Neuroscience

The Good, the Bad, and the Ugly: Segmentation-Based Quality Control of Structural Magnetic Resonance Images

1. Robert Dahnke
2. Polona Kalc
3. Gabriel Ziegler
4. Julian Grosskreutz
5. Christian Gaser

Reviewed by GigaScience

Distributed neural computation and the evolution of the first brains

1. Vikram Chandra
2. Mehrana R. Nejad
3. Allison P. Kann
4. Ananya Salem
5. Karl A.P. Hill
6. Richard Schalek
7. Jeff Lichtman
8. L. Mahadevan
9. Mansi Srivastava

Reviewed by PREreview

PKD2L1 channels segregated to the apical compartment are the exclusive dual-mode pH sensor in cerebrospinal fluid-contacting neurons

1. Magdalena Vitar
2. Daniel Prieto
3. Stavros Malas
4. Raúl E Russo
5. Federico F Trigo

• Curated by eLife

  eLife Assessment

  This is an important study on the sensory roles of Cerebrospinal fluid-contacting neurons (CBF-cn) in mammals. The authors identify PKD2L1 as the predominant pH-sensing channel CBF-cn and show how the apical extension is used as an amplifier of chemical changes in the content of the Cerebrospinal fluid. The evidence is solid in experimental design but limited in mechanistic interpretation, as the electrophysiological analyses require re-evaluation.

Reviewed by eLife

Spatial learning in multi-scale environments: Roles of hippocampus, orbitofrontal cortex, and retrosplenial cortex

1. Yidan Qiu
2. Senning Zheng
3. Huakang Li
4. Shuting Lin
5. Ruiwang Huang

• Curated by eLife

  eLife Assessment

  The goal of this useful study is to examine learning-related changes in neural representations of global and local spatial reference frames in a spatial navigation task. Although the study addresses an interesting question, the evidence for neural representations in the hippocampus and retrosplenial cortex remains incomplete because of confounds in the experimental design and partial data analysis. There are further concerns about the framing of the study in the context of the relevant literature as well as the discussion.

Reviewed by eLife