Neuroscience

The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

1. Lian Hollander-Cohen
2. Omer Cohen
3. Miriam Shulman
4. Tomer Aiznkot
5. Pierre Fontanaud
6. Omer Revah
7. Patrice Mollard
8. Matan Golan
9. Berta Levavi-Sivan

• Curated by eLife

  eLife Assessment

  This study presents valuable findings on the role of the satiety hormone cholecystokinin typically associated with feeding in the control of a pituitary hormone, FSH, which is a critical regulator of reproductive physiology. The authors provide solid pharmacological evidence that cholecystokinin is sufficient to regulate FSH and compelling genetic evidence that one of its receptors is required for gonadal development, with uncertainties remaining about the physiological regulation and necessity of the peptide. The work will be of interest to reproductive biologists, especially those with an interest in the endocrine control of fertility.

Reviewed by eLife

Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

1. Jan H Kirchner
2. Lucas Euler
3. Ingo Fritz
4. André Ferreira Castro
5. Julijana Gjorgjieva

• Curated by eLife

  eLife Assessment

  This important work investigates how two distinct processes, morphological changes and synaptic plasticity, contribute to the final shape of neuronal dendrites and the spatial structure of their synaptic inputs. The modelling is convincing and could be broadly applied to other similar questions. The work will be of interest to neuroscientists studying dendritic development and connectivity at a single-cell level.

Reviewed by eLife

Mid1 deletion leads to cognitive dysfunction in Opitz syndrome by regulates neural rhythms through the inhibition of p-Creb by PP2Ac

1. Ziye Yang
2. Pengxiang Li
3. Yue Chen
4. Xiaoyu Guo
5. Ping Liu
6. Guangjian Ni
7. Shuang Liu
8. Liqun Chen
9. Dong Ming

• Curated by eLife

  eLife Assessment

  This study provides important insights into the role of the Mid1 gene in hippocampal development and its implications in Opitz G/BBB syndrome, with much evidence supporting its impact on synaptic plasticity, neural rhythms, and cognitive functions. The methods, data, and analyses are solid, supporting the claims, presenting several minor weaknesses, and establishing Mid1 as a potential therapeutic target for neurological deficits associated with OS. The conclusions are largely supported by the results, but additional data are needed.

Reviewed by eLife

Multiple and subject-specific roles of uncertainty in reward-guided decision-making

1. Alexander Paunov
2. Maëva L’Hôtellier
3. Dalin Guo
4. Zoe He
5. Angela Yu
6. Florent Meyniel

• Curated by eLife

  eLife Assessment

  The findings of this study are valuable, as they address a critical methodological gap in decision-making research by demonstrating how heuristic strategies can confound interpretations of uncertainty-driven behaviour and provide a clearer framework for distinguishing between uncertainty-seeking and heuristic-driven exploration. While the evidence is solid, with strong methodological rigour in task design and computational modelling, some claims, such as the stability of uncertainty parameters and correlations with psychopathology measures, require refinement. Overall, the data broadly support the study's claims, but interpretational ambiguities limit the impact of certain findings.

Reviewed by eLife

A brainstem circuit controls cough-like airway defensive behaviors in mice

1. Xiaoshan Xu
2. Xiupeng Nie
3. Weijia Zhang
4. He-Hai Jiang
5. Bingyi Liu
6. Yanyan Ren
7. Tingting Wang
8. Xiang Xu
9. Jing Yang
10. Fujun Luo

• Curated by eLife

  eLife Assessment

  This valuable study by Xu and colleagues investigates brainstem circuits mediating evoked respiratory reflexes that they define as cough-like in a freely behaving mouse model. They have applied multiple circuit mapping and manipulation approaches to suggest that the caudal spinal trigeminal nucleus (SP5C) nucleus can play a novel role in generating a reflex cough-like behavior in mice. The authors give incomplete evidence that the reflex behavior produced in their mouse model is definitively cough, limiting functional interpretation of the putative circuit identified and requiring more thorough experimental interrogation of the behavior studied.

Reviewed by eLife

Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo

1. Siân Wilson
2. Daan Christiaens
3. Hyukjin Yun
4. Alena Uus
5. Lucilio Cordero-Grande
6. Vyacheslav Karolis
7. Anthony Price
8. Maria Deprez
9. Jacques-Donald Tournier
10. Mary Rutherford
11. Ellen Grant
12. Joseph V Hajnal
13. A David Edwards
14. Tomoki Arichi
15. Jonathan O’Muircheartaigh
16. Kiho Im

• Curated by eLife

  eLife Assessment

  This study presents a valuable study of early brain development using advanced MRI methods. In particular, the study investigates the relationship between the maturation of diffusion MRI tissue properties and suggests that they may precede and guide the emergence of brain folding patterns. The data is solid, however, the evidence supporting the precedence of tissue changes over brain folding appears incomplete.

Reviewed by eLife

Nonlinear brain connectivity from neurons to networks: quantification, sources and localization

1. Giulio Tani Raffaelli
2. Stanislav Jiříček
3. Jaroslav Hlinka

Reviewed by PREreview

Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

1. Zak Buhmann
2. Amanda K Robinson
3. Jason B Mattingley
4. Reuben Rideaux

• Curated by eLife

  eLife Assessment

  Despite the well-established facilitatory effects of multisensory integration on behavioural measures, standard neuroimaging approaches have yet to reliably and precisely identify the corresponding neural correlates. In this valuable paper, Buhmann et al. leverage EEG decoding methods, moving beyond traditional univariate analyses, to capture these correlates. They present solid evidence that this approach can effectively estimate multisensory integration in humans across a broad range of contexts.

Reviewed by eLife

It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

1. Spencer S Abssy
2. Natalie R Osborne
3. Evgeny E Osokin
4. Rossi Tomin
5. Liat Honigman
6. James S Khan
7. Nathaniel W De Vera
8. Andrew Furman
9. Ali Mazaheri
10. David A Seminowicz
11. Massieh Moayedi

• Curated by eLife

  eLife Assessment

  Abssy et al. carried out a study to test the effects of repetitive peripheral magnetic stimulation (rPMS) on pain perception in an experimental pain model and concluded that the analgesic properties of rPMS could be largely attributed to its auditory component rather than peripheral nerve stimulation per se. While the study presents valuable data on the modulation of pain perception in response to the stimulation paradigms that were tested, several issues in the experimental design and interpretation of results render the evidence incomplete to support their main claims, which should therefore be revised. In that case, these results could be of interest to pain clinicians and researchers.

Reviewed by eLife

Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates

1. Karen A. Lindquist
2. Jennifer M. Mecklenburg
3. Anahit H. Hovhannisyan
4. Shivani B. Ruparel
5. RE-JOIN Consortium Investigators
6. Armen N. Akopian

Reviewed by preLights