Neuroscience

Grid cells encode reward distance during path integration in cue-rich environments

1. Satoshi Kuroki
2. Sébastien Royer

Reviewed by PREreview

Reduced melanocortin tone mediates increased feeding during pregnancy in mice

1. Ingrid Camila Possa-Paranhos
2. Kerem Catalbas
3. Samuel Congdon
4. Tanya Pattnaik
5. Christina Nelson
6. Dajin Cho
7. Patrick Sweeney

Reviewed by PREreview

Nociceptors use multiple neurotransmitters to drive pain

1. Donald Iain MacDonald
2. Rakshita Balaji
3. Alexander T. Chesler

Reviewed by PREreview

Dietary restriction promotes neuronal resilience via ADIOL

1. Ana Guijarro-Hernández
2. Shinja Yoo
3. George A. Lemieux
4. Sena Komatsu
5. Abdullah Q. Latiff
6. Rishika R. Patil
7. Kaveh Ashrafi

Reviewed by PREreview

The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons

1. Briana Machen
2. Sierra N. Miller
3. Al Xin
4. Carine Lampert
5. Lauren Assaf
6. Julia Tucker
7. Sarah Herrell
8. Francisco Pereira
9. Gabriel Loewinger
10. Sofia Beas

Reviewed by PREreview

The representation of facial emotion expands from sensory to prefrontal cortex with development

1. Xiaoxu Fan
2. Abhishek Tripathi
3. Kelly R Bijanki

• Curated by eLife

  **eLife Assessment
  **
  This study examines an important question regarding the developmental trajectory of neural mechanisms supporting facial expression processing. Leveraging a rare intracranial EEG (iEEG) dataset including both children and adults, the authors reported that facial expression recognition mainly engaged the posterior superior temporal cortex (pSTC) among children, while both pSTC and the prefrontal cortex were engaged among adults. In terms of strength of evidence, the solid methods, data and analyses broadly support the claims with minor weaknesses.

Reviewed by eLife

A Forebrain Hub for Cautious Actions via the Midbrain

1. Ji Zhou
2. Muhammad S Sajid
3. Sebastian Hormigo
4. Manuel A Castro-Alamancos

• Curated by eLife

  eLife Assessment

  This valuable study uses fiber photometry, implantable lenses, and optogenetics, to show that a subset of subthalamic nucleus neurons are active during movement, and that active but not passive avoidance depends in part on STN projections to substantia nigra. The strength of the evidence for these claims is solid, whereas evidence supporting the claims that STN is involved in cautious responding is unclear as presented. This paper may be of interest to basic and applied behavioural neuroscientists working on movement or avoidance.

Reviewed by eLife

A three-dimensional immunofluorescence atlas of the brain of the hackled-orb weaver spider, Uloborus diversus

1. Gregory Artiushin
2. Abel Corver
3. Andrew Gordus

• Curated by eLife

  eLife Assessment

  This valuable study provides a 3D standardised anatomical atlas of the brain of an orb-weaving spider. The authors describe the brain's shape and its inner compartments-the neuropils-and add information on the distribution of a number of neuroactive substances such as neurotransmitters and neuropeptides. Through the use of histological and microscopy methods the authors provide a more complete view of an arachnid brain than previous studies and also presents convincing evidence about the organisation and homology of brain regions. The work will serve as a reference for future studies on spider brains and will enables comparisons of brain regions with insects so that the evolution of these structures can be inferred across arthropods.

Reviewed by eLife

Emergence of Functional Heart-Brain Circuits in a Vertebrate

1. Luis Hernandez-Nunez
2. Joana Avrami
3. Sky Shi
4. Areni Markarian
5. Annette Kim
6. Jonathan Boulanger-Weill
7. Virginia Rutten
8. Arman Zarghani-Shiraz
9. Misha B Ahrens
10. Florian Engert
11. Mark C Fishman

• Curated by eLife

  eLife Assessment

  In this important manuscript, the authors establish a vertebrate model for studying the development of circuits that control heart rate. This contribution uses a combination of experimental techniques to provide compelling information for scientists looking to understand how heart rate regulation emerges during development.

Reviewed by eLife

Intersection of transient cell states with stable cell types in hippocampus

1. Jack A Olmstead
2. Lauren E King
3. Brenda L Bloodgood

• Curated by eLife

  eLife Assessment

  This important study provides a detailed analysis of the transcriptional landscape of the mouse hippocampus in the context of various physiological states. The main conclusions have solid support: that most transcriptional targets are generally stable, with notable exceptions in the dentate gyrus and with regard to circadian changes. There are some weaknesses and it would improve the manuscript to address them.

Reviewed by eLife