Neuroscience

  4. Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

    1. Yingying Chen
    2. Jeong Han Lee
    3. Jin Li
    4. Seojin Park
    5. Maria C Perez Flores
    6. Braulio Peguero
    7. Jennifer Kersigo
    8. Mincheol Kang
    9. Jinsil Choi
    10. Lauren Levine
    11. Michael Anne Gratton
    12. Bernd Fritzsch
    13. Ebenezer N Yamoah

    • Curated by eLife

      eLife Assessment

      This valuable study reports the induction of supernumerary inner hair cells in the mouse cochlea upon reducing the expression level of a tight-junction protein (claudin-9) at developmental stages. Although these ectopic hair cells are functional and persists through adulthood, the evidence supporting some of the claims is incomplete, particularly regarding the underlying mechanisms of cell differentiation and the potential of the approach for hair-cell regeneration. The work will be of interest to scientists working in the development and regeneration of hair cells in the inner ear.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  9. Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models

    1. Nalini R. Rao
    2. Olivia DeGulis
    3. Toshihiro Nomura
    4. SeungEun Lee
    5. Timothy J. Hark
    6. Justin C. Dynes
    7. Emily X. Dexter
    8. Maciej Dulewicz
    9. Junyue Ge
    10. Arun Upadhyay
    11. Eugenio F. Fornasiero
    12. Robert Vassar
    13. Jörg Hanrieder
    14. Anis Contractor
    15. Jeffrey N. Savas

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity
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