Neuroscience

Molecular Architecture and Function Mechanism of Tri-heteromeric GluN1-N2-N3A NMDA Receptors

1. Zengwei Kou
2. Fenyong Yao
3. Tongtong Zhang
4. Nan Song
5. Chun Xie
6. Boshuang Wang
7. Yidi Sun

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of NMDAR diversity in the brain by providing evidence into the subunit arrangement, architecture, and activation mechanism of GluN1-N2-N3A tri-NMDAR. However, the evidence supporting the conclusions provides incomplete proof for the presence and functional properties of this NMDA receptor subtype. The work will be of broad interest to neuroscientists and biophysicists.

Reviewed by eLife

Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate

1. Léo Dupuis
2. Lolie Garcia
3. Fanny Petit
4. Suzanne Lam
5. Helène Hirbec
6. Jean-Luc Picq
7. Delphine Boche
8. Marc Dhenain

Reviewed by preLights

Molecular and Neural Circuit Mechanisms Underlying Sexual Experience-dependent Long-Term Memory in Drosophila.

1. Dongyu Sun
2. Xiaoli Zhang
3. Hongyu Miao
4. Tianmu Zhang
5. Woo Jae Kim

Reviewed by Review Commons

A stretching mechanism evokes mechano-electrical transduction in auditory chordotonal neurons

1. Atitheb Chaiyasitdhi
2. Manuela Nowotny
3. Marcel Van der Heijden
4. Benjamin Warren

• Curated by eLife

  eLife Assessment

  This valuable study uses a sophisticated array of techniques to investigate the mechanisms through which the chordotonal receptors in the locust ear (Müller's organ) sense auditory signals. Ultrastructural reconstruction of the sensory organ provides convincing evidence of the organization of the scolopidial structure that wraps the sensory neuron cilium. However, the recordings of sound-evoked motion and electrophysiological activity from the chordotonal sensory neurons provide incomplete evidence for the proposed axial stretch model of mechanotransduction.

Reviewed by eLife

Time-adaptive modulation of evidence evaluation in rat posterior parietal cortex

1. Preetham Ganupuru
2. Adam B Goldring
3. Tanner Stevenson
4. Kendall Stewart
5. Rishidev Chaudhuri
6. Timothy D Hanks

• Curated by eLife

  eLife Assessment

  This valuable study examined the roles of the posterior parietal cortex in rats performing an auditory change-detection decision task. It provided solid evidence for two subpopulations with opposing modulation patterns during decision formation and for a correspondence between neural and behavioral measures of the short timescale used for evidence evaluation.

Reviewed by eLife

Effects of transcranial photobiomodulation on peripheral biomarkers associated with oxidative stress and complex IV activity in the prefrontal cortex in rats subjected to chronic mild stress

1. Luciana Bortoluzzi
2. Rafael Colombo
3. Karoline Motta Pinto
4. Lucas Henriques Viscardi
5. Ricardo Missiaggia
6. Douglas Jean Turella
7. Lisandra Schwantess
8. Mirian Salvador
9. Catia Santos Branco
10. Marina Rigotti
11. Ellen Scotton
12. Tainá Schons
13. Silene Bazi Ribeiro
14. Marco Antonio Caldieraro
15. Adriane R Rosa

Reviewed by preLights