Neuroscience

  1. In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling

    1. Da Guo
    2. Marylka Yoe Uusisaari

    • Curated by eLife

      eLife Assessment

      This is a valuable study, tackling the long-standing issue of the difficulty in imaging the inferior olive and addressing the most relevant questions with a rigorous approach. The technological advance allowed the authors to generate solid experimental evidence with high-quality data. The results are presented clearly and the analyses are rigorous.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. How the layer-dependent ratio of excitatory to inhibitory cells shapes cortical coding in balanced networks

    1. Arezoo Alizadeh
    2. Bernhard Englitz
    3. Fleur Zeldenrust

    • Curated by eLife

      eLife assessment

      The study presents a useful computational analysis of how the ratio between excitatory and inhibitory neural numbers affects coding capacity. The authors show that increasing the proportion of inhibitory neurons (as observed in upper cortical layers compared to the input recipient layer 4) increases the dimensionality of neural activity and improves the encoding of time-varying stimuli. However, the evidence about the role of the inhibitory population in coding is incomplete because numerical results are neither supported by analytical mathematical results nor include controls for changes in firing thresholds or subtypes of inhibitory neurons.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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