1. An Intranet of Things approach for adaptable control of behavioral and navigation-based experiments

    This article has 8 authors:
    1. John C Bowler
    2. George Zakka
    3. Hyun Choong Yong
    4. Wenke Li
    5. Bovey Rao
    6. Zhenrui Liao
    7. James B Priestley
    8. Attila Losonczy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Bowler et al. present a software/hardware system for behavioral control of navigation-based virtual reality experiments, particularly suited for pairing with 2-photon imaging but applicable to a variety of techniques. This system represents a valuable contribution to the field of behavioral and systems neuroscience, as it provides a standardized, easy to implement, and flexible system that could be adopted across multiple laboratories. The authors provide compelling evidence of the functionality of their system by reporting benchmark tests and demonstrating hippocampal activity patterns consistent with standards in the field. This work will be of interest to systems neuroscientists looking to integrate flexible head-fixed behavioral control with neural data acquisition.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Glia control experience-dependent plasticity in an olfactory critical period

    This article has 9 authors:
    1. Hans C Leier
    2. Alexander J Foden
    3. Darren A Jindal
    4. Abigail J Wilkov
    5. Paola Van der Linden Costello
    6. Pamela J Vanderzalm
    7. Jaeda Coutinho-Budd
    8. Masashi Tabuchi
    9. Heather T Broihier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Periods in which experience regulates early plasticity in sensory circuits are well established, but the mechanisms that control these critical periods are poorly understood. In this important study, the authors examine early-life critical periods that regulate the Drosophila antennal lobe and show that constant odor exposure markedly reduces the volume, synapse number, and function of a specific glomerulus. The authors offer compelling evidence that these changes are mediated by the invasion of ensheathing glia into the glomerulus where they phagocytose connections via a mechanism involving the engulfment receptor Draper.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Auditory cortex anatomy reflects multilingual phonological experience

    This article has 8 authors:
    1. Olga Kepinska
    2. Josue Dalboni da Rocha
    3. Carola Tuerk
    4. Alexis Hervais-Adelman
    5. Florence Bouhali
    6. David W Green
    7. Cathy J Price
    8. Narly Golestani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This report details convincing evidence that experience with multilingualism in general, and with larger phonological inventories specifically, is related to differences in the structure of the transverse temporal gyri. The project is notable for using a relatively large sample, and confirming the primary finding in a second sample. The important findings strongly point to experience-dependent plasticity related to language experience as a driver of neuroanatomy of the auditory cortex.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Precision-based causal inference modulates audiovisual temporal recalibration

    This article has 4 authors:
    1. Luhe Li
    2. Fangfang Hong
    3. Stephanie Badde
    4. Michael S Landy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, Li et al., set out to understand the mechanisms of audiovisual temporal recalibration - the brain's ability to adjust to the latency differences that emerge due to different (distance-dependent) transduction latencies of auditory and visual signals - through psychophysical measurements and modeling. The analysis and specification of a formal model for this process provide convincing evidence to supports a role for causal inference in recalibration.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. An adaptable, reusable, and light implant for chronic Neuropixels probes

    This article has 26 authors:
    1. Célian Bimbard
    2. Flóra Takács
    3. Joana A Catarino
    4. Julie MJ Fabre
    5. Sukriti Gupta
    6. Stephen C Lenzi
    7. Maxwell D Melin
    8. Nathanael O'Neill
    9. Ivana Orsolic
    10. Magdalena Robacha
    11. James S Street
    12. José M Gomes Teixeira
    13. Simon Townsend
    14. Enny H van Beest
    15. Arthur M Zhang
    16. Anne K Churchland
    17. Chunyu A Duan
    18. Kenneth D Harris
    19. Dimitri Michael Kullmann
    20. Gabriele Lignani
    21. Zachary F Mainen
    22. Troy W Margrie
    23. Nathalie L Rochefort
    24. Andrew Wikenheiser
    25. Matteo Carandini
    26. Philip Coen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents the design of a new device for using high-density electrophysiological probes ('Neuropixels') in freely moving rodents. The evidence demonstrating the system's versatility and ability to record high-quality extracellular data in both mice and rats is compelling. This study will be of significant interest to neuroscientists performing chronic electrophysiological recordings.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  6. Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

    This article has 11 authors:
    1. Mathias Guayasamin
    2. Lewis R Depaauw-Holt
    3. Ifeoluwa I Adedipe
    4. Ossama Ghenissa
    5. Juliette Vaugeois
    6. Manon Duquenne
    7. Benjamin Rogers
    8. Jade Latraverse-Arquilla
    9. Sarah Peyrard
    10. Anthony Bosson
    11. Ciaran Murphy-Royal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper explores the impact of early life stress (ELS) on adult brain and behavior. The significance of the convincing findings are that they implicate regulation of non-neuronal cells in the development of brain and behavioral dysfunction associated with ELS. With an elegant combination of behavioral models, morphological and functional assessments using immunostaining, electrophysiology, and viral-mediated loss-of-function approaches, the authors report that astrocyte dysfunction plays a role in ELS responses. The work is of interest to a broad behavioral and cellular neuroscience audience.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel

    This article has 3 authors:
    1. Christine Ahrends
    2. Mark W Woolrich
    3. Diego Vidaurre
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study combines the use of Fisher Kernels with Hidden Markov models aiming to improve brain-behaviour prediction. The evidence supporting the authors' conclusions is compelling, comparing brain-behaviour prediction accuracies across a range of different traits, including out of sample assessment. This work is timely and will be of interest to neuroscientists working on functional connectivity for brain-behaviour association.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection

    This article has 7 authors:
    1. Ilya A Rybak
    2. Natalia A Shevtsova
    3. Johannie Audet
    4. Sirine Yassine
    5. Sergey N Markin
    6. Boris I Prilutsky
    7. Alain Frigon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important modeling study alters a previous model of the intact cat spinal locomotor network to simulate a lateral hemi-section of the spinal cord. The modeling and experimental work described provide convincing evidence that this model is capable of qualitatively predicting alterations to the swing and stance phase durations during locomotion at different speeds on intact or split-belt treadmills. This paper will interest neuroscientists studying vertebrate motor systems, including researchers working on motor dysfunction after spinal cord injury.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    This article has 5 authors:
    1. François Kroll
    2. Joshua Donnelly
    3. Güliz Gürel Özcan
    4. Eirinn Mackay
    5. Jason Rihel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important manuscript sets out to identify sleep/arousal phenotypes in larval zebrafish carrying mutations in Alzheimer's disease (AD)-associated genes. The authors provide detailed phenotypic data for F0 knockouts of each of 7 AD-associated genes and then compare the resulting behavioral fingerprints to those obtained from a large-scale chemical screen to generate new hypotheses about underlying molecular mechanisms. The data presented are solid, although extensive interpretation of pharmacological screen data does not necessarily reflect the limited mechanistic data. Nonetheless, the authors address most reviewer concerns in their revised version, providing invaluable new analyses. Phenotypic characterization presented is comprehensive, and the authors develop a well-designed behavioral analysis pipeline that will provide considerable value for zebrafish neuroscientists.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    This article has 4 authors:
    1. Viktor János Oláh
    2. Jing Wu
    3. Leonard K Kaczmarek
    4. Matthew JM Rowan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study the authors use electrophysiology in brain slices and computer modeling and suggest that layer 2/3 pyramidal neurons of the mouse cortex have functional HCN channels on the proximal apical dendrite which allows distinct processing of input at that location from the input to distal apical dendrites. The revisions improved the solid paper but some of the concerns were not addressed sufficiently and many of these concerns could be addressed by further revision.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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