Neuroscience

Oral Administration of Boldine Reduces Spare Nerve Injury-Induced Neuropathic Pain

1. Jiangping Pan
2. Carlos A. Toro
3. Christine Chow
4. Yorley Duarte
5. Juan C. Sáez
6. Christopher P. Cardozo
7. Wei Zhao

Reviewed by Arcadia Science

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

1. Mofida Abdelmageed
2. Premkumar Palanisamy
3. Victoria Vernail
4. Yuval Silberman
5. Shilpi Paul
6. Anirban Paul

• Curated by eLife

  eLife Assessment

  Abdelmageed et al. demonstrate POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue. Despite potentially exciting and novel findings, many of the authors' claims are provided with incomplete support (e.g. lack of validation of the POLK antibody, characterization of the subcellular compartment, etc).

Reviewed by eLife

Adaptive Integration of Perceptual and Reward Information in an Uncertain World

1. Prashanti Ganesh
2. Radoslaw M Cichy
3. Nicolas W Schuck
4. Carsten Finke
5. Rasmus Bruckner

• Curated by eLife

  eLife Assessment

  This valuable study by Ganesh and colleagues examined how both the value and salience of sensory information can affect economic decision-making. The results provide insights into how different sources of uncertainty found in the real world, including those related to the perception of objects and those related to values associated with objects, can together influence decision-making behavior in systematic ways. The evidence is solid but overlaps with previous studies and could be improved by clarifying novelty and experimental details and considering additional models.

Reviewed by eLife

Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

1. Toshiki Kobayashi
2. Daichi Nozaki

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on how the sensorimotor control system deals with redundancy within our body, based on a novel bimanual task. The evidence supporting the authors' claims is convincing, as demonstrated over four different experiments. The work will be of interest to researchers from the motor control community and related fields, and further investigation into the interpretation of the findings could increase the generalisation of the study to a broader audience.

Reviewed by eLife

Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with spinal cord hemisection

1. Elena Massai
2. Marco Bonizzato
3. Isley De Jesus
4. Roxanne Drainville
5. Marina Martinez

• Curated by eLife

  eLife Assessment

  The contributions of ipsilateral cortical pathways to motor control are yet not fully understood. Here, the authors present important insights into their role in locomotion following unilateral spinal cord injury. Their data provide convincing evidence in rats that stimulation of ipsilateral motor cortex improves the injured side's ability to support weight and leads to improved locomotion, a result that may inspire new treatments for spinal or cerebral injuries.

Reviewed by eLife

Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

1. Max Henry Hills
2. Limei Ma
3. Ai Fang
4. Thelma Chiremba
5. Seth Malloy
6. Allison R Scott
7. Anoja G Perera
8. C Ron Yu

• Curated by eLife

  eLife Assessment

  The manuscript by Hills, et al. presents data that support multiple conclusions regarding the gene expression patterns of cells, especially chemosensory neurons. The evidence is largely solid, with transcriptomic analysis combined and validated by spatially resolved expression in tissue sections, but is incomplete in other ways with some claims not fully supported. This large-scale single-cell transcriptomics dataset is an important resource, alongside a thorough exploration of the molecular features of the different cell types within the mouse vomeronasal organ, including expression of chemosensory receptors.

Reviewed by eLife

Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes

1. Ji Eun Ryu
2. Kyu-Won Shim
3. Hyun Woong Roh
4. Minsung Park
5. Jae-Hyung Lee
6. Eun Young Kim

• Curated by eLife

  eLife Assessment

  This work describes a circadian regulation in the expression of HERP, a regulator of endoplasmic reticulum calcium, in primary astrocytic cultures. This work is important because it highlights the potential importance of circadian rhythms in astrocytes, even though making a direct comparison between these rhythms in vitro and in vivo remains challenging. The technical approaches used in this work (RNA-seq, siRNA, Ca2+ imaging) are a solid support for data interpretation.

Reviewed by eLife

Noisy neuronal populations effectively encode sound localization in the dorsal inferior colliculus of awake mice

1. Juan Carlos Boffi
2. Brice Bathellier
3. Hiroki Asari
4. Robert Prevedel

• Curated by eLife

  eLife Assessment

  The paper reports the important discovery that the mouse dorsal inferior colliculus, an auditory midbrain area, encodes sound location. The evidence supporting the claims is solid, being supported by both optical and electrophysiological recordings. The observations described should be of interest to auditory researchers studying the neural mechanisms of sound localization and the role of noise correlations in population coding.

Reviewed by eLife

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

1. Hyo Jun Kwon
2. Devi Santhosh
3. Zhen Huang

• Curated by eLife

  eLife Assessment

  The study describes a link between beta-amyloid monomers, regulation of microglial activity and assembly of neocortex during development. It brings valuable findings that have theoretical and practical implications in the field of neuronal migration, neuronal ectopia and type II lissencephaly. Unfortunately, the evidence is incomplete and the manuscript would benefit from additional experiments to clarify the relationship between Ric8a and APP and bolster the findings.

Reviewed by eLife

Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice

1. Andres P Varani
2. Caroline Mailhes-Hamon
3. Romain W Sala
4. Sarah Fouda
5. Jimena L Frontera
6. Clément Léna
7. Daniela Popa

• Curated by eLife

  eLife Assessment

  This study provides evidence that cerebellar projections to the thalamus are required for learning and execution of motor skills in the accelerating rotarod task. This important study adds to a growing body of literature on the interactions between the cerebellum, motor cortex, and basal ganglia during motor learning. The data presentation is generally sound, especially the main observations, with some limitations in describing the statistical methods and a lack of support for two segregated cerebello-thalamic pathways, which is incomplete in supporting the overall claim.

Reviewed by eLife