Neuroscience

The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

1. Oriane Onimus
2. Faustine Arrivet
3. Tinaïg Le Borgne
4. Sylvie Perez
5. Julien Castel
6. Anthony Ansoult
7. Benoit Bertrand
8. Nejmeh Mashhour
9. Camille de Almeida
10. Linh-Chi Bui
11. Marie Vandecasteele
12. Serge Luquet
13. Laurent Venance
14. Nicolas Heck
15. Fabio Marti
16. Giuseppe Gangarossa

Reviewed by PREreview

Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

1. Tien Phuoc Tran
2. Bogdan Budnik
3. John E Froberg
4. Jeffrey D Macklis

• Curated by eLife

  eLife Assessment

  This study presents a valuable and rigorous molecular resource, offering subtype-specific insight into the composition of ribosome-associated protein complexes in the developing cerebral cortex. The evidence is compelling in terms of data quality and is strongly supported by the results, given the rigorous technical execution. However, the findings remain primarily descriptive, as the study lacks functional validation to support mechanistic conclusions.

Reviewed by eLife

Co-release of opposing signaling molecules controls the escalation and release of aggression

1. Rachel E. Gatlin
2. Jordyn Gagon
3. Damhyeon Kwak
4. Sewon Park
5. Hailee Walker
6. Lo Kronheim
7. Thomas Everett
8. Ashley Covington
9. Michaela M. Fluck
10. Tobias Zickmund
11. Nicholas A. Frost
12. Moriel Zelikowsky

Reviewed by PREreview

Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

1. Vincent Richter
2. Tilman Triphan
3. Albert Cardona
4. Andreas S Thum

• Curated by eLife

  eLife Assessment

  In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

Reviewed by eLife

RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

1. Daniel Bushey
2. Hiroshi Shiozaki
3. Yichun Shuai
4. Jihong Zheng
5. Vivek Jayaraman
6. Jeremy P Hasseman
7. Ilya Kolb
8. GENIE Project Team
9. Glenn C Turner

• Curated by eLife

  eLife Assessment

  This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

Reviewed by eLife

A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment

1. Igor Bonacossa-Pereira
2. Sean Coakley
3. Massimo A. Hilliard

Reviewed by Review Commons