Neuroscience

Synaptic density and relative connectivity conservation maintain circuit stability across development

1. Ingo Fritz
2. Feiyu Wang
3. Ricardo Chirif
4. Nikos Malakasis
5. Julijana Gjorgjieva
6. André Ferreira Castro

• Curated by eLife

  eLife Assessment

  The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself is solid, the authors have drawn broader conclusions than are directly supported by the presented data. With more measured claims and greater clarity and explanations for the analysis, the study could potentially become stronger.

Reviewed by eLife

Comparing electromyography, accelerometry, and visual inspection to assess the resting motor threshold for transcranial magnetic stimulation

1. Gautier Hamoline
2. Antoine E Lunardi
3. Marcos Moreno-Verdú
4. Baptiste M Waltzing
5. Elise E Van Caenegem
6. Siobhan MacAteer
7. Robert M Hardwick

Reviewed by Peer Community in Neuroscience

Combined transcriptomic, connectivity, and activity profiling of the medial amygdala using highly amplified multiplexed in situ hybridization (hamFISH)

1. Mathew D Edwards
2. Ziwei Yin
3. Risa Sueda
4. Alina Gubanova
5. Chang S Xu
6. Virág Lakner
7. Megan Murchie
8. Chi-Yu Lee
9. Kristal Ng
10. Karolina Farrell
11. Rupert Faraway
12. Subham Ganguly
13. Elina Jacobs
14. Bogdan Bintu
15. Yoh Isogai

• Curated by eLife

  eLife Assessment

  The study presents important findings that are highly relevant for research aiming to combine transcriptomics, connectivity studies, and activity profiling in the rodent brain and the revisions improve the study. The evidence overall remains convincing as the authors use appropriate and validated methodology in line with current state-of-the-art.

Reviewed by eLife

Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples

1. Hanna den Bakker
2. Fabian Kloosterman

• Curated by eLife

  eLife Assessment

  This useful study reports analyses of Neuropixel recordings in the medial prefrontal cortex and hippocampus of rats in a spatial navigation trial, focusing on classifying prefrontal neurons based on SWR modulation and anatomical location. Reviewers were unconvinced by the presented evidence for the claim that distinct populations of mPFC neurons participate in non-local ensemble representations during SWR and non-SWR periods, and were unconvinced by the presented evidence for a previously unrecognized anatomical distinction between these populations. Further analyses might strengthen the incomplete evidence for some conclusions, and some of the strong claims of the paper should likely be moderated.

Reviewed by eLife