1. Dimorphic Neural Network Architecture Prioritizes Sexual-related Behaviors in Male C. elegans

    This article has 15 authors:
    1. Xuebin Wang
    2. Hanzhang Liu
    3. Wenjing Yang
    4. Jingxuan Yang
    5. Xuehong Sun
    6. Qiuhan Liu
    7. Ying Zhu
    8. Yinghao Sun
    9. Chunxiuzi Liu
    10. Guiyuan Shi
    11. Qiang Liu
    12. Ke Zhang
    13. Zengru Di
    14. Wenxing Yang
    15. He Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents useful findings on the differences between male and hermaphrodite C. elegans connectomes and how they may result in changes in locomotory behavioural outputs. However, the study appears incomplete with respect to the relationship between sex-specific AVA wiring and male mate-finding. Another area of concern is that the analysis does not consider animal-to-animal variability in the wiring when attempting to identify significant differences between the male and hermaphrodite.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    This article has 6 authors:
    1. Tanja Fuchsberger
    2. Imogen Stockwell
    3. Matty Woods
    4. Zuzanna Brzosko
    5. Ingo H Greger
    6. Ole Paulsen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript addresses a mechanism by which dopamine (DA) regulates synaptic plasticity. The authors build upon their previous finding that DA applied after a timing pattern that ordinarily induces long-term depression (LTD) now induces long-term potentiation (LTP). The new findings that this "DA-dependent LTP" involves de novo protein synthesis, a cyclicAMP signalling pathway, and calcium-permeable AMPA receptors (CP-AMPARs) are of valuable significance. The conclusions are convincing and largely supported by the evidence provided.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. The value of initiating a pursuit in temporal decision-making

    This article has 4 authors:
    1. Elissa Sutlief
    2. Charlie Walters
    3. Tanya Marton
    4. Marshall G Hussain Shuler
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The paper presents a valuable theoretical treatment of the role of passage of time in optimal decision strategies in pursuit based tasks. The computational evidence and methodologies employed are novel, and the authors offer solid evidence for the majority of the claims.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Biophysical network modeling of temporal and stereotyped sequence propagation of neural activity in the premotor nucleus HVC

    This article has 3 authors:
    1. Zeina Bou Diab
    2. Marc Chammas
    3. Arij Daou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Birdsong production depends on precise neural sequences in a vocal motor nucleus HVC. In this useful biophysical model, Daou and colleagues identify specific biophysical parameters that result in sparse neural sequences observed in vivo. While the model is presently incomplete because it is overfit to produce sequences and therefore not robust to real biological variation, the model has the potential to address some outstanding issues in HVC function.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    This article has 2 authors:
    1. Richa Sirmaur
    2. Rishikesh Narayanan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable theoretical exploration on the electrophysiological mechanisms of ionic currents via gap junctions in hippocampal CA1 pyramidal-cell models, and their potential contribution to local field potentials (LFPs) that is different from the contribution of chemical synapses. The biophysical argument regarding electric dipoles appears solid, but the evidence would be stronger if their predictions are tested against experiments. A shortage of model validation and strictly comparable parameters used in the comparisons between chemical vs. junctional inputs makes the modeling approach incomplete; once strengthened, the finding can be of broad interest to electrophysiologists, who often make recordings from regions of neurons interconnected with gap junctions.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Early changes in the properties of CA3 engram cells explored with a novel viral tool

    This article has 8 authors:
    1. Dario Cupollilo
    2. Noëlle Grosjean
    3. Catherine Marneffe
    4. Julio Viotti
    5. Célia Reynaud
    6. Séverine Deforges
    7. Mario Carta
    8. Christophe Mulle
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study characterizes and validates a new activity marker - fast labelling of engram neurons (FLEN) - which is transiently active and driven by cFos, allowing the monitoring of intrinsic and synaptic properties of engram neurons shortly after the learning experience. The results convincingly demonstrate the utility of this novel viral tool for studying early changes in the properties of engram cells. However, the study would benefit from exploring how accurately FLEN reflects endogenous cFos activity, how this labelling technique compares to previous versions, and from careful consideration of alternative explanations such as changes in release probability.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Accelerated signal propagation speed in human neocortical dendrites

    This article has 10 authors:
    1. Gáspár Oláh
    2. Rajmund Lákovics
    3. Sapir Shapira
    4. Yonatan Leibner
    5. Attila Szücs
    6. Éva Adrienn Csajbók
    7. Pál Barzó
    8. Gábor Molnár
    9. Idan Segev
    10. Gábor Tamás
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable observations indicating that human pyramidal neurons propagate information as fast as rat pyramidal neurons despite their larger size. Convincing evidence demonstrates that this property is due to several biophysical properties of human neurons. This study will be of interest to neurophysiologists.

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    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  8. Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

    This article has 4 authors:
    1. Matthew Davenport
    2. Ha Na Choe
    3. Hiroaki Matsunami
    4. Erich Jarvis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study is valuable as it provides information about the genes regulated by sex hormone treatment in song nuclei and other brain regions and suggests candidate genes that might induce sexual dimorphism in the zebra finch brain. The analysis presented is thorough and detailed. Whereas the evidence for gene regulation by hormone treatment is well supported, the evidence for an association of those genes with song learning (as written in the title) is incompletely supported as no manipulation of song learning or song analysis was conducted.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Chemogenetic stimulation of phrenic motor output and diaphragm activity

    This article has 7 authors:
    1. Ethan S Benevides
    2. Prajwal P Thakre
    3. Sabhya Rana
    4. Michael D Sunshine
    5. Victoria N Jensen
    6. Karim Oweiss
    7. David D Fuller
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors report that chemogenetic methods targeting the ventral cervical spinal cord can be used to increase phrenic inspiratory motor output and subsequent diaphragm EMG activity and ventilation in rodents. These findings are important because they are a necessary first step towards using chemogenetic methods to drive inspiratory activity in disorders in which motor neurons are compromised, such as spinal injury and degenerative disease. The data are convincing, with rigorous assessments of phrenic inspiratory activity and its ability to drive the diaphragm and subsequent ventilation, as well as assessments of DREADD expression.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles

    This article has 19 authors:
    1. Lizi Zhang
    2. Yishan Qu
    3. Larry J Young
    4. Wenjuan Hou
    5. Limin Liu
    6. Jing Liu
    7. Yuqian Wang
    8. Lu Li
    9. Xing Guo
    10. Yin Li
    11. Caihong Huang
    12. Zijian Lv
    13. Yi-Tong Li
    14. Rui Jia
    15. Ting Lian
    16. Hao Feng
    17. Hui Qiao
    18. Zhixiong He
    19. Fa-Dao Tai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study advances our understanding of the role of dopamine in modulating pair bonding in mandarin voles by examining dopamine signaling within the nucleus accumbens across various social stimuli using state-of-the-art causal perturbations. The evidence supporting the findings is compelling, particularly cutting-edge approaches for measuring dopamine release as well as the activity of dopamine receptor populations during social bonding. Some concerns remain about the statistical analyses.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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