1. Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    This article has 10 authors:
    1. Tom Bonnifet
    2. Sandra Sinnassamy
    3. Olivia Massiani-Beaudoin
    4. Philippe Mailly
    5. Héloïse Monnet
    6. Damarys Loew
    7. Berangère Lombard
    8. Nicolas Servant
    9. Rajiv L Joshi
    10. Julia Fuchs
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Bonnifet et al. present data on the expression and interacting partners of the transposable element L1 in the mammalian brain. The work includes important findings addressing the potential role of L1 in aging and neurodegenerative disease. The reviewers conclude that several aspects of the study are well done. However, the experimental evidence presented supporting the L1 increase with aging is not fully conclusive and this finding remains incomplete in its current form.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques

    This article has 7 authors:
    1. Amber M Howell
    2. Shaun Warrington
    3. Clara Fonteneau
    4. Youngsun T Cho
    5. Stamatios N Sotiropoulos
    6. John D Murray
    7. Alan Anticevic
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study describes patterns of anatomical connectivity between the cortex and the thalamus using magnetic resonance imaging data in humans and non-human primates. The measures are related to numerous other modalities to develop a robust understanding of the organisation of the system. The authors provide convincing evidence that there is a difference between sensory and association cortices in terms of their connectivity with the thalamus, which may have downstream effects on brain function. This work will be of interest to neuroscientists interested in the organization and dynamics of cortico-thalamic circuits.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

    This article has 6 authors:
    1. Peter J Murphy
    2. Juliette E McGregor
    3. Zhengyang Xu
    4. Qiang Yang
    5. William Merigan
    6. David R Williams
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper shows that it is possible to optogenetically activate single retinal ganglion cells in vivo in monkeys. This is an important step towards towards causal tests of the role of specific ganglion cell types in visual perception. The paper presents convincing evidence for the promise of the approach but further work will be needed to full explore its limitations and specificity.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Inhibitory circuits generate rhythms for leg movements during Drosophila grooming

    This article has 3 authors:
    1. Durafshan Sakeena Syed
    2. Primoz Ravbar
    3. Julie H Simpson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Using a combination of connectomics, optogenetics, behavioral analysis, and modeling, this study provides important findings on the role of two populations of inhibitory neurons in the generation of leg grooming movements in Drosophila. The data as presented provide incomplete evidence that the identified neuronal populations contribute to the alternation of flexion and extension by inhibiting specific sets of motor neurons while disinhibiting their counterparts. While the manuscript provides comprehensive details about the 13A/B neuronal populations involved in grooming control, updates on statistics, and explicit mentioning of experimental/modeling caveats would strengthen the study. The work will interest neuroscientists, and particularly those working on motor control.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    This article has 5 authors:
    1. Javier Emperador-Melero
    2. Steven J Del Signore
    3. Kevin M De León González
    4. Pascal S Kaeser
    5. Avital A Rodal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila and rodent model systems, to define the role of activity and active zone structure on the organization of the peri-active zone. While the findings are primarily negative, they are carefully executed and contribute to the field by refining existing models of presynaptic organization.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Dynamic fMRI networks of emotion

    This article has 4 authors:
    1. Niels Janssen
    2. Uriel KA Elvira
    3. Joost Janssen
    4. Theo GM van Erp
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable information on the neurodynamics of emotional processing while participants were watching movie clips. The methods and results were solid in deciphering the temporal-spatial dynamics of emotional processing. This work will be of interest to affective neuroscientists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Gamma Synchrony Mediates Figure-Ground Perception

    This article has 4 authors:
    1. Maryam Karimian
    2. Mark J Roberts
    3. Peter De Weerd
    4. Mario Senden
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Karimian et al. present a valuable new model to explain how gamma-band synchrony (30-80 Hz) can support human visual feature binding by selectively grouping image elements, countering recent criticisms that the stimulus dependence of gamma oscillations limits their functional role. Grounded in the theory of weakly coupled oscillators and informed by primate electrophysiology, the model captures behavioural patterns observed in human psychophysics, offering support for the potential role of synchrony-based mechanisms, but incomplete evidence for a specific role of gamma oscillations. This work could be strengthened by more direct evidence for the proposed mechanism, and expanding beyond figure-only model inputs with limited ecological validity.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

    This article has 6 authors:
    1. Jenifer C Kaldun
    2. Emanuele Calia
    3. Ganesh Chinmai Bangalore Mukunda
    4. Cornelia Fritsch
    5. Nikita Komarov
    6. Simon G Sprecher
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors design and implement an elegant strategy to delete genomic sequences encoding the dopamine receptor dop1R2 from specific subsets of mushroom body neurons (ab, a'b' and gamma) and show that while none of these manipulations affect short term appetitive or aversive memory, loss of dop1R2 from ab or a'b' block the ability of flies to display measurable forms of longer forms of memory. These findings are important in confirming and extending prior observations, and well supported by convincing evidence that build on precise techniques for genetic perturbation.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects – results from a pharmacological fMRI study

    This article has 3 authors:
    1. Janne I Nold
    2. Tahmine Fadai
    3. Christian Büchel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, Nold et al. examined exercise-induced pain modulation in a pharmacological within-subject fMRI study using the opioid-antagonist naloxone and different levels of aerobic exercise intensity and pain. This investigation provides solid evidence to show that the intensity of exercise does not seem to impact the hypoalgesic effect. Moreover, exploratory analysis identified that fitness level and sex may potentially play a role in exercise-induced hypoalgesia, and that further confirmatory studies are required in order to verify these findings.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Midbrain somatostatin-expressing cells control pain-suppression during defensive states

    This article has 15 authors:
    1. Nanci Winke
    2. Frank Aby
    3. Daniel Jercog
    4. Thomas Bienvenu
    5. Coline Riffault
    6. Rabia Bouali-Benazzouz
    7. Juliette Viellard
    8. Delphine Girard
    9. Zoé Grivet
    10. Marc Landry
    11. Laia Castell
    12. Emmanuel Valjent
    13. Stephane Valerio
    14. Pascal Fossat
    15. Cyril Herry
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study is a timely and important contribution to our knowledge of the circuit mechanisms of fear analgesia. The novel cue-induced analgesia paradigm allowed a compelling identification of a brainstem circuit element, i.e., somatostatin-expressing neurons within the ventrolateral periaqueductal grey that project to the rostroventral medulla, in mediating fear analgesia. The vlPAG is a known region of pain modulation, and this study adds key insight to the circuit involved in fear-associated analgesia. This work will be of interest to systems and behavioral neuroscientists, especially those interested in emotional behavior, pain, and/or brainstem function.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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