Psychiatry and Clinical Psychology

SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

1. Rixing Lin
2. Aron Kos
3. Juan Pablo Lopez
4. Julien Dine
5. Laura M Fiori
6. Jennie Yang
7. Yair Ben-Efraim
8. Zahia Aouabed
9. Pascal Ibrahim
10. Haruka Mitsuhashi
11. Tak Pan Wong
12. El Cherif Ibrahim
13. Catherine Belzung
14. Pierre Blier
15. Faranak Farzan
16. Benicio N Frey
17. Raymond W Lam
18. Roumen Milev
19. Daniel J Muller
20. Sagar V Parikh
21. Claudio Soares
22. Rudolf Uher
23. Corina Nagy
24. Naguib Mechawar
25. Jane A Foster
26. Sidney H Kennedy
27. Alon Chen
28. Gustavo Turecki

• Curated by eLife

  eLife assessment

  This is an important study that uncovers a new molecular pathway that links traditional monoaminergic antidepressants with regulation of glutamate neurotransmission. The data provided for the model are convincing and demonstrate the pathway in human plasma and brain, mouse brain, and cultured cells, using the relative strengths of each system. The work will be of interest to psychiatrists studying depression as well as basic neurobiologists interested in monoamine signaling in the brain.

Reviewed by eLife

Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children

1. Chun Shen
2. Edmund T Rolls
3. Shitong Xiang
4. Christelle Langley
5. Barbara J Sahakian
6. Wei Cheng
7. Jianfeng Feng

• Curated by eLife

  eLife assessment

  The findings of this study yield important new insights into the relationship between the number of close friends and mental health, cognition, and brain structure. Due to the large sample sizes, the evidence is solid but would have been improved if both of the analyzed datasets contained more closely matched measures. This work advances our understanding of how the friendship network relates to young adolescents' mental well-being and cognitive functioning and their underlying neural mechanisms.

Reviewed by eLife

Psychological Resilience in Adolescence as a function of Genetic Risk for Major Depressive Disorder and Alzheimer’s Disease

1. Raluca Petrican
2. Alex Fornito

• Curated by eLife

  eLife assessment

  This work presents a multimodal approach to ascertain links between risk and resilience to depression and Alzheimer's disease in a large pediatric sample. The authors find two latent imaging variables that may be associated with resilience to adverse life events and disease risk, which show some spatial overlap with disease relevant gene-expression patterns and neurotransmitter expression. Such findings could be important for understanding mechanisms underlying resilience in neurological disorders, however, the analyses are inadequate for fully supporting the interpretation of the variables involved in these models, or for supporting some of the overall conclusions of the work.

Reviewed by eLife

Abnormalities in the migration of neural precursor cells in familial bipolar disorder

1. Salil K. Sukumaran
2. Pradip Paul
3. Vishwesha Guttal
4. Bharath Holla
5. Alekhya Vemula
6. Harsimar Bhatt
7. Piyush Bisht
8. Kezia Mathew
9. Ravi K. Nadella
10. Anu Mary Varghese
11. Vijayalakshmi Kalyan
12. Meera Purushottam
13. Sanjeev Jain
14. ADBS Consortium
15. Reeteka Sud
16. Biju Viswanath

Reviewed by PeerRef

Attention-deficit hyperactivity disorder symptoms and brain morphology: Examining confounding bias

1. Lorenza Dall'Aglio
2. Hannah H Kim
3. Sander Lamballais
4. Jeremy Labrecque
5. Ryan L Muetzel
6. Henning Tiemeier

• Curated by eLife

  Evaluation Summary:

  This study will be of interest to the large class of researchers who perform brain-behavior correlation analysis in the neuroimaging field, especially those related to neurodevelopment. The authors found that controlling for socioeconomic and maternal behavioral confounders, in addition to the usual demographic variables, generally attenuated such associations in ADHD using two independent large cohorts. The findings highlighted the importance of careful confounder selection and control for robust brain-behavior associations.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Prevalence and determinants of mental well-being and satisfaction with life among university students amidst COVID-19 pandemic

1. Md. Safaet Hossain Sujan
2. Atefehsadat Haghighathoseini
3. Rafia Tasnim
4. Rezaul Karim Ripon
5. Sayem Ahmed Ripon
6. Mohammad Mohiuddin Hasan
7. Muhammad Ramiz Uddin
8. Most. Zannatul Ferdous

Reviewed by ScreenIT

Effects of social support on depression risk during the COVID-19 pandemic: What support types and for whom?

1. Karmel W. Choi
2. Younga H. Lee
3. Zhaowen Liu
4. Daniel Fatori
5. Joshua R. Bauermeister
6. Rebecca A. Luh
7. Cheryl R. Clark
8. André R. Brunoni
9. Sarah Bauermeister
10. Jordan W. Smoller

Reviewed by ScreenIT

Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies

1. Ellen J Thompson
2. Jean Stafford
3. Bettina Moltrecht
4. Charlotte F Huggins
5. Alex S F Kwong
6. Richard J Shaw
7. Paola Zaninotto
8. Kishan Patel
9. Richard J Silverwood
10. Eoin McElroy
11. Matthias Pierce
12. Michael J Green
13. Ruth C E Bowyer
14. Jane Maddock
15. Kate Tilling
16. S Vittal Katikireddi
17. George B Ploubidis
18. David J Porteous
19. Nic Timpson
20. Nish Chaturvedi
21. Claire J Steves
22. Praveetha Patalay

Reviewed by ScreenIT

Acceptability of a behavioural intervention to mitigate the psychological impacts of COVID-19 restrictions in older people with long-term conditions: a qualitative study

1. Leanne Shearsmith
2. Peter A Coventry
3. Claire Sloan
4. Andrew Henry
5. Liz Newbronner
6. Elizabeth Littlewood
7. Della Bailey
8. Samantha Gascoyne
9. Lauren Burke
10. Eloise Ryde
11. Rebecca Woodhouse
12. Dean McMillan
13. David Ekers
14. Simon Gilbody
15. Carolyn Chew-Graham

Reviewed by ScreenIT

Mental-health before and during the COVID-19 pandemic in adults with neurodevelopmental disorders

1. Amy Shakeshaft
2. Rachel Blakey
3. Alex S.F. Kwong
4. Lucy Riglin
5. George Davey Smith
6. Evie Stergiakouli
7. Kate Tilling
8. Anita Thapar

Reviewed by ScreenIT