Synthetic Biology

  1. De novo design of modular and tunable allosteric biosensors

    1. Alfredo Quijano-Rubio
    2. Hsien-Wei Yeh
    3. Jooyoung Park
    4. Hansol Lee
    5. Robert A. Langan
    6. Scott E. Boyken
    7. Marc J. Lajoie
    8. Longxing Cao
    9. Cameron M. Chow
    10. Marcos C. Miranda
    11. Jimin Wi
    12. Hyo Jeong Hong
    13. Lance Stewart
    14. Byung-Ha Oh
    15. David Baker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii

    1. A. Berndt
    2. T. Smalley
    3. B. Ren
    4. A. Badary
    5. A. Sproles
    6. F. Fields
    7. Y. Torres-Tiji
    8. V. Heredia
    9. S. Mayfield

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

    1. Longxing Cao
    2. Inna Goreshnik
    3. Brian Coventry
    4. James Brett Case
    5. Lauren Miller
    6. Lisa Kozodoy
    7. Rita E. Chen
    8. Lauren Carter
    9. Alexandra C. Walls
    10. Young-Jun Park
    11. Eva-Maria Strauch
    12. Lance Stewart
    13. Michael S. Diamond
    14. David Veesler
    15. David Baker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality

    1. Jule Goike
    2. Ching-Lin Hsieh
    3. Andrew Horton
    4. Elizabeth C. Gardner
    5. Foteini Bartzoka
    6. Nianshuang Wang
    7. Kamyab Javanmardi
    8. Andrew Herbert
    9. Shawn Abbassi
    10. Rebecca Renberg
    11. Michael J. Johanson
    12. Jose A. Cardona
    13. Thomas Segall-Shapiro
    14. Ling Zhou
    15. Ruth H. Nissly
    16. Abhinay Gontu
    17. Michelle Byrom
    18. Andre C. Maranhao
    19. Anna M. Battenhouse
    20. Varun Gejji
    21. Laura Soto-Sierra
    22. Emma R. Foster
    23. Susan L. Woodard
    24. Zivko L. Nikolov
    25. Jason Lavinder
    26. Will N. Voss
    27. Ankur Annapareddy
    28. Gregory C. Ippolito
    29. Andrew D. Ellington
    30. Edward M. Marcotte
    31. Ilya J. Finkelstein
    32. Randall A. Hughes
    33. James M. Musser
    34. Suresh V. Kuchipudi
    35. Vivek Kapur
    36. George Georgiou
    37. John M. Dye
    38. Daniel R. Boutz
    39. Jason S. McLellan
    40. Jimmy D. Gollihar

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein

    1. Johannes Ruhnau
    2. Valerian Grote
    3. Mariana Juarez-Osorio
    4. Dunja Bruder
    5. Reza Mahour
    6. Erdmann Rapp
    7. Thomas F. T. Rexer
    8. Udo Reichl

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

    1. Zara Y. Weinberg
    2. Claire E. Hilburger
    3. Matthew Kim
    4. Longxing Cao
    5. Mir Khalid
    6. Sarah Elmes
    7. Devan Diwanji
    8. Evelyn Hernandez
    9. Jocelyne Lopez
    10. Kaitlin Schaefer
    11. Amber M. Smith
    12. Fengbo Zhou
    13. QCRG Structural Biology Consortium
    14. G. Renuka Kumar
    15. Melanie Ott
    16. David Baker
    17. Hana El-Samad

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

    1. Adi Idris
    2. Alicia Davis
    3. Aroon Supramaniam
    4. Dhruba Acharya
    5. Gabrielle Kelly
    6. Yaman Tayyar
    7. Nic West
    8. Ping Zhang
    9. Christopher L.D. McMillan
    10. Citradewi Soemardy
    11. Roslyn Ray
    12. Denis O’Meally
    13. Tristan A. Scott
    14. Nigel A.J. McMillan
    15. Kevin V. Morris

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Enhanced Cas12a multi-gene regulation using a CRISPR array separator

    1. Jens P Magnusson
    2. Antonio Ray Rios
    3. Lingling Wu
    4. Lei S Qi

    • Curated by eLife

      Evaluation Summary:

      This manuscript is of broad interest to those performing multiplexed genome engineering and related applications with CRISPR Cas12a technologies. While the proposed use of synSeparators is promising, the paper would benefit from further investigation of the mechanism by which synSeparators function to promote Cas12a activity. Additional data would be required to support the current conclusions regarding the generalizability of the findings.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    1. Phil Huss
    2. Anthony Meger
    3. Megan Leander
    4. Kyle Nishikawa
    5. Srivatsan Raman

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

    1. Shane Miersch
    2. Zhijie Li
    3. Reza Saberianfar
    4. Mart Ustav
    5. James Brett Case
    6. Levi Blazer
    7. Chao Chen
    8. Wei Ye
    9. Alevtina Pavlenco
    10. Maryna Gorelik
    11. Julia Garcia Perez
    12. Suryasree Subramania
    13. Serena Singh
    14. Lynda Ploder
    15. Safder Ganaie
    16. Rita E. Chen
    17. Daisy W. Leung
    18. Pier Paolo Pandolfi
    19. Giuseppe Novelli
    20. Giulia Matusali
    21. Francesca Colavita
    22. Maria R. Capobianchi
    23. Suresh Jain
    24. J.B. Gupta
    25. Gaya K. Amarasinghe
    26. Michael S. Diamond
    27. James Rini
    28. Sachdev S. Sidhu

    Reviewed by PREreview, ScreenIT

    2 evaluationsAppears in 2 listsLatest version Latest activity
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