Neuroscience

  1. Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    1. Ann-Kathrin Joechner
    2. Michael A Hahn
    3. Georg Gruber
    4. Kerstin Hoedlmoser
    5. Markus Werkle-Bergner

    • Curated by eLife

      eLife assessment

      This is an important analysis of two sleep datasets in children and adolescents that contributes to our understanding of sleep spindle and slow oscillation dynamics during development and is expected to be of interest to interdisciplinary fields including development and sleep. The analyses are solid and adequately complex to capture the changes in sleep spindle to slow oscillation coupling between the age groups. However, the paper would be strengthened by performing the same analyses in an adult sample to sufficiently characterize the maturation of sleep spindles and their coupling to slow oscillations.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI

    1. Alena U. Uus
    2. Vanessa Kyriakopoulou
    3. Antonios Makropoulos
    4. Abi Fukami-Gartner
    5. Daniel Cromb
    6. Alice Davidson
    7. Lucilio Cordero-Grande
    8. Anthony N. Price
    9. Irina Grigorescu
    10. Logan Z. J. Williams
    11. Emma C. Robinson
    12. David Lloyd
    13. Kuberan Pushparajah
    14. Lisa Story
    15. Jana Hutter
    16. Serena J. Counsell
    17. A. David Edwards
    18. Mary A. Rutherford
    19. Joseph V. Hajnal
    20. Maria Deprez

    • Curated by eLife

      eLife assessment

      This study proposes a deep learning-based segmentation pipeline of fetal brain MRI, with parcellation based on a newly implemented atlas. This represents an important contribution to the field of developmental neuroscience and pediatric neuroimaging, especially as the pipeline and atlas are publicly available. The evidence for the pipeline robustness and atlas relevance is convincing given the extensive validations provided and the very high-quality ground truth dataset. Although beyond the state of the art, the study would benefit from further comparisons with existing methods and additional evaluations of the framework generalizability according to image quality, subject age or brain abnormalities.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease

    1. Priya Prakash
    2. Palak Manchanda
    3. Evi Paouri
    4. Kanchan Bisht
    5. Kaushik Sharma
    6. Jitika Rajpoot
    7. Victoria Wendt
    8. Ahad Hossain
    9. Prageeth R. Wijewardhane
    10. Caitlin E. Randolph
    11. Yihao Chen
    12. Sarah Stanko
    13. Nadia Gasmi
    14. Anxhela Gjojdeshi
    15. Sophie Card
    16. Jonathan Fine
    17. Krupal P. Jethava
    18. Matthew G. Clark
    19. Bin Dong
    20. Seohee Ma
    21. Alexis Crockett
    22. Elizabeth A. Thayer
    23. Marlo Nicolas
    24. Ryann Davis
    25. Dhruv Hardikar
    26. Daniela Allende
    27. Richard A. Prayson
    28. Chi Zhang
    29. Dimitrios Davalos
    30. Gaurav Chopra

    Reviewed by PREreview

    1 evaluationAppears in 3 listsLatest version Latest activity

  4. Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    1. Subhash Kulkarni
    2. Monalee Saha
    3. Jared Slosberg
    4. Alpana Singh
    5. Sushma Nagaraj
    6. Laren Becker
    7. Chengxiu Zhang
    8. Alicia Bukowski
    9. Zhuolun Wang
    10. Guosheng Liu
    11. Jenna M Leser
    12. Mithra Kumar
    13. Shriya Bakhshi
    14. Matthew J Anderson
    15. Mark Lewandoski
    16. Elizabeth Vincent
    17. Loyal A Goff
    18. Pankaj Jay Pasricha

    • Curated by eLife

      eLife assessment

      This paper identifies a subset of neurons within adult mouse myenteric ganglia that are not labeled via canonical neural-crest labeling, and argues, based on extensive lineage tracing, imaging and genomic data that these neurons are derived from mesoderm. There is convincing evidence for the existence of an unusual cell type in the gut that expresses neuronal markers, but which is derived from cells expressing markers of the mesoderm rather than the expected neural crest, which is an intriguing and important observation. While the data do not definitively establish the molecular taxonomy of this lineage, there is sufficient evidence to support the provocative and paradigm-shifting hypothesis of the non-ectodermal origin for enteric neurons to warrant further deeper investigation.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  5. Functional Sexual Dimorphism in Human Nociceptors

    1. Harrison Stratton
    2. Mahdi Dolatyari
    3. Nicolas Dumaire
    4. Aubin Moutal
    5. Andre Ghetti
    6. Tamara Cotta
    7. Stefanie Mitchell
    8. Xu Yue
    9. Edita Navratilova
    10. Frank Porreca

    Reviewed by Arcadia Science

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Inhibitory input directs astrocyte morphogenesis through glial GABABR

    1. Yi-Ting Cheng
    2. Estefania Luna-Figueroa
    3. Junsung Woo
    4. Hsiao-Chi Chen
    5. Zhung-Fu Lee
    6. Akdes Serin Harmanci
    7. Benjamin Deneen

    Reviewed by Arcadia Science

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

    1. Malika S. Datta
    2. Yannan Chen
    3. Shradha Chauhan
    4. Jing Zhang
    5. Estanislao Daniel De La Cruz
    6. Cheng Gong
    7. Raju Tomer

    Reviewed by Arcadia Science

    9 evaluationsAppears in 1 listLatest version Latest activity

  8. 2-Photon imaging of fluorescent proteins in living swine

    1. Beth A. Costine-Bartell
    2. Luis Martinez-Ramirez
    3. Kieran Normoyle
    4. Tawny Stinson
    5. Kevin J. Staley
    6. Kyle P. Lillis

    Reviewed by Arcadia Science

    6 evaluationsAppears in 2 listsLatest version Latest activity

  9. A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

    1. Marito Hayashi
    2. Miriam Gullo
    3. Gokhan Senturk
    4. Stefania Di Costanzo
    5. Shinji C. Nagasaki
    6. Ryoichiro Kageyama
    7. Itaru Imayoshi
    8. Martyn Goulding
    9. Samuel L. Pfaff
    10. Graziana Gatto

    • Curated by eLife

      eLife assessment

      This study makes important contributions to our understanding of spinal locomotor circuits by manipulating the function of excitatory and inhibitory V2 interneurons and revelaing their role in locomotor control. The data collected and the methods used by the authors are solid and the authors suggest that V2 excitatory and inhibitory neurons have antagonistic functions in intralimb coordination. This work will be of broad interest for neuroscientists studying development and function of motor circuits.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Monitoring norepinephrine release in vivo using next-generation GRAB NE sensors

    1. Jiesi Feng
    2. Hui Dong
    3. Julieta Lischinsky
    4. Jingheng Zhou
    5. Fei Deng
    6. Chaowei Zhuang
    7. Xiaolei Miao
    8. Huan Wang
    9. Hao Xie
    10. Guohong Cui
    11. Dayu Lin
    12. Yulong Li

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity
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