Neuroscience

Drift in Individual Behavioral Phenotype as a Strategy for Unpredictable Worlds

1. Ryan Maloney
2. Athena Ye
3. Sam-Keny Saint-Pre
4. Tom Alisch
5. David Zimmerman
6. Nicole Pittoors
7. Benjamin L de Bivort

• Curated by eLife

  eLife Assessment

  Maloney et al. offer an important contribution to understanding the potential ecological mechanisms behind individual behavioral variation. By providing compelling theoretical data and convincing experimental data, the study bridges the gap between individual, apparently stochastic behavior with its evolutionary purpose and consequences. The work further provides a testable and generalizable model framework to explore behavioral drift in other behaviors.

Reviewed by eLife

Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs

1. Himawari Hirai
2. Kohtarou Konno
3. Miwako Yamasaki
4. Masahiko Watanabe
5. Takeshi Sakaba
6. Yuki Hashimotodani

• Curated by eLife

  eLife Assessment

  This fundamental work provides evidence that glutamate and GABA are released from different synaptic vesicles at supramammillary axon terminals onto granule cells of the dentate gyrus. The study uses complementary electrophysiological and anatomical experimental approaches. Together, these provide convincing evidence that the co-release of glutamate and GABA from different vesicles within the same terminal could modulate granule cell firing in a frequency-dependent manner, although thorough elimination of alternative mechanisms would have strengthened the study. The work will be of interest to neuroscientists investigating co-release of neurotransmitters in various synapses in the brain and those interested in subcortical control of hippocampal function.

Reviewed by eLife

Brainstem neurons coordinate the bladder and urethra sphincter for urination

1. Xing Li
2. Xianping Li
3. Jun Li
4. Han Qin
5. Shanshan Liang
6. Jun Li
7. Tingliang Jian
8. Xia Wang
9. Lingxuan Yin
10. Chunhui Yuan
11. Xiang Liao
12. Hongbo Jia
13. Xiaowei Chen
14. Jiwei Yao

• Curated by eLife

  eLife Assessment

  In this important study, Li et al. identify estrogen receptor 1-expressing neurons (ESR1+) in Barrington's nucleus as key regulators coordinating both bladder contraction and the relaxation of the external urethral sphincter. Using appropriate and validated methodologies aligned with the current state of the art, the data are convincing and of generally high quality.

Reviewed by eLife

Circadian modulation of mosquito host-seeking persistence by Pigment-Dispersing Factor impacts daily biting patterns

1. Linhan Dong
2. Richard Hormigo
3. Jord M. Barnett
4. Chloe Greppi
5. Laura B. Duvall

Reviewed by preLights

Microglia attenuate regenerative neurogenesis via sema4ab after spinal cord injury in zebrafish

1. Alberto Docampo-Seara
2. M. Ilyas Cosacak
3. Kim Heilemann
4. Friederike Kessel
5. Ana-Maria Oprişoreanu
6. Markus Westphal
7. Özge Çark
8. Daniela Zöller
9. Josi Arnold
10. Anja Bretschneider
11. Alisa Hnatiuk
12. Nikolay Ninov
13. Catherina G. Becker
14. Thomas Becker

Reviewed by PREreview

Mapping patterns of thought onto brain activity during movie-watching

1. Raven Star Wallace
2. Bronte Mckeown
3. Ian Goodall-Halliwell
4. Louis Chitiz
5. Philippe Forest
6. Theodoros Karapanagiotidis
7. Bridget Mulholland
8. Adam Turnbull
9. Tamara Vanderwal
10. Samyogita Hardikar
11. Tirso RJ Gonzalez Alam
12. Boris C Bernhardt
13. Hao-Ting Wang
14. Will Strawson
15. Michael Milham
16. Ting Xu
17. Daniel S Margulies
18. Giulia L Poerio
19. Elizabeth Jefferies
20. Jeremy I Skipper
21. Jeffrey D Wammes
22. Robert Leech
23. Jonathan Smallwood

• Curated by eLife

  eLife Assessment

  This study presents a valuable methodological advancement in quantifying thoughts over time. A novel multi-dimensional experience-sampling approach is presented, identifying data-driven patterns that the authors use to interrogate fMRI data collected during naturalistic movie-watching. The experimentation is inventive and the analyses carried out and results presented are convincing.

Reviewed by eLife

TYK2 as a novel therapeutic target in Alzheimer’s Disease with TDP-43 inclusions

1. Laura E. König
2. Steve Rodriguez
3. Clemens Hug
4. Shayda Daneshvari
5. Alexander Chung
6. Gary A. Bradshaw
7. Asli Sahin
8. George Zhou
9. Robyn J. Eisert
10. Federica Piccioni
11. Sudeshna Das
12. Marian Kalocsay
13. Artem Sokolov
14. Peter Sorger
15. David E. Root
16. Mark W. Albers

Reviewed by PREreview

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

1. Mengqiao Cui
2. Xiaoyuan Pan
3. Zhijie Fan
4. Shulin Wu
5. Ran Ji
6. Xianlei Wang
7. Xiangxi Kong
8. Zhou Wu
9. Lingzhen Song
10. Weiyi Song
11. Jun-Xia Yang
12. Hongjie Zhang
13. Hongxing Zhang
14. Hai-Lei Ding
15. Jun-Li Cao

• Curated by eLife

  eLife Assessment

  This study investigates the molecular mechanisms underlying chronic pain-related memory impairment by focusing on S1P/S1PR1 signaling in the dentate gyrus (DG) of the hippocampus. Through behavioral tests (Y-maze and Morris water maze) and RNA-seq analysis, the researchers discovered that S1P/S1PR1 signaling is crucial for determining susceptibility to memory impairment, with decreased S1PR1 expression linked to structural plasticity changes and memory deficits. This work has important significance and a convincing level of evidence, thus offering new insights into the mechanisms underlying chronic pain-related memory impairment.

Reviewed by eLife

Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

1. Bhanu Shrestha
2. Jiun Sang
3. Suman Rimal
4. Youngseok Lee

• Curated by eLife

  eLife Assessment

  This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

Reviewed by eLife, preLights

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

1. Josse Poppinga
2. Nolan J Barrett
3. L Niels Cornelisse
4. Matthijs Verhage
5. Jan RT van Weering

• Curated by eLife

  eLife Assessment

  This important study presents a series of results aimed at uncovering the involvement of the endosomal sorting protein SNX4 in neurotransmitter release. While the evidence supporting the conclusions is solid, the molecular mechanisms remain unclear. This paper will be of interest to cell biologists and neurobiologists.

Reviewed by eLife