Neuroscience

Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

1. Vincent Richter
2. Tilman Triphan
3. Albert Cardona
4. Andreas S Thum

• Curated by eLife

  eLife Assessment

  In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

Reviewed by eLife

RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

1. Daniel Bushey
2. Hiroshi Shiozaki
3. Yichun Shuai
4. Jihong Zheng
5. Vivek Jayaraman
6. Jeremy P Hasseman
7. Ilya Kolb
8. GENIE Project Team
9. Glenn C Turner

• Curated by eLife

  eLife Assessment

  This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

Reviewed by eLife

A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment

1. Igor Bonacossa-Pereira
2. Sean Coakley
3. Massimo A. Hilliard

Reviewed by Review Commons

Psychedelics Align Brain Activity with Context

1. Devon Stoliker
2. Leonardo Novelli
3. Moein Khajehnejad
4. Mana Biabani
5. Matthew D. Greaves
6. Tamrin Barta
7. Martin Williams
8. Sidhant Chopra
9. Olivier Bazin
10. Otto Simonsson
11. Richard Chambers
12. Frederick Barrett
13. Gustavo Deco
14. Katrin H. Preller
15. Robin Carhart-Harris
16. Anil Seth
17. Suresh Sundram
18. Gary F. Egan
19. Adeel Razi

Reviewed by preLights

Listening to the room: disrupting activity of dorsolateral prefrontal cortex impairs learning of room acoustics in human listeners

1. Heivet Hernández-Pérez
2. Jessica JM Monaghan
3. Jason Mikiel-Hunter
4. James Traer
5. Paul F Sowman
6. David McAlpine

• Curated by eLife

  eLife Assessment:

  This study addresses valuable questions about the neural mechanisms underlying statistical learning of room acoustics, combining robust behavioral measures with non-invasive brain stimulation. The behavioral findings are strong and extend previous work in psychoacoustics, but the TMS results are modest, with methodological limitations and over-interpretation that weaken the mechanistic conclusions. The strength of evidence is therefore incomplete, and a more cautious interpretation of the stimulation findings, alongside strengthened analyses, would improve the manuscript.

Reviewed by eLife