eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2025.05.27.656382

2. We couldn't get details of this article at this time:
   10.1101/2025.07.17.665269

3. We couldn't get details of this article at this time:
   10.1101/2025.07.02.662854

4. We couldn't get details of this article at this time:
   10.1101/2025.06.23.660389

5. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

   This article has 6 authors:

   1. Achal Mahajan
   2. Francesca Ratti
   3. Ban Wang
   4. Hana El-Samad
   5. James H Kaufman
   6. Vishrawas Gopalakrishnan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study analyzes aging-related chromatin changes through the lens of intra-chromosomal gene correlation length, which is a novel computational metric that captures spatial correlations in gene expression along the chromosome. The authors propose that this metric reflects chromatin structure and can serve as a proxy for its changes during aging. While currently the strength of evidence is somewhat incomplete, if revised with further supporting data, this work will provide a systems-level understanding of aging and genome regulation, which is predicted to have a substantive impact on the field.

   Reviewed by eLife

6. Regulation of Transcriptional Bursting and Spatial Patterning in Early Drosophila Embryo Development

   This article has 4 authors:

   1. César Nieto
   2. Zahra Vahdat
   3. Bomyi Lim
   4. Abhyudai Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable quantitative framework for analyzing transcription dynamics data for enhancers and genes expressed in the early Drosophila embryo. By analyzing existing data across both synthetic reporters and an endogenous gene (eve), this work provides evidence that spatial gene expression patterns within the embryo are largely determined by "activity time" - the time during which a gene is bursting. The methods and evidence are solid and should be of broad interest to researchers in developmental biology and quantitative gene regulation, but the study would be significantly enhanced by clarifying the novelty of the findings relative to prior work and presenting a rigorous benchmarking of their algorithm against previously used algorithms.

   Reviewed by eLife

7. A Python Toolbox for Representational Similarity Analysis

   This article has 11 authors:

   1. Jasper JF van den Bosch
   2. Tal Golan
   3. Benjamin Peters
   4. JohnMark Taylor
   5. Mahdiyar Shahbazi
   6. Baihan Lin
   7. Ian Charest
   8. Jörn Diedrichsen
   9. Nikolaus Kriegeskorte
   10. Marieke Mur
   11. Heiko H Schütt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a new toolbox for Representational Similarity Analysis, representing a valuable contribution to the neuroscience community. The authors offer a well-integrated platform that brings together a range of state-of-the-art methodological advances within a convincing framework, with strong potential to enable more rigorous and insightful analyses of neural data across multiple subfields.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.07.22.666189

9. A Priming Circuit Controls the Olfactory Response and Memory in Drosophila

   This article has 3 authors:

   1. He Yang
   2. Yang Jiang
   3. Samuel Kunes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work, combining behavioural genetics and calcium imaging, provides evidence for a form of learning in Drosophila that derives solely from direct or (optogenetically induced) phantom experience of punishment or reward. Flies that experience foot-shock alone show a subsequent decrease in avoidance to all odorants, together with increased odor-evoked activation of reward-encoding dopaminergic neurons that innervate the mushroom body. Phantom reward, delivered via optogenetic activation of reward-encoding dopaminergic neurons, increases subsequent odour-avoidance. While the findings are valuable to the field, there are aspects of the work that are incomplete, and some of the conclusions and terminology are also not completely justified; three major issues include : (a) the use of the term "priming" to describe this form of learning seems inappropriate and inconsistent with the accepted definition of this term; (b) a key 1998 publication with an initial description of this behavioural phenomenon needs to be cited and presented as context; and (c) the work on reward induced increase in odor-aversion seems relatively preliminary.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2025.05.12.653406