Pathology

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

1. Giulia Allavena
2. Francesca Rossiello
3. Aurora Irene Idilli
4. Marina Mione
5. Fabrizio d’Adda di Fagagna
6. Miguel Godinho Ferreira
7. Bruno Lopes-Bastos

Reviewed by preLights

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

1. Wenqin Fang
2. Xiaoyu Zai
3. Jia Chen
4. Yakubu Saddeeq Abubakar
5. Qiuqiu Wu
6. Zhenyu Fang
7. Xiuwei Huang
8. Xiang Gan
9. Daniel J Ebbole
10. Zonghua Wang
11. Wenhui Zheng

• Curated by eLife

  eLife Assessment

  This valuable study provides strong evidence for the development of a penetration ring during Magnaporthe oryzae infection and, supported by knockout and expression studies, shows that Ppe1 is involved in the virulence of the fungus. Although the authors demonstrated the close association of Ppe1 with the host plasma membrane, the work fell short in providing direct evidence for its role at the host-pathogen interface and the precise molecular function of the penetration ring. Therefore, the study presented strong structural and phenotypic characterization but remains incomplete regarding mechanistic insights of Ppe1.

Reviewed by eLife

Pathology of Influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission

1. Carla Fiorito
2. Ana Colom
3. Antonio Fernández
4. Paula Alonso-Almorox
5. Marisa Andrada
6. Daniel Lombardo
7. Eva Sierra

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis

1. Nobuyuki Oguri
2. Toshihiro Gi
3. Eriko Nakamura
4. Kazunari Maekawa
5. Eiji Furukoji
6. Hoshimi Okawa
7. Sho Kouyama
8. Saki Horiuchi
9. Akira Sawaguchi
10. Tatefumi Sakae
11. Minako Azuma
12. Yujiro Asada
13. Atsushi Yamashita

Reviewed by preLights

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis

1. Ben Higgins
2. Ioannis Simitsidellis
3. Xiaozhong Zheng
4. Frances Collins
5. Natalie ZM Homer
6. Scott G Denham
7. Joanna P Simpson
8. Mike Millar
9. Lyndsey Boswell
10. Hee Y Lee
11. Yeon G Kim
12. Kyung H Park
13. Larry C Park
14. Patrick J Sweeney
15. Gerard Feraille
16. Alessandro Taddei
17. David Chagras
18. Thierry Alvarez
19. Scott P Webster
20. Andrew Horne
21. Philippa TK Saunders
22. Damian J Mole

• Curated by eLife

  eLife Assessment

  This useful study holds importance within the focused scope of endometriosis treatment, providing initial evidence of a potential new therapeutic target. The strength of the evidence is solid, as the methods, data, and analyses support the authors' conclusions regarding the specific aims. The study provides promising preliminary evidence of KMO implication in endometriosis, but it falls short of establishing a strong rationale for proposing KNS898 as a treatment for endometriosis given the limitations in evidence and mechanistic insights.

Reviewed by eLife