Neuroscience

Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

1. Jewoo Seo
2. Seung Ha Kim
3. Jaegeon Lee
4. Min Seok Kim
5. Yong-Seok Lee
6. Sang Jeong Kim

• Curated by eLife

  eLife assessment

  This study presents potentially valuable insights into the role of climbing fibers in cerebellar learning. The main claim is that climbing fiber activity is necessary for optokinetic reflex adaptation, but is dispensable for its long-term consolidation. There is evidence to support the first part of this claim, though it requires a clearer demonstration of the penetrance and selectivity of the manipulation. However, support for the latter part of the claim is incomplete owing to methodological concerns, including unclear efficacy of longer-duration climbing fiber activity suppression.

Reviewed by eLife

Value construction through sequential sampling explains serial dependencies in decision making

1. Ariel Zylberberg
2. Akram Bakkour
3. Daphna Shohamy
4. Michael N Shadlen

• Curated by eLife

  eLife assessment

  The authors address key assumptions underlying current models of the formation of value-based decisions. They provide solid evidence that the subjective values human participants assign to choice options change across sequences of multiple decisions and establish valuable methods to detect these changes in frequently used behavioral task designs. That said, the description of the fMRI results requires further elaboration in order to support the claim that the authors' algorithm reveals neural valuation processes better than the current standard approach.

Reviewed by eLife

A Connectome of the Male Drosophila Ventral Nerve Cord

1. Shin-ya Takemura
2. Kenneth J Hayworth
3. Gary B Huang
4. Michal Januszewski
5. Zhiyuan Lu
6. Elizabeth C Marin
7. Stephan Preibisch
8. C Shan Xu
9. John Bogovic
10. Andrew S Champion
11. Han SJ Cheong
12. Marta Costa
13. Katharina Eichler
14. William Katz
15. Christopher Knecht
16. Feng Li
17. Billy J Morris
18. Christopher Ordish
19. Patricia K Rivlin
20. Philipp Schlegel
21. Kazunori Shinomiya
22. Tomke Stürner
23. Ting Zhao
24. Griffin Badalamente
25. Dennis Bailey
26. Paul Brooks
27. Brandon S Canino
28. Jody Clements
29. Michael Cook
30. Octave Duclos
31. Christopher R Dunne
32. Kelli Fairbanks
33. Siqi Fang
34. Samantha Finley-May
35. Audrey Francis
36. Reed George
37. Marina Gkantia
38. Kyle Harrington
39. Gary Patrick Hopkins
40. Joseph Hsu
41. Philip M Hubbard
42. Alexandre Javier
43. Dagmar Kainmueller
44. Wyatt Korff
45. Julie Kovalyak
46. Dominik Krzemiński
47. Shirley A Lauchie
48. Alanna Lohff
49. Charli Maldonado
50. Emily A Manley
51. Caroline Mooney
52. Erika Neace
53. Matthew Nichols
54. Omotara Ogundeyi
55. Nneoma Okeoma
56. Tyler Paterson
57. Elliott Phillips
58. Emily M Phillips
59. Caitlin Ribeiro
60. Sean M Ryan
61. Jon Thomson Rymer
62. Anne K Scott
63. Ashley L Scott
64. David Shepherd
65. Aya Shinomiya
66. Claire Smith
67. Natalie Smith
68. Alia Suleiman
69. Satoko Takemura
70. Iris Talebi
71. Imaan FM Tamimi
72. Eric T Trautman
73. Lowell Umayam
74. John J Walsh
75. Tansy Yang
76. Gerald M Rubin
77. Louis K Scheffer
78. Jan Funke
79. Stephan Saalfeld
80. Harald F Hess
81. Stephen M Plaza
82. Gwyneth M Card
83. Gregory SXE Jefferis
84. Stuart Berg

• Curated by eLife

  eLife assessment

  This landmark paper introduces the generation and analysis of a connectome resource of the entire ventral nerve cord of a fruit fly which is one of the top model organisms to investigate how a nervous system forms and functions. The work introduces new and improved approaches - from tissue preparation to automated reconstruction - to generate a detailed connectome from a complex adult ventral nerve cord. This extensive new dataset provides cell type and lineage annotations, putative neurotransmitter expression information, and the potential to link to genetic driver lines, with compelling evidence to support the claims made.

Reviewed by eLife

An atlas of brain-bone sympathetic neural circuits in mice

1. Vitaly Ryu
2. Anisa Azatovna Gumerova
3. Ronit Witztum
4. Funda Korkmaz
5. Liam Cullen
6. Hasni Kannangara
7. Ofer Moldavski
8. Orly Barak
9. Daria Lizneva
10. Ki A Goosens
11. Sarah Stanley
12. Se-Min Kim
13. Tony Yuen
14. Mone Zaidi

• Curated by eLife

  eLife assessment

  This fundamental work advances our understanding of the central coding and control mechanisms regulating sympathetic nervous system efferent signals to bone. The evidence supporting the conclusion is mostly convincing, although the inclusion of higher resolution images for certain data and further discussions would strengthen the study. This paper holds potential interest for skeletal biologists and neuroscientists who study the brain-bone sympathetic neural circuits.

Reviewed by eLife

White matter structural bases for phase accuracy during tapping synchronization

1. Pamela Garcia-Saldivar
2. Cynthia de León
3. Felipe A Mendez Salcido
4. Luis Concha
5. Hugo Merchant

• Curated by eLife

  eLife assessment

  This paper is valuable in that it provides a critical missing link between measures of structural connectivity and rhythmic tapping abilities, pointing to some interesting possibilities for how tapping synchronization is carried out. The methodology and findings are solid, and of interest to those studying the neural mechanisms of timing.

Reviewed by eLife

Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus

1. Kevin P Koster
2. S Murray Sherman

• Curated by eLife

  eLife assessment

  This investigation marks an important advancement in our understanding of motor thalamus connectivity, illustrating a complex integration of inputs that reshapes previous models. The study utilizes compelling methodologies that expose a dynamic synaptic network, although the evidence of triple-input convergence on individual neurons and for multiple driver type inputs onto motor thalamic neurons remains incomplete. Despite this, the findings provide a persuasive rationale for revisiting our perceptions of the thalamic role in motor control, with a call for further studies to substantiate the breadth of these functional interactions.

Reviewed by eLife

BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity

1. Diana Legutko
2. Bożena Kuźniewska
3. Katarzyna Kalita
4. Ryohei Yasuda
5. Leszek Kaczmarek
6. Piotr Michaluk

Reviewed by Review Commons

Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

1. Ricardo Raudales
2. Gukhan Kim
3. Sean M Kelly
4. Joshua Hatfield
5. Wuqiang Guan
6. Shengli Zhao
7. Anirban Paul
8. Yongjun Qian
9. Bo Li
10. Z Josh Huang

• Curated by eLife

  eLife assessment

  The authors develop a novel genetic strategy for specific and comprehensive labeling of axo-axonic cells, also referred to as chandelier cells, in the mouse brain. The approach and analysis are rigorous such that the data convincingly support the key conclusions, including the expanded distribution of axo-axonic cells throughout the brain. This study provides important new information about the distribution of a significant neuronal cell type, as well as new tools for future studies. This work will be of broad interest to neuroscientists who work on the anatomical and functional organization of neural circuits.

Reviewed by eLife

Brain age has limited utility as a biomarker for capturing fluid cognition in older individuals

1. Alina Tetereva
2. Narun Pat

• Curated by eLife

  eLife assessment

  This useful manuscript challenges the utility of current paradigms for estimating brain-age with magnetic resonance imaging measures. It presents solid evidence to support the suggestion that an alternative approach focused on predicting cognition may be more beneficial. This work will be of interest to researchers working on brain-age and related models.

Reviewed by eLife

Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

1. Patricia E Phelps
2. Sung Min Ha
3. Rana R Khankan
4. Mahlet A. Mekonnen
5. Giovanni Juarez
6. Kaitlin L. Ingraham Dixie
7. Yen-Wei Chen
8. Xia Yang

• Curated by eLife

  eLife assessment

  This study presents important data describing cell states of olfactory ensheathing cells, and how these cell states may relate to repair after spinal cord injury. While the overall framework used for characterizing these cells is solid, the quantification and contextualization of results are incomplete, given that measurements, significance statistics, and discussion of both previous work and experimental methods that would be necessary to support several claims are not provided. With more thorough quantification and discussion, this work will be of interest to stem cell biologists and spinal cord injury researchers.

Reviewed by eLife