1. Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25C PTH(1-34) in an Osteoporotic Beagle Model

    This article has 4 authors:
    1. Jeong-Oh Shin
    2. Jong-Bin Lee
    3. Sihoon Lee
    4. Jin-Woo Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work by Shin et al. demonstrated that a different form of PTH (R25C PTH) generated a comparable anabolic signal to rhPTH 1-34 using a large animal model. This valuable finding may have therapeutic potential in promoting bone formation or the healing process, and the methods seem solid, although there remains a concern regarding the small sample size and surgical procedure.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

    This article has 21 authors:
    1. Paul Horn
    2. Jenny Norlin
    3. Kasper Almholt
    4. Birgitte M Viuff
    5. Elisabeth D Galsgaard
    6. Andreas Hald
    7. Franziska Zosel
    8. Helle Demuth
    9. Svend Poulsen
    10. Peder L Norby
    11. Morten G Rasch
    12. Mogens Vyberg
    13. Mikkel Parsberg Werge
    14. Lise Lotte Gluud
    15. Marco R Rink
    16. Emma Shepherd
    17. Ellie Northall
    18. Patricia F Lalor
    19. Chris J Weston
    20. Morten Fog-Tonnesen
    21. Philip N Newsome
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important paper shows that the anti-gremlin-1 (GREM1) antibody is not effective at treating liver inflammation or fibrosis. Critically, the evidence also challenges existing data on the detection of GREM1 by ELISA in serum or plasma by demonstrating that high-affinity binding of GREM1 to heparin would lead to localisation of GREM1 in the ECM or at the plasma membrane of cells. The conclusions are supported by a convincing, well-controlled set of experiments.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Protective Role of RIPK1 Scaffolding against HDV-Induced Hepatocyte cell death and the Significance of Cytokines in Mice

    This article has 12 authors:
    1. Gracián Camps
    2. Sheila Maestro
    3. Laura Torella
    4. Carla Usai
    5. Ana Aldaz
    6. Cristina Olagüe
    7. Africa Vales
    8. Anne Montfort
    9. Bruno Ségui
    10. Lester Suarez
    11. Rafael Aldabe
    12. Gloria Gonzalez-Aseguinolaza

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  4. PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

    This article has 17 authors:
    1. Teruhiko Yoshida
    2. Khun Zaw Latt
    3. Avi Z. Rosenberg
    4. Briana A. Santo
    5. Komuraiah Myakala
    6. Yu Ishimoto
    7. Yongmei Zhao
    8. Shashi Shrivastav
    9. Bryce A. Jones
    10. Xiaoping Yang
    11. Xiaoxin X. Wang
    12. Vincent M. Tutino
    13. Pinaki Sarder
    14. Moshe Levi
    15. Koji Okamoto
    16. Cheryl A. Winkler
    17. Jeffrey B. Kopp
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable new insights into a HIV-associated nephropathy (HIVAN) kidney phenotype in the Tg26 transgenic mouse model, and delineates the kidney cell types that express HIV genes and are injured in these HIV-transgenic mice. A series of compelling experiments demonstrated that PKR inhibition can ameliorate HIVAN with reversal of mitochondrial dysfunction (mainly confined to endothelial cells), a prominent feature shared in other kidney diseases. The data support that inhibition of PKR and mitochondrial dysfunction has potential clinical significance for HIVAN.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

    This article has 12 authors:
    1. Wei Chen
    2. Yun Lu
    3. Yan Zhang
    4. Jinjin Wu
    5. Abigail McVicar
    6. Yilin Chen
    7. Siyu Zhu
    8. Guochun Zhu
    9. You Lu
    10. Jiayang Zhang
    11. Matthew McConnell
    12. Yi-Ping Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental work advances our understanding of the role of Cbfβ in maintaining articular cartilage homeostasis and the underlying mechanisms. The evidence supporting the conclusion is mostly convincing, although including additional experiments and discussions would have strengthened the study. This paper is of potential interest to skeletal biologists and orthopaedic surgeons who study the pathogenesis and the therapeutics of osteoarthritis.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

    This article has 24 authors:
    1. Venkateshwari Varadharajan
    2. Iyappan Ramachandiran
    3. William J Massey
    4. Raghav Jain
    5. Rakhee Banerjee
    6. Anthony J Horak
    7. Megan R McMullen
    8. Emily Huang
    9. Annette Bellar
    10. Shuhui W Lorkowski
    11. Kailash Gulshan
    12. Robert N Helsley
    13. Isabella James
    14. Vai Pathak
    15. Jaividhya Dasarathy
    16. Nicole Welch
    17. Srinivasan Dasarathy
    18. David Streem
    19. Ofer Reizes
    20. Daniela S Allende
    21. Jonathan D Smith
    22. Judith Simcox
    23. Laura E Nagy
    24. J Mark Brown
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Varadharajan et al. explore the mechanistic basis of MBOAT7 SNP association with steatotic liver disease and link its function in LPI acylation to altered lipidomics of endosomal/lysosomal system and impaired TFEB mediated lysosomal biogenesis. The findings are important with theoretical and practical implications in MAFLD, alcohol-induced hepatic steatosis, and lysosomal diseases. The strength of evidence is convincing using methodology in line with current state-of-the-art.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  7. Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    This article has 7 authors:
    1. Won Yeong Park
    2. Jieun Yun
    3. Jinho Shin
    4. Byung Ho Oh
    5. Gilsuk Yoon
    6. Seung-Mo Hong
    7. Ki Hean Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work by Park et al. demonstrates an open-top two-photon light sheet microscopy (OT-TP-LSM) for lesser invasive evaluation of intraoperative 3D pathology. The authors provide convincing evidence for the effectiveness of this technique investigating various human cancer cells. This article will be of broad interest to biologists and, specifically, pathologists utilizing 3D optical microscopy.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. The intricate relationship of G-Quadruplexes and bacterial pathogenicity islands

    This article has 2 authors:
    1. Bo Lyu
    2. Qisheng Song
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study explores the relationship between guanine-quadruplex structures and pathogenicity islands in 89 bacterial strains representing a range of pathogens. Guanine-quadruplex structures were found to be non-randomly distributed within pathogenicity islands and conserved within the same strains. These compelling findings shed light on the molecular mechanisms of Guanine-quadruplex structure-pathogenicity island interactions and will be of interest to all microbiologists.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

    This article has 14 authors:
    1. Chenjie Xia
    2. Huihui Xu
    3. Liang Fang
    4. Jiali Chen
    5. Wenhua Yuan
    6. Danqing Fu
    7. Xucheng Wang
    8. Bangjian He
    9. Luwei Xiao
    10. Chengliang Wu
    11. Peijian Tong
    12. Di Chen
    13. Pinger Wang
    14. Hongting Jin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on the mechanism of glucocorticoid-induced osteonecrosis of the femoral head. The data were collected and analyzed using solid, validated methodology and can be used as a starting point for functional studies of development of glucocorticoid-induced osteonecrosis. This paper would be of interest to cell biologists and biophysicists working on potential pharmacological treatments for glucocorticoid-induced osteonecrosis.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    This article has 12 authors:
    1. Lutian Yao
    2. Jiawei Lu
    3. Leilei Zhong
    4. Yulong Wei
    5. Tao Gui
    6. Luqiang Wang
    7. Jaimo Ahn
    8. Joel D Boerckel
    9. Danielle Rux
    10. Christina Mundy
    11. Ling Qin
    12. Maurizio Pacifici
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work is a valuable presentation of sharp-wave-ripple reactivation of hippocampal neural ensemble activity recorded as animals explored two different environments. It attempts to use the fact that the ensemble code remaps between the two mazes to identify the best replay-detection procedures for analyzing this type of data. The reviewers found the evidence for a prescriptive conclusion inadequate, while still appreciating the concept of comparing maze-identity discrimination with replay.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity