eLife

Latest preprint reviews

1. Rhythmic sampling and competition of target and distractor in a motion detection task

   This article has 6 authors:

   1. Changhao Xiong
   2. Nathan M Petro
   3. Ke Bo
   4. Lihan Cui
   5. Andreas Keil
   6. Mingzhou Ding

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important information on rhythmicity of overlapping target and distractor processing and how this affects behaviour. The methods are, in general, clearly laid out and defensible, with several supplementary analyses leading to a solid base of evidence for their claims.

   Reviewed by eLife

2. Premature vision drives aberrant development of response properties in primary visual cortex

   This article has 2 authors:

   1. Sophie V Griswold
   2. Stephen D Van Hooser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This carefully conducted study aims to understand how the early visual experience of premature infants induces lasting deficits, including compromised motion processing. The authors address this important question in a ferret animal model, exposing the developing visual system prematurely to patterned visual input by opening one or both eyes at a time when both retinal waves and light traveling through closed lids can drive sensory responses. Convincing evidence is presented, suggesting that eye opening at this time impacts temporal frequency tuning and elevates spontaneous firing rates. These findings will have great relevance for neuroscientists studying visual system development, particularly in the context of premature birth.

   Reviewed by eLife

3. Detecting behavioural oscillations with increased sensitivity: A modification of Brookshire’s (2022) AR-surrogate method

   This article has 2 authors:

   1. Anthony M Harris
   2. Henry A Beale

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study proposes an updated analysis technique that allows researchers to identify rhythms in behavior. If the proposed analyses control the rate of false positives, this will be an important contribution for all neuroscientists interested in rhythmic cognition. At present, the strength of evidence is incomplete, as the simulations ignore one crucial aspect of temporal structure in behavior.

   Reviewed by eLife

4. Overt visual attention modulates decision-related signals in ventral and dorsal medial prefrontal cortex

   This article has 4 authors:

   1. Blair RK Shevlin
   2. Rachael Gwinn
   3. Aidan Makwana
   4. Ian Krajbich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work examines the effects of gaze on valuation signals in the human brain as participants choose between bundles of sequentially presented items food items. The paper provides convincing analyses of how gaze affects participants choice behaviour and how this varies across time. The work will be of interest to neuroscientists working on attention and decision-making.

   Reviewed by eLife

5. CO2-dependent opening of Connexin 43 hemichannels

   This article has 8 authors:

   1. Valentin-Mihai Dospinescu
   2. Alexander Mascarenhas
   3. Jack Butler
   4. Sarbjit Nijjar
   5. Kyara de Oliveira Taborda
   6. Sean Connors
   7. Lumei Huang
   8. Nicholas Dale

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that connexin43 (Cx43) hemichannels are directly activated by CO₂ through a conserved carbamylation motif, extending a mechanism previously described for β-connexins to α-connexins. The evidence is convincing, supported by complementary biochemical and electrophysiological analyses showing CO₂-induced hemichannel opening and ATP release in cultured cells and hippocampal slices. These findings advance our understanding of connexin regulation by metabolic gases and will be of broad interest to researchers studying cell communication, neural signaling, and gasotransmitter biology.

   Reviewed by eLife

6. Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

   This article has 18 authors:

   1. Patrick B Jonker
   2. Mumina Sadullozoda
   3. Guillaume Cognet
   4. Juan J Apiz Saab
   5. Kelly H Sokol
   6. Violet X Wu
   7. Deepa Kumari
   8. Colin Sheehan
   9. Mete E Ozgurses
   10. Darby Agovino
   11. Grace Croley
   12. Smit A Patel
   13. Althea Bock-Hughes
   14. Kay F Macleod
   15. Hardik Shah
   16. Jonathan L Coloff
   17. Evan C Lien
   18. Alexander Muir

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and mouse models, the authors provide compelling evidence showing that arginine restriction in the microenvironment disrupts lipid homeostasis in PDAC, resulting in the induction of ferroptosis upon exposure of tumors to polyunsaturated fatty acids. This report is likely to be of broad interest to researchers interested in studying cancer biology, tumor microenvironment, metabolism, and stress adaptation mechanisms.

   Reviewed by eLife

7. KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

   This article has 19 authors:

   1. Lena Lau
   2. Kurt Henderson
   3. Ahu Turkoz
   4. Sara Linker
   5. Dorte Schlessinger
   6. Brad Townsley
   7. Brian Egan
   8. Shoba Ragunathan
   9. Robert Rollins
   10. Xianju Bi
   11. Zhijian J Chen
   12. Oleg Brodsky
   13. Clifford Restaino
   14. Murali Gururajan
   15. Kristen Jensen-Pergakes
   16. Anders Mälarstig
   17. Chames Kermi
   18. Paul Moore
   19. Marie Classon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that KDM5 inhibitors may enable a wide therapeutic window as compared to STING agonists or Type I Interferons. The evidence supporting the claims of the authors is convincing. The work will be of broad interest to scientists working in the field of breast cancer research.

   Reviewed by eLife

8. Task and Behavior-Related Variables Are Encoded by the Postrhinal and Medial Entorhinal Cortex During Non-Spatial Associative Learning

   This article has 9 authors:

   1. Ingeborg Nymoen Nystuen
   2. Frederik Sebastian Rogge
   3. Anna Hjertvik Aasen
   4. Sverre Grødem
   5. Anders Malthe-Sørenssen
   6. Mikkel Elle Lepperød
   7. Torkel Hafting
   8. Marianne Fyhn
   9. Kristian Kinden Lensjø

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how neural representations in the postrhinal and medial entorhinal cortices evolve with the learning of a visual associative memory task in mice. The findings provide new insights into how non-spatial information is differentially encoded across interconnected brain areas, with strong evidence that stimulus encoding is robust in the postrhinal cortex and emerges more weakly in the medial entorhinal cortex with learning. The evidence is solid overall, particularly in the use of sophisticated population-level analyses and two-photon imaging across learning phases, although the interpretation of regression models and clustering would benefit from additional clarity and control. The work will be of broad interest to systems neuroscientists studying learning, memory, and cortical circuit function.

   Reviewed by eLife

9. DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

   This article has 9 authors:

   1. Simar Pal Singh
   2. Michelle D van den Beukel
   3. Sjoerd van Deventer
   4. Marije B Overdijk
   5. M Guy Roukens
   6. Kim CM Santegoets
   7. Esther CW Breij
   8. Martin ter Beest
   9. Annemiek B van Spriel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of complement. The evidence supporting this mechanism is incomplete, with additional work needed to clarify SHP-1's role, the contribution of Fc receptor crosslinking, and the biological relevance across normal and malignant B cells. As the findings are based primarily on in vitro models, further validation would be required to support broader translational conclusions.

   Reviewed by eLife

10. Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping

    This article has 3 authors:

    1. Harrison A Grier
    2. Sohrab Salimian
    3. Matthew T Kaufman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The granularity with which neural activity in the sensorimotor cortex of mice corresponds to voluntary forelimb motion is a key open question. This paper provides compelling evidence for the encoding of low-level features like joint angles and represents an important step forward toward understanding cortical limb control signals.

    Reviewed by eLife