mazar
   2. Yossi Yovel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important model-based study seeks to mimic bat echolocation behavior and flight under conditions of high interference, such as when large numbers of bats leave their roost together. The simulations convincingly suggest that the problem of acoustic jamming in these situations may be less severe than previously thought. This finding will be of broad interest to scientists working in the fields of bat biology and collective behaviour.

   Reviewed by eLife

4. MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio

   This article has 11 authors:

   1. Peipei Xu
   2. Rui Zhang
   3. Zhengrong Zhou
   4. Honglin Xu
   5. Yuejia Li
   6. Mengge Yang
   7. Ruifan Lin
   8. Yingchun Wang
   9. Xiahe Huang
   10. Qi Xie
   11. Wenxiang Meng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors propose that the kinase MARK2 regulates the Golgi's reorientation towards the cell's leading edge through the regulation of microtubule binding protein CAMSAP2 and its binding to USO1. While the model is interesting and the study is useful, the quantification of an insufficient number of cells and insufficient description of the methods and biological replicates mean the results are inadequate to support the model.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife

5. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   This article has 5 authors:

   1. Yamato Niitani
   2. Kohei Matsuzaki
   3. Erik Jonsson
   4. Ronald D Vale
   5. Michio Tomishige

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

6. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2303.14159v8

7. Movie reconstruction from mouse visual cortex activity

   This article has 3 authors:

   1. Joel Bauer
   2. Troy W Margrie
   3. Claudia Clopath

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses state-of-the-art neural encoding and video reconstruction methods to achieve a substantial improvement in video reconstruction quality from mouse neural data. It provides a convincing demonstration of how reconstruction performance can be improved by combining these methods. The goal of the study was improving reconstruction performance rather than advancing theoretical understanding of neural processing, so the results will be of practical interest to the brain decoding community.

   Reviewed by eLife

8. The C3-C3aR axis modulates trained immunity in alveolar macrophages

   This article has 10 authors:

   1. Alexander P Earhart
   2. Rafael Aponte Alburquerque
   3. Marick Starick
   4. Aasritha Nallapu
   5. Lorena Garnica
   6. Ayse Naz Ozanturk
   7. Rahul Kumar Maurya
   8. Xiaobo Wu
   9. Jeffrey A Haspel
   10. Hrishikesh S Kulkarni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study explores how complement protein C3 and its signalling may modulate immune training in alveolar macrophages. The findings are an important contribution to the field of trained immunity. The data presented is mainly solid, but incomplete in parts.

   Reviewed by eLife

9. Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions

   This article has 6 authors:

   1. Maria Gädeke
   2. Tom Eric Willems
   3. Omar Salah Ahmed
   4. Bernd Weber
   5. Rene Hurlemann
   6. Johannes Schultz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides valuable novel insights into the role of interpersonal guilt in social decision-making by showing that responsibility for a partner's bad lottery outcomes influences happiness. Through the integration of neuroimaging and computational modelling methods, and by combining findings from two studies, the authors provide solid support for their claims. The findings will be of interest to researchers in the field of social neuroscience and decision making.

   Reviewed by eLife

10. Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    This article has 10 authors:

    1. Jordan M Mancl
    2. Wenguang G Liang
    3. Nicholas L Bayhi
    4. Hui Wei
    5. William Budell
    6. Joshua H Mendez
    7. Tobin R Sosnick
    8. Bridget Carragher
    9. Clinton S Potter
    10. Wei-Jen Tang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The manuscript by Mancl et al. provides important mechanistic insights into the conformational dynamics of Insulin Degrading Enzyme (IDE), a zinc metalloprotease involved in the clearance of amyloid peptides. Supported by a compelling combination of time-resolved cryo-EM, SEC-SAXS, enzymatic assays, and both all-atom and coarse-grained simulations, the study reveals an insulin-induced allosteric transition and transient β-sheet interactions underlying IDE's unfoldase activity, thereby refining our understanding of IDE's functional cycle and offering a structural framework for developing substrate-selective modulators of M16 metalloproteases. The latest round of revisions further improves clarity and presentation by updating structural statistics, correcting minor textual inconsistencies, and refining supplemental materials, fully addressing the remaining reviewer comments.

    Reviewed by eLife