Neuroscience

The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

1. Lydia Gruber
2. Rafael Cantera
3. Markus William Pleijzier
4. Martin Niebergall
5. Michael Steinert
6. Thomas Pertsch
7. Bill S Hansson
8. Jürgen Rybak

• Curated by eLife

  eLife Assessment

  This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the field. The methodology is solid, and with the caveat that here was a technical need to group all local interneurons, centrifugal neurons and multiglomerular projection neurons into one category ("multiglomerular neurons"), this work reveals some very interesting potential differences in circuit architecture associated with glomerular tuning breadth.

Reviewed by eLife, preLights

Intrinsic Resistance of the Hippocampal CA2 Subfield to Neuroinflammation After Status Epilepticus

1. Bruno Ponciano Da silva
2. Edna Cristina Santos Franco
3. Silene Maria Araújo de Lima

Reviewed by PREreview

Passive muscle forces in Drosophila are large but insufficient to support a fly’s weight

1. Ninghan Wang
2. Helene Babski
3. Jonathan Elliot Perdomo
4. Sarah Beth McMahan
5. Arun Ramakrishnan
6. Tirthabir Biswas
7. Vikas Bhandawat

• Curated by eLife

  eLife Assessment

  This valuable study introduces a novel experimental and modeling framework to quantify passive joint torques in Drosophila, revealing that passive forces are insufficient to support body weight, contrary to prior assumptions based on larger insects. The approach is technically impressive, combining genetic silencing, kinematic tracking, and biomechanical modeling. However, the strength of evidence is incomplete, limited by concerns about the specificity of the genetic tools, simplifications in the mechanical model, and limited functional interpretation.

Reviewed by eLife

A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex

1. Cecilia Hes
2. Abigail J Tomlinson
3. Lieke Michielsen
4. Hunter J Murdoch
5. Fatemeh Soltani
6. Maia V Kokoeva
7. Paul V Sabatini

• Curated by eLife

  eLife Assessment

  This manuscript applies state-of-the-art techniques to define the cellular composition of the dorsal vagal complex in two rodent species (mice and rats). The result is a fundamental resource that substantially advances our understanding of the dorsal vagal complex's role in the regulation of feeding and metabolism while also highlighting key differences between species. The analyses of single-cell profiling experiments in the manuscript provide compelling insight into the cellular architecture of the dorsal vagal complex, with potential implications for obesity therapeutics.

Reviewed by eLife

Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection

1. Kenza Amroune
2. Lorenzo Fontolan
3. Agnès Baude
4. David Robbe
5. Ingrid Bureau

• Curated by eLife

  eLife Assessment

  This revised manuscript provides fundamental findings on how the mouse barrel cortex connects to the dorsolateral striatum, uncovering that inputs from discrete whisker cortical columns are convergent and SPN-specific, but topographically organized at the population level. The evidence supporting this claim is compelling, demonstrating that SPNs uniquely integrate sparse input from variable stretches across the barrel cortex. The study would be of interest to basal ganglia and sensory-motor integration researchers.

Reviewed by eLife

Unsupervised pipeline for the identification of cortical excitatory and inhibitory neurons in high-density multielectrode arrays with ground-truth validation

1. Eloise Giraud
2. Michael Lynn
3. Philippe Vincent-Lamarre
4. Jean-Claude Beique
5. Jean-Philippe Thivierge

• Curated by eLife

  eLife Assessment

  In this manuscript, the authors describe a software package for automatic differentiation of action potentials generated by excitatory and inhibitory neurons, acquired using high-density microelectrode arrays. The work is valuable as it offers a tool with the potential to automatically identify these neuron types in vitro. It is solid, as it provides a tool to identify putative excitatory and inhibitory neurons on high-density electrode arrays, which can be used in conjunction with other existing spike sorting pipelines.

Reviewed by eLife

Unveiling distinct neuroimmune responses in mouse models of cervical spinal cord injury: Hemisection versus hemicontusion

1. Wei Chen
2. Lucille Adam
3. Pauline Michel-Flutot
4. Arnaud Mansart
5. Stéphane Vinit
6. Isabelle Vivodtzev

Reviewed by Arcadia Science

Separable global and local beta burst dynamics in motor cortex of primates

1. Preeya Khanna
2. Behraz Farrokhi
3. Hoseok Choi
4. Sandon Griffin
5. Ian Heimbuch
6. Lisa Novik
7. Katherina Thiesen
8. John Morrison
9. Robert J Morecraft
10. Karunesh Ganguly

• Curated by eLife

  eLife Assessment

  This important study investigates changes in oscillatory activity across cortical and subcortical areas during stroke recovery in a nonhuman primate model. The authors distinguish between global and local oscillatory bursts, providing solid evidence that these two types of bursts correlate with distinct aspects of movement; additionally, they show that the likelihood of these bursts occurring follows opposing trends during recovery. The study could be further improved by accounting for inter-individual differences and by some technical improvements, such as employing more robust burst detection methods and more stringent analyses.

Reviewed by eLife

An evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuits

1. Yang Shen
2. Arkarup Banerjee
3. Dinu F Albeanu
4. Saket Navlakha

• Curated by eLife

  eLife Assessment

  This is a valuable computational study of odor responses in the early olfactory system of insects and vertebrates. The study addresses the question of how information about odor concentration is encoded by second-order neurons in the invertebrate and vertebrate olfactory system; it offers insights into the transformation of neural signals from receptors to second-order neurons. While reanalysis of published data presents solid evidence supporting compression of concentration information, incomplete analysis is provided to resolve how this observation could be reconciled with the need to preserve information about changes in stimulus intensity. This work will be of interest to neuroscientists studying sensory processing broadly and olfaction specifically.

Reviewed by eLife

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

1. Abdulkadir Ozkan
2. Hari K Padmanabhan
3. Seth L Shipman
4. Eiman Azim
5. Priyanka Kumar
6. Cameron Sadegh
7. A Nazli Basak
8. Jeffrey D Macklis

• Curated by eLife

  eLife Assessment

  This study presents fundamental new findings introducing a new approach for the reprogramming of brain glial cells to corticospinal neurons. The data is highly compelling, with multiple lines of evidence demonstrating the success of this new assay. These exciting findings set the stage for future studies of the potential of these reprogrammed cells to form functional connections in vivo and their utility in clinical conditions where corticospinal neurons are compromised.

Reviewed by eLife