Pathology

Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD

1. Jia He
2. Ran Li
3. Cheng Xie
4. Xiane Zhu
5. Keqin Wang
6. Zhao Shan

• Curated by eLife

  eLife Assessment

  The authors aim to understand why Kupffer cells (KCs) die in metabolic-associated steatotic liver disease (MASLD). This is a useful study using in vitro studies and an in vivo genetic mouse model, suggesting that increased glycolysis contributes to KC death in MASLD. However, the data presented are incomplete as some inconsistencies in the results presented are identified in the characterisation of KCs. This work will be of interest to researchers in the immunology and metabolism fields.

Reviewed by eLife

Protective role of RIPK1 scaffolding against HDV-induced hepatocyte cell death and the significance of cytokines in mice

1. Gracián Camps
2. Sheila Maestro
3. Laura Torella
4. Diego Herrero
5. Carla Usai
6. Martin Bilbao-Arribas
7. Ana Aldaz
8. Cristina Olagüe
9. Africa Vales
10. Lester Suárez-Amarán
11. Rafael Aldabe
12. Gloria Gonzalez-Aseguinolaza

Reviewed by Rapid Reviews Infectious Diseases

R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease

1. Trevor Fisher
2. Mehaben Patel
3. Shalaka Deshmukh
4. Darshini Shah
5. Chenggang Lu
6. Maureen Newman
7. Jay Ye
8. Russell Fletcher
9. Geertrui F Vanhove
10. Jay Tibbitts
11. Yang Li
12. Nicholas J Skill
13. Zhihong Yang
14. Suthat Liangpunsakul
15. Helene Baribault

• Curated by eLife

  eLife Assessment

  This important study highlights the novel role of RSPO mimetic SZN-043 in the activation of hepatic WNT signaling and promoting hepatocyte regeneration. The authors provide convincing evidence of SZN-043 increasing hepatocytes proliferation in various mouse models, including a humanized mouse liver model, ALD model and CCL4 fibrosis model. This study will be of interest to researchers in liver regeneration and repair mechanisms.

Reviewed by eLife

Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

1. Qian Xiu
2. Xiaoru Yin
3. Yuanyuan Chen
4. Ziyang Zhang
5. Yushuai Mao
6. Tianshi Wang
7. Jie Zhang
8. Mingguo Zhou
9. Yabing Duan

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors show the physiological response and molecular pathway mediating the effect of quinofumelin, a developed fungicide with an unknown mechanism. The authors present convincing data suggesting the involvement of the uridine/uracil biosynthesis pathway, by combining in vivo microbiology characterization as well as in vitro biochemical binding results.

Reviewed by eLife

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

1. Giulia Allavena
2. Francesca Rossiello
3. Aurora Irene Idilli
4. Marina Mione
5. Fabrizio d’Adda di Fagagna
6. Miguel Godinho Ferreira
7. Bruno Lopes-Bastos

Reviewed by preLights

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

1. Wenqin Fang
2. Xiaoyu Zai
3. Jia Chen
4. Yakubu Saddeeq Abubakar
5. Qiuqiu Wu
6. Zhenyu Fang
7. Xiuwei Huang
8. Xiang Gan
9. Daniel J Ebbole
10. Zonghua Wang
11. Wenhui Zheng

• Curated by eLife

  eLife Assessment

  This valuable study provides strong evidence for the development of a penetration ring during Magnaporthe oryzae infection and, supported by knockout and expression studies, shows that Ppe1 is involved in the virulence of the fungus. Although the authors demonstrated the close association of Ppe1 with the host plasma membrane, the work fell short in providing direct evidence for its role at the host-pathogen interface and the precise molecular function of the penetration ring. Therefore, the study presented strong structural and phenotypic characterization but remains incomplete regarding mechanistic insights of Ppe1.

Reviewed by eLife

mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

1. Philip Stavrides
2. Chris N Goulbourne
3. James Peddy
4. Chunfeng Huo
5. Mala Rao
6. Vinod Khetarpal
7. Deanna M Marchionini
8. Ralph A Nixon
9. Dun-Sheng Yang

• Curated by eLife

  eLife Assessment

  This study presents an important finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is convincing. The original reviewers have found most of the issues previously raised have been addressed although further suggestions are given for consideration. These comments are listed below. The work will be of interest to neuroscientists working on HD.

Reviewed by eLife

Pathology of Influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission

1. Carla Fiorito
2. Ana Colom
3. Antonio Fernández
4. Paula Alonso-Almorox
5. Marisa Andrada
6. Daniel Lombardo
7. Eva Sierra

Reviewed by Rapid Reviews Infectious Diseases, PREreview

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

1. Linsey Peters
2. Leonida Rakateli
3. Rosanna Huchzermeier
4. Andrea Bonnin-Marquez
5. Sanne L Maas
6. Cheng Lin
7. Alexander Jans
8. Yana Geng
9. Alan Gorter
10. Marion Gijbels
11. Sander Rensen
12. Peter Olinga
13. Tim Hendrikx
14. Marcin Krawczyk
15. Malvina Brisbois
16. Joachim Jankowski
17. Kiril Bidzhekov
18. Christian Weber
19. Erik AL Biessen
20. Ronit Shiri-Sverdlov
21. Tom Houben
22. Yvonne Döring
23. Matthias Bartneck
24. Emiel van der Vorst

• Curated by eLife

  eLife Assessment

  This study presents valuable insights into the involvement of miR-26b in the progression of metabolic dysfunction-associated steatohepatitis (MASH). The delivery of microRNA-containing nanoparticles to reduce MASH severity has practical implications as a therapeutic strategy. The authors use two sets of transgenic mouse models, conducted kinase activity profiling of mouse liver samples, and supplemented their findings with additional experiments on human liver and plasma, providing solid support for their findings.

Reviewed by eLife

Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

1. Marketa Jirouskova
2. Karel Harant
3. Pavel Cejnar
4. Srikant Ojha
5. Katerina Korelova
6. Lenka Sarnova
7. Eva Sticova
8. Christoph H Mayr
9. Herbert B Schiller
10. Martin Gregor

• Curated by eLife

  eLife Assessment

  This important study suggests that the composition of the extracellular matrix in a mouse model of liver fibrosis changes depending on the cause of liver fibrosis. The data could be used as a foundation for future antifibrotic therapies. The strength of evidence is convincing with respect to the use of animal models and proteomic analysis. The study provides a helpful inventory of proteins up or down-regulated.

Reviewed by eLife