1. Virtual Brain Inference (VBI): A flexible and integrative toolkit for efficient probabilistic inference on virtual brain models

    This article has 6 authors:
    1. Abolfazl Ziaeemehr
    2. Marmaduke Woodman
    3. Lia Domide
    4. Spase Petkoski
    5. Viktor Jirsa
    6. Meysam Hashemi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper presents a valuable software package, named "Virtual Brain Inference" (VBI), that enables faster and more efficient inference of parameters in dynamical system models of whole-brain activity, grounded in artificial network networks for Bayesian statistical inference. The authors have provided convincing evidence, across several case studies, for the utility and validity of the methods using simulated data from several commonly used models, but more thorough benchmarking could be used to demonstrate the practical utility of the toolkit. This work will be of interest to computational neuroscientists interested in modelling large-scale brain dynamics.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons During Novel Exploration

    This article has 4 authors:
    1. En-Li Chen
    2. Tsai-Wen Chen
    3. Eric R Schreiter
    4. Bei-Jung Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors use a cutting-edge method to perform voltage imaging of CA1 pyramidal cells in head-fixed mice running on a track while local field potentials (LFPs) were recorded in the contralateral hemisphere. The authors provide solid evidence of synchronous ensembles of CA1 pyramidal neurons that are associated with contralaterally recorded theta rhythms but not with contralaterally recorded sharp wave-ripples during exploration of a novel environment. The paper will be of interest to scientists who are interested in hippocampal neuronal coding of novel environments, particularly those with experimental questions that can benefit from this cutting-edge imaging technique.

    Reviewed by eLife

    This article has 21 evaluationsAppears in 1 listLatest version Latest activity
  3. Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

    This article has 11 authors:
    1. Congcong Ma
    2. Zhaoxing Jia
    3. Tianxiang Jiang
    4. Qian Cai
    5. Jinding Yang
    6. Lin Gan
    7. Kecheng Qian
    8. Zixin Pan
    9. Qinyu Ye
    10. Mengyuan Dai
    11. Xianming Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper reports a valuable discovery that specific-mode electroacupuncture (EA) transiently opens the blood-brain barrier (BBB) in rats. The evidence is solid but lacks functional validation of BBB permeability changes. The work will be of interest to medical scientists working in the field of electroacupuncture and drug delivery.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Neural signatures of motor memories emerge in neural network models

    This article has 3 authors:
    1. Joanna C Chang
    2. Claudia Clopath
    3. Juan A Gallego
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable computational findings on the neural basis of learning new motor memories without interfering with previously learned behaviours using recurrent neural networks. The evidence supporting the claims of the authors is solid, but it would benefit from stronger and clearer links with experimental findings. This work will be of interest to computational and experimental neuroscientists working in motor learning.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

    This article has 12 authors:
    1. Elise J Meijer
    2. Marissa Mueller
    3. Lukas B Krone
    4. Tomoko Yamagata
    5. Anna Hoerder-Suabedissen
    6. Sian Wilcox
    7. Hannah Alfonsa
    8. Atreyi Chakrabarty
    9. Luiz Guidi
    10. Peter L Oliver
    11. Vladyslav V Vyazovskiy
    12. Zoltán Molnár
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study offers a valuable contribution to our understanding of the role of layer 6b cortical neurons in sleep-wake regulation, providing new insight into how this understudied neural population may regulate cortical arousal via orexin signaling. The evidence supporting these findings is solid, although somewhat constrained by limitations in the specificity of the genetic targeting strategy. Nonetheless, the work introduces new avenues for uncovering how the classical wake-promoting peptide, orexin, exerts its effects on the cortex.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Resolving synaptic events using subsynaptically targeted GCaMP8 variants

    This article has 7 authors:
    1. Jiawen Chen
    2. Junhao Lin
    3. Kaikai He
    4. Luyi Wang
    5. Yifu Han
    6. Chengjie Qiu
    7. Dion Dickman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important study, the authors engineered and characterised novel genetically encoded calcium indicators (GECIs) and an analytical tool (CaFire) capable of reporting and quantifying various sub-synaptic events, including miniature synaptic events, with a speed and sensitivity approaching that of intracellular electrophysiological recordings. While the evidence supporting the improvements in the speed and accuracy of these tools is convincing, including additional information about key imaging parameters, the Bar8f experiments, and CaFire would strengthen the study. This work will be of interest to neurobiologists studying synaptic calcium dynamics in various model systems.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Widespread cortical representations of innate behaviors in the mouse

    This article has 3 authors:
    1. Nicholas J Michelson
    2. Pankaj K Gupta
    3. Timothy H Murphy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work shows that subcortically-generated behaviors, like grooming, can have widespread representations in cortical activity. While the evidence is solid, additional analyses are necessary to strengthen the claims associated with outsized cortical representations of grooming onsets, as well as to address atypical grooming events. This work will be of interest to neuroscientists interested in how subcortically-generated behaviors are represented across the cortex.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    This article has 10 authors:
    1. Guylaine Hoffner
    2. Pablo Castro
    3. Lynn Uhrig
    4. Camilo M Signorelli
    5. Morgan Dupont
    6. Jordy Tasserie
    7. Alain Destexhe
    8. Rodrigo Cofre
    9. Jacobo Sitt
    10. Bechir Jarraya
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study applies transcranial direct current stimulation (tCDS) to the prefrontal cortex of non-human primates during two states: (1) propofol-induced unconsciousness; and (2) wakeful performance of a fixation task. The analysis offers incomplete evidence to indicate that the effect of tDCS on brain dynamics, as recorded with functional magnetic resonance imaging, is contingent on the state of consciousness during which the stimulation is applied. The findings will be of interest to researchers interested in brain stimulation and consciousness.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

    This article has 12 authors:
    1. Linda H Kim
    2. Adam P Lognon
    3. Sandeep Sharma
    4. Michelle A Tran
    5. Cecilia Badenhorst
    6. Taylor Chomiak
    7. Stephanie Tam
    8. Claire McPherson
    9. Todd E Stang
    10. Shane EA Eaton
    11. Zelma HT Kiss
    12. Patrick J Whelan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reveals the pro-locomotor effects of activating a deep brain region containing diverse range of neurons in both healthy and Parkinson's disease mouse models. While the findings are solid, mechanistic insights remain limited due to the small sample size. This research is relevant to motor control researchers and offers clinical perspectives.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  10. Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    This article has 10 authors:
    1. Tom Bonnifet
    2. Sandra Sinnassamy
    3. Olivia Massiani-Beaudoin
    4. Philippe Mailly
    5. Héloïse Monnet
    6. Damarys Loew
    7. Berangère Lombard
    8. Nicolas Servant
    9. Rajiv L Joshi
    10. Julia Fuchs
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Bonnifet et al. present data on the expression and interacting partners of the transposable element L1 in the mammalian brain. The work includes important findings addressing the potential role of L1 in aging and neurodegenerative disease. The reviewers conclude that several aspects of the study are well done and most evidence is solid, with a noted concern related to the RNA-seq analysis.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
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