Neuroscience

Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency

1. Vi Pham
2. Lucas Tricoli
3. Xinying Hong
4. Parith Wongkittichote
5. Carlo Castruccio Castracani
6. Amaliris Guerra
7. Lars Schlotawa
8. Laura A. Adang
9. Amanda Kuhs
10. Margaret M. Cassidy
11. Owen Kane
12. Emily Tsai
13. Maximiliano Presa
14. Cathleen Lutz
15. Stefano B. Rivella
16. Rebecca C. Ahrens-Nicklas

Reviewed by Arcadia Science

Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision making

1. Miguel Barretto García
2. Marcus Grueschow
3. Marius Moisa
4. Rafael Polania
5. Christian C Ruff

• Curated by eLife

  eLife Assessment

  In this important paper, Garcia et al seek to determine whether the superior frontal sulcus (SFS), an area previously implicated in evidence accumulation for perceptual decisions, plays a causal role in perceptual and/or value-based decisions. Through a combination of careful paradigm design, computational modelling, transcranial magnetic stimulation and fMRI analyses, the authors provide convincing evidence that the SFS supports perceptual but not value-based decisions and that its disruption leads to a lowering of decision boundaries.

Reviewed by eLife

Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

1. Ryo Egawa
2. Kota Hiraga
3. Ryosuke Matsui
4. Dai Watanabe
5. Hiroshi Kuba

• Curated by eLife

  eLife Assessment

  This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

1. Naidi Sun
2. Yu-Yo Sun
3. Rui Cao
4. Hong-Ru Chen
5. Yiming Wang
6. Elizabeth Fugate
7. Marchelle R Smucker
8. Yi-Min Kuo
9. P Ellen Grant
10. Diana M Lindquist
11. Chia-Yi Kuan
12. Song Hu

• Curated by eLife

  eLife Assessment

  This is an important study that utilized in vivo optical measurements of the cortical metabolic rate of O2 and blood flow, as well as measurements in isolated mitochondria to assess the uncoupling of the oxidative phosphorylation due to hypoxia-ischemia injury of the neonatal brain, and effects of the hypothermia treatment. The combination of state-of-the-art optical measurements, mitochondrial assays, and the use of various control experiments provides convincing evidence for the derived conclusions. This work will be of interest to those in the mitochrondrial metabolomics, brain injury and hypoxia fields.

Reviewed by eLife

Phase-specific premotor inhibition modulates leech rhythmic motor output

1. Martina Radice
2. Agustín Sanchez Merlinsky
3. Federico Yulita
4. Lidia Szczupak

• Curated by eLife

  eLife Assessment

  The medicinal leech preparation is an amenable system in which to understand the neural basis of locomotion. Here a previously identified non-spiking neuron was studied in leech and found to alter the mean firing frequency of a crawl-related motoneuron, which fires during the contraction phase of crawling. The findings are valuable and the experiments were diligently done and considered solid. The results lay a foundation for additional studies in this system.

Reviewed by eLife

The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats

1. Francesca S Wong
2. A Simon Killcross
3. R Fred Westbrook
4. Nathan M Holmes

• Curated by eLife

  eLife Assessment

  This important Research Advance builds on the authors' previous work delineating the roles of the rodent perirhinal cortex and the basolateral amygdala in first- and second-order learning. The convincing results show that serial exposure of non-motivationally relevant stimuli influences how those stimuli are encoded within the perirhinal cortex and basolateral amygdala when paired with a shock. This manuscript will be interesting for researchers in cognitive and behavioral neuroscience.

Reviewed by eLife

How Occam’s razor guides human decision-making

1. Eugenio Piasini
2. Shuze Liu
3. Pratik Chaudhari
4. Vijay Balasubramanian
5. Joshua I Gold

• Curated by eLife

  eLife Assessment

  This study presents an important new approach to quantifying parsimony preferences in human inference. The work provides convincing evidence that humans are sensitive to specific formalizations of parsimony, such as the dimensionality of perceptual shapes. The work is considered timely, well-written, and technically sophisticated, effectively bridging concepts from statistical inference and human decision-making.

Reviewed by eLife

EEG decodability of facial expressions and their stereoscopic depth cues in immersive virtual reality

1. Felix Klotzsche
2. Ammara Nasim
3. Simon M Hofmann
4. Arno Villringer
5. Vadim Nikulin
6. Werner Sommer
7. Michael Gaebler

• Curated by eLife

  eLife Assessment

  This valuable study successfully decoded visual representations of facial expressions and stereoscopic depth information from electroencephalogram (EEG) signals recorded in an immersive virtual reality (VR) environment. The evidence is solid in demonstrating the technical feasibility of integrating state-of-the-art EEG decoding and VR with eye tracking. This work will interest neuroscience researchers, as well as engineers developing brain-machine interfaces and/or virtual reality displays.

Reviewed by eLife

Robust and replicable effects of ageing on resting state brain electrophysiology measured with MEG

1. Andrew J Quinn
2. Jemma Pitt
3. Oliver Kohl
4. Chetan Gohil
5. Mats WJ van Es
6. Anna C Nobre
7. Mark W Woolrich

• Curated by eLife

  eLife Assessment

  The authors ask whether a simple whole-head spectral power analysis of human magnetoencephalography data recorded at rest in a large cohort of adults shows robust effects of age, and their results provide compelling evidence that it does. The relative simplicity of the analysis is a major strength of the paper, and the authors are careful to control for many different confounds - although perhaps highly correlated factors like brain anatomy still pose a slight issue. The paper provides a valuable power analysis framework that should inform researchers across the broader neuroimaging community

Reviewed by eLife

Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

1. Yue Guzhang
2. T Florian Jaeger
3. Martina Poletti

• Curated by eLife

  eLife Assessment

  This study explores how exogenous attention operates at the finest spatial scale of vision, within the foveola - a topic that has not been previously explored. The question is important for understanding how attention shapes perception, and how it differs between the periphery and the central regions of highest visual acuity. The evidence is compelling, as shown by carefully designed experiments with state-of-the-art eye tracking to monitor attended locations just a few tens of minutes of arc away from the fixation target, but additional clarification regarding analyses and implications for vision and oculomotor control would broaden the impact of the study.

Reviewed by eLife