1. Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    This article has 8 authors:
    1. Louis Richevaux
    2. Dongkyun Lim
    3. Mérie Nassar
    4. Léa Dias Rodrigues
    5. Constanze Mauthe
    6. Ivan Cohen
    7. Nathalie Sol-Foulon
    8. Desdemona Fricker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study combines anatomical tracing and slice physiology to examine how anterior thalamic and retrosplenial inputs converge in the presubiculum, a key region in the navigation circuit. The authors show that near-simultaneous co-activation of retrosplenial and thalamic inputs drives supra-linear presubiculum responses, revealing a potential cellular mechanism for anchoring the brain's head direction system to external visual landmarks. Their thorough experimental approach and analyses provide convincing evidence for the cellular basis of how the brain's internal compass may be anchored to the external world, laying the groundwork for future experimental testing in vivo.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  2. Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    This article has 10 authors:
    1. Kasturi Biswas
    2. Caroline Moore
    3. Hannah Rogers
    4. Khursheed A Wani
    5. Read Pukkila-Worley
    6. Daniel P Higgins
    7. Amy K Walker
    8. Gregory P Mullen
    9. James B Rand
    10. Michael M Francis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study advances our understanding of how organisms respond to chronic oxidative stress. Using the nematode C. elegans, the authors identified key neuronal signaling molecules and their receptors that are required for stress signaling and survival. The evidence supporting the conclusions is solid, with rigorous genetics, stress response analysis, and transcriptional profiling. This research will be of broad interest to neuroscientists and researchers working in the field of oxidative stress regulation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing

    This article has 3 authors:
    1. Ellen Lesser
    2. Anthony Moussa
    3. John C Tuthill
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work by Lesser et al provides a first and comprehensive description of Drosophila wing proprioceptors at an EM resolution. By linking peripheral neurons with information on their morphology and connectivity in the central nervous system, the authors provide new hypotheses and tools to study proprioceptive motor control of the wing in the fruit fly. The evidence and techniques supporting this work are solid, and this resource will contribute to connectome-based modeling of fly behavior.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Comprehensive Neural Representations of Naturalistic Stimuli through Multimodal Deep Learning

    This article has 5 authors:
    1. Mingxue Fu
    2. Guoqiu Chen
    3. Yijie Zhang
    4. Mingzhe Zhang
    5. Yin Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable application of a video-text alignment deep neural network model to improve neural encoding of naturalistic stimuli in fMRI. The authors found that models based on multimodal and dynamic embedding features of audiovisual movies predicted brain responses better than models based on unimodal or static features. The evidence supporting the claims is generally solid, with clear benchmarking against baseline models. The work will be of interest to researchers in cognitive neuroscience and AI-based brain modeling.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats

    This article has 4 authors:
    1. Francesca S Wong
    2. A Simon Killcross
    3. R Fred Westbrook
    4. Nathan M Holmes
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important Research Advance builds on the authors' previous work delineating the roles of the rodent perirhinal cortex and the basolateral amygdala in first- and second-order learning. The convincing results show that serial exposure of non-motivationally relevant stimuli influences how those stimuli are encoded within the perirhinal cortex and basolateral amygdala when paired with a shock. This manuscript will be interesting for researchers in cognitive and behavioral neuroscience.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans

    This article has 2 authors:
    1. Paola V. Figueroa-Delgado
    2. Shaul Yogev

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    This article has 7 authors:
    1. Sofia Lövestam
    2. Jane L Wagstaff
    3. Taxiarchis Katsinelos
    4. Jenny Shi
    5. Stefan MV Freund
    6. Michel Goedert
    7. Sjors HW Scheres
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This fundamental study will allow in vitro mechanistic investigations. The presented evidence is convincing. This manuscript will be of interest to all scientists in the amyloid formation field.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle

    This article has 2 authors:
    1. Oksana Cohen
    2. Yoram Ben-Shaul
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work substantially advances our understanding of how accessory olfactory bulb neurons respond to social odor cues across the estrous cycle, showing that responses vary with the strain and sex of the odor source but display no consistent differences between estrous and non-estrous states. It employs a unique electrophysiology preparation that activates the vomeronasal organ pump via electric stimulation, enabling precise recordings of accessory olfactory bulb cell responses to different chemosignals in anesthetized mice. Overall, the study presents convincing findings on the stability and variability of accessory olfactory bulb response patterns, indicating that while accessory olfactory bulb detects social signals, it does not appear to interpret them based on reproductive state. This work will be of interest to those studying olfaction, social behavior, reproductive cycles, and systems neuroscience more broadly.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. High Cognitive Violation of Expectations is Compromised in Cerebellar Ataxia

    This article has 3 authors:
    1. Leonardo A Daniel
    2. Eli Vakil
    3. William Saban
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable investigation provides new and solid evidence for a specific cognitive deficit in cerebellar degeneration patients. The authors use three tasks that modulate complexity and violations of cognitive expectations. They show specific slowing of reaction times in the presence of violations but not with task complexity. While some alternative interpretations of the results are possible and are discussed, the work provides a new, invaluable data point in describing the cognitive contribution of cerebellar processing.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  10. Age and Learning Shapes Sound Representations in Auditory Cortex During Adolescence

    This article has 6 authors:
    1. Benedikt Praegel
    2. Feng Chen
    3. Adria Dym
    4. Amichai Lavi-Rudel
    5. Shaul Druckmann
    6. Adi Mizrahi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study suggests that adolescent mice exhibit less accuracy than adult mice in a sound discrimination task when the sound frequencies are very similar. The evidence supporting this observation is solid and suggests that it arises from cognitive control differences between adolescent and adult mice. The adolescent period is largely understudied, despite its contribution to shaping the adult brain, which makes this study interesting for a broad range of neuroscientists.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
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