Neuroscience

Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

1. Lewis D. Evans
2. Alessio Strano
3. Eleanor Tuck
4. Ashley Campbell
5. James Smith
6. Christy Hung
7. Tiana S. Behr
8. Bernardino Ghetti
9. Benjamin Ryskeldi-Falcon
10. Emre Karakoc
11. Francesco Iorio
12. Alastair Reith
13. Andrew R. Bassett
14. Frederick J. Livesey

Reviewed by Review Commons

Changes in large-scale neural networks under stress are linked to affective reactivity to stress in real life

1. Rayyan Tutunji
2. Martin Krentz
3. Nikos Kogias
4. Lycia de Voogd
5. Florian Krause
6. Eliana Vassena
7. Erno J Hermans

• Curated by eLife

  eLife Assessment

  This important study examines the effects of acute social stress on brain function, focusing on dynamic shifts in large-scale networks such as the salience and default mode networks. It highlights a robust association between stress-induced changes in salience network activation and stress reactivity in daily life, although evidence linking brain function changes following acute stress to real-life stress is incomplete. The findings are significant for stress biology research and could influence future studies on stress responses.

Reviewed by eLife