1. The asymmetric transfers of visual perceptual learning determined by the stability of geometrical invariants

    This article has 5 authors:
    1. Yan Yang
    2. Yan Zhuo
    3. Zhentao Zuo
    4. Tiangang Zhuo
    5. Lin Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important and unique study proposes a framework to understand and predict generalization in visual perceptual learning in humans based on form invariants. Using behavioral experiments in humans and by training deep networks, the authors offer evidence that the presence of stable invariants in a task leads to faster learning. However, this interpretation is promising but counter-intuitive and incomplete, since there could be possible other confounds such as differing attentional demands that lead to differing patterns of generalization. It can be strengthened through additional experiments and by rejecting alternate explanations.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Efficient coding explains neural response homeostasis and stimulus-specific adaptation

    This article has 2 authors:
    1. Edward James Young
    2. Yashar Ahmadian
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work derives a valuable general theory unifying theories of efficient information transmission in the brain with population homeostasis. The general theory provides an explanation for firing rate homeostasis at the level of neural clusters with firing rate heterogeneity within clusters. Applying this theory to the primary visual cortex, the authors present solid evidence that accounts for stimulus-specific and neuron-specific adaptation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish

    This article has 4 authors:
    1. Emanuele Paoli
    2. Virginia Palieri
    3. Amey Shenoy
    4. Ruben Portugues

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Distinct representational properties of cues and contexts shape fear learning and extinction

    This article has 7 authors:
    1. Antoine Bouyeure
    2. Daniel Pacheco
    3. Marie-Christin Fellner
    4. George Jacob
    5. Malte Kobelt
    6. Jonas Rose
    7. Nikolai Axmacher
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study with solid evidence that multi-voxel fMRI activity patterns for threat-conditioned stimuli are altered by learning CS-US contingencies. The analyses are dense but mostly rigorous. The protocol is quite nuanced and complex, but the authors have done a fair job of explaining and presenting the results, and the results could be further improved by adjustment for multiple comparisons. The readability could be improved for an audience without highly-specialised knowledge of the field and the fMRI analytical approach.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

    This article has 16 authors:
    1. Ayni Sharif
    2. Matthew S Jeffers
    3. Dean A Fergusson
    4. Raj Bapuji
    5. Stuart G Nicholls
    6. John Humphrey
    7. Warren Johnston
    8. Ed Mitchell
    9. Mary-Ann Speirs
    10. Laura Stronghill
    11. Michele Vuckovic
    12. Susan Wulf
    13. Risa Shorr
    14. Dar Dowlatshahi
    15. Dale Corbett
    16. Manoj M Lalu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected systematic review and meta-analysis standards, and the presented evidence is convincing.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Insights into the foraging Gene’s Influence on Mating Investments of Male Drosophila

    This article has 3 authors:
    1. Wengjing Li
    2. Yongwen Huang
    3. Woo Jae Kim

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

    This article has 7 authors:
    1. Tanya Wolff
    2. Mark Eddison
    3. Nan Chen
    4. Aljoscha Nern
    5. Preeti Sundaramurthi
    6. Divya Sitaraman
    7. Gerald M Rubin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a fundamental body of work reporting anatomical, molecular, and functional mapping of the central complex in Drosophila. There were a few concerns of a minor nature, and all were addressed by the authors. The tools generated and the findings, which include characterization of neuromodulators used by different cells, will undoubtedly serve as a foundation for future studies of this brain region. The data are compelling and likely to have a major impact.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. The neural correlates of novelty and variability in human decision-making under an active inference framework

    This article has 4 authors:
    1. Shuo Zhang
    2. Yan Tian
    3. Quanying Liu
    4. Haiyan Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study addresses a central question in systems neuroscience (validation of active inference models of exploration) using a combination of behaviour, neuroimaging, and modelling. The data provided offers solid evidence that humans do perceive, choose and learn in a manner consistent with the essential ingredients of active inference, and that quantities that correlate with relevant parameters of this active inference scheme are encoded in different regions of the brain.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  9. Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models

    This article has 15 authors:
    1. Ulrike Pech
    2. Jasper Janssens
    3. Nils Schoovaerts
    4. Sabine Kuenen
    5. Carles Calatayud Aristoy
    6. Sandra F Gallego
    7. Samira Makhzami
    8. Gert J Hulselmans
    9. Suresh Poovathingal
    10. Kristofer Davie
    11. Adekunle T Bademosi
    12. Jef Swerts
    13. Sven Vilain
    14. Stein Aerts
    15. Patrik Verstreken
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study demonstrating that anosmia in Parkinson's disease patients is due to dysfunction in cholinergic neurons. This study provides compelling evidence, using scRNA sequencing, that cholinergic olfactory projection neurons (OPN) are consistently affected in five different fruit fly models of Parkinson's disease, exhibiting synaptic dysfunction before the onset of motor deficits. Comparisons with scRNA sequencing of patients' human brain samples reveals similar synaptic gene deregulation in cholinergic neurons of patients. This study points the possibility that targeting cholinergic neurons could be a potential avenue for early diagnosis and intervention in PD.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Whole-body connectome of a segmented annelid larva

    This article has 7 authors:
    1. Csaba Verasztó
    2. Sanja Jasek
    3. Martin Gühmann
    4. Luis Alberto Bezares-Calderón
    5. Elizabeth A Williams
    6. Réza Shahidi
    7. Gáspár Jékely
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study is an advancement towards the understanding of animal nervous system organization and evolution by providing an exceptional, high-quality and detailed description of the entire connectome of the 3-day larva of the marine annelid Platynereis dumerilii. It provides a wealth of data on cell type diversity and the modules that interconnect them. Its strength is the massive amount of high-quality data, although this is also partly a weakness as it can make the work difficult to read and digest scientifically. This work lays the foundations for studies on cell type diversity, segmental vs. intersegmental connectivity, and mushroom bodies, but will certainly also be of use to scientists interested in other nervous systems parts, their functions, and evolution.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
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