Pathology

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

1. Linsey JF Peters
2. Leonida Rakateli
3. Rosanna Huchzermeier
4. Andrea Bonnin-Marquez
5. Sanne L Maas
6. Cheng Lin
7. Alexander Jans
8. Yana Geng
9. Alan Gorter
10. Marion J Gijbels
11. Sander S Rensen
12. Peter Olinga
13. Tim Hendrikx
14. Marcin Krawczyk
15. Malvina Brisbois
16. Joachim Jankowski
17. Kiril Bidzhekov
18. Christian Weber
19. Erik AL Biessen
20. Ronit Shiri-Sverdlov
21. Tom Houben
22. Yvonne Döring
23. Matthias Bartneck
24. Emiel PC van der Vorst

• Curated by eLife

  eLife Assessment

  This study presents valuable insights into the involvement of miR-26b in the progression of metabolic dysfunction-associated steatohepatitis (MASH). The delivery of microRNA-containing nanoparticles to reduce MASH severity has practical implications as a therapeutic strategy. The authors use two sets of transgenic mouse models, conducted kinase activity profiling of mouse liver samples, and supplemented their findings with additional experiments on human liver and plasma, providing solid support for their findings.

Reviewed by eLife

Pathology of Influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission

1. Carla Fiorito
2. Ana Colom
3. Antonio Fernández
4. Paula Alonso-Almorox
5. Marisa Andrada
6. Daniel Lombardo
7. Eva Sierra

Reviewed by PREreview

Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

1. Qian Xiu
2. Xiaoru Yin
3. Yuanyuan Chen
4. Ziyang Zhang
5. Yushuai Mao
6. Tianshi Wang
7. Jie Zhang
8. Mingguo Zhou
9. Yabing Duan

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors show the physiological response and molecular pathway mediating the effect of quinofumelin, a developed fungicide with an unknown mechanism. The authors present convincing data suggesting the involvement of the uridine/uracil biosynthesis pathway, by combining in vivo microbiology characterization as well as in vitro biochemical binding results.

Reviewed by eLife

Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

1. Marketa Jirouskova
2. Karel Harant
3. Pavel Cejnar
4. Srikant Ojha
5. Katerina Korelova
6. Lenka Sarnova
7. Eva Sticova
8. Christoph H Mayr
9. Herbert B Schiller
10. Martin Gregor

• Curated by eLife

  eLife Assessment

  This important study suggests that the composition of the extracellular matrix in a mouse model of liver fibrosis changes depending on the cause of liver fibrosis. The data could be used as a foundation for future antifibrotic therapies. The strength of evidence is convincing with respect to the use of animal models and proteomic analysis. The study provides a helpful inventory of proteins up or down-regulated.

Reviewed by eLife

R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease

1. Trevor Fisher
2. Mehaben Patel
3. Shalaka Deshmukh
4. Darshini Shah
5. Chenggang Lu
6. Maureen Newman
7. Jay Ye
8. Russell Fletcher
9. Geertrui F Vanhove
10. Jay Tibbitts
11. Yang Li
12. Nicholas J Skill
13. Zhihong Yang
14. Suthat Liangpunsakul
15. Helene Baribault

• Curated by eLife

  eLife Assessment

  This important study highlights the novel role of RSPO mimetic SZN-043 in the activation of hepatic WNT signaling and promoting hepatocyte regeneration. The authors provided solid evidence of SZN-043 increasing hepatocyte proliferation in various mouse models, including a humanized mouse liver model, ALD model, and CCL4 fibrosis model, although mechanistic characterization of liver pathology remains incomplete. This study will be of interest to researchers in liver regeneration and repair mechanisms.

Reviewed by eLife

mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

1. Philip Stavrides
2. Chris N. Goulbourne
3. James Peddy
4. Chunfeng Huo
5. Mala Rao
6. Vinod Khetarpal
7. Deanna M. Marchionini
8. Ralph A. Nixon
9. Dun-Sheng Yang

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the observed changes in autophagy are moderate, the images were not fully represented by the quantification results, and some of the short forms used in the text are not clearly stated; these issues hinder further evaluation of the claims. The work will be of interest to neuroscientists working on HD.

Reviewed by eLife

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit

1. Nobuyuki Oguri
2. Toshihiro Gi
3. Eriko Nakamura
4. Kazunari Maekawa
5. Eiji Furukoji
6. Hoshimi Okawa
7. Sho Kouyama
8. Saki Horiuchi
9. Tatefumi Sakae
10. Minako Azuma
11. Yujiro Asada
12. Atsushi Yamashita

Reviewed by preLights

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis

1. Ben Higgins
2. Ioannis Simitsidellis
3. Xiaozhong Zheng
4. Frances Collins
5. Natalie ZM Homer
6. Scott G Denham
7. Joanna P Simpson
8. Mike Millar
9. Lyndsey Boswell
10. Hee Y Lee
11. Yeon G Kim
12. Kyung H Park
13. Larry C Park
14. Patrick J Sweeney
15. Gerard Feraille
16. Alessandro Taddei
17. David Chagras
18. Thierry Alvarez
19. Scott P Webster
20. Andrew Horne
21. Philippa TK Saunders
22. Damian J Mole

• Curated by eLife

  eLife Assessment

  This useful study holds importance within the focused scope of endometriosis treatment, providing initial evidence of a potential new therapeutic target. The strength of the evidence is solid, as the methods, data, and analyses support the authors' conclusions regarding the specific aims. The study provides promising preliminary evidence of KMO implication in endometriosis, but it falls short of establishing a strong rationale for proposing KNS898 as a treatment for endometriosis given the limitations in evidence and mechanistic insights.

Reviewed by eLife

Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

1. Jeong-Oh Shin
2. Jong-Bin Lee
3. Sihoon Lee
4. Jin-Woo Kim

• Curated by eLife

  eLife Assessment

  Using a large animal model, this study demonstrated valuable findings that R25CPTH(1-34), based on a mutation associated with isolated familial hypoparathyroidism, generated an anabolic osteointegration effect comparable to that of native PTH1-34. The translational aspect of this human-to-animal work, aimed at animal-to-human translation for therapeutic purposes, should be highlighted. The study design is simple and straightforward, and the methods used are solid. The authors have addressed all the questions in their revision.

Reviewed by eLife

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

1. Wenqin Fang
2. Xiaoyu Zai
3. Jia Chen
4. Yakubu Saddeeq Abubakar
5. Qiuqiu Wu
6. Zhenyu Fang
7. Xiuwei Huang
8. Xiang Gan
9. Daniel J Ebbole
10. Zonghua Wang
11. Wenhui Zheng

• Curated by eLife

  eLife assessment

  This study describes the formation of a penetration ring in the rice blast fungus Magnaporthe oryzae during host cell invasion. The work provides useful insights into how the penetration ring facilitates the transition of penetration pegs into invasive hyphae, which leads to a better understanding of plant-pathogen interactions. However, the evidence supporting the function of this novel infection structure remains incomplete and further work is needed to help clarify the exact role of the penetration ring in the infection process.

Reviewed by eLife