Neuroscience

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

1. Bohan Zhu
2. Richard I Ainsworth
3. Zengmiao Wang
4. Zhengzhi Liu
5. Salvador Sierra
6. Chengyu Deng
7. Luis F Callado
8. J Javier Meana
9. Wei Wang
10. Chang Lu
11. Javier González-Maeso

• Curated by eLife

  eLife assessment

  The study by Zhu et al. provides important insights into cell-specific genome-wide histone modifications in the frontal cortex of individuals with schizophrenia, as well as shedding light on the role of age and antipsychotic treatment in these associations. The evidence supporting the conclusions is solid.

Reviewed by eLife

Plastic vasomotion entrainment

1. Daichi Sasaki
2. Ken Imai
3. Yoko Ikoma
4. Ko Matsui

• Curated by eLife

  eLife assessment

  This manuscript presents important results indicating a plastic enhancement in the vasomotion response of pial cortical arterioles to external stimulation in awake mice using a wide range of external visual stimulation paradigms. The evidence for this interesting effect, with broad potential applications, is solid. These results are relevant for scientists and clinicians interested in the regulation of blood flow in the brain.

Reviewed by eLife

Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

1. Evan D Vickers
2. David A McCormick

• Curated by eLife

  eLife assessment

  This important paper presents a thoroughly detailed methodology for mesoscale-imaging of extensive areas of the cortex, either from a top or lateral perspective, in behaving mice. The examples of scientific results to be derived with this method offer promising and stimulating insights. Overall, the method and results presented are convincing and will be of interest to neuroscientists focused on cortical processing in rodents and beyond.

Reviewed by eLife

Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

1. Blake J Laham
2. Isha R Gore
3. Casey J Brown
4. Elizabeth Gould

• Curated by eLife

  eLife assessment

  This paper reports a valuable set of new results. The main result is that the projection from adult-born granule cells in the dentate gyrus to the hippocampal subfield CA2 is necessary for the retrieval of a social memory formed during development, and solid evidence is provided to support this conclusion.

Reviewed by eLife

Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

1. Alyssa D Huff
2. Marlusa Karlen-Amarante
3. Luiz M Oliveira
4. Jan-Marino Ramirez

• Curated by eLife

  eLife assessment

  This important study represents a follow-up of previous papers by Huff et al. (2023) in which the authors further investigate a specific medullary region named the Postinspiratory Complex (PiCo) involved in the control of swallow behaviour and its coordination with breathing. In the present work, they tested the impact of chronic intermittent hypoxia on the swallow motor pattern evoked by optogenetic stimulation of the same medullary area in transgenic mice. These solid results indicate that in chronic intermittent hypoxia-exposed mice PiCo stimulation triggers atypical swallow motor patterns. The experimental procedures are rigorous and technically remarkable. The work will be of interest in the field of respiratory physiology and pathophysiology since a disruption of swallowing and possibly discoordination with breathing may be involved in diseases characterized by the presence of hypoxic conditions such as obstructive sleep apnea.

Reviewed by eLife

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

1. Bojana Kokinovic
2. Patricia Seja
3. Angelica Donati
4. Maria Ryazantseva
5. Alban de Kerchove d’Exaerde
6. Serge N. Schiffmann
7. Tomi Taira
8. Svetlana M. Molchanova

• Curated by eLife

  eLife assessment

  This valuable study describes early postnatal compartmental differences in the functional maturation of striatal projection neurons. It explores how the postnatal activity of these neurons may determine the GABAergic innervation of dopaminergic neurons in the adult substantia nigra pars compacta. While the functional characterization of striatal neuron development is solid, analysis of how early postnatal activity of striatal projection neurons shapes their functional innervation of dopaminergic neurons is incomplete.

Reviewed by eLife

Microglia contact cerebral vasculature through gaps between astrocyte endfeet

1. Gary P Morris
2. Catherine G Foster
3. Brad A Sutherland
4. Søren Grubb

Reviewed by Arcadia Science

Sibling chimerism among microglia in marmosets

1. Ricardo C.H. del Rosario
2. Fenna M. Krienen
3. Qiangge Zhang
4. Melissa Goldman
5. Curtis Mello
6. Alyssa Lutservitz
7. Kiku Ichihara
8. Alec Wysoker
9. James Nemesh
10. Guoping Feng
11. Steven A. McCarroll

• Curated by eLife

  eLife assessment

  This fundamental study substantially advances our understanding of sibling chimerism in marmosets by demonstrating that chimerism is limited to hematopoietic cells. The evidence supporting these findings is compelling, demonstrated through comprehensive analyses, including single-cell RNA-seq data from multiple individuals and tissues. The work will be of broad interest to many fields of biology.

Reviewed by eLife

Unveiling the cell biology of hippocampal neurons with dendritic axon origin

1. Yuhao Han
2. Daniela Hacker
3. Bronte Catharina Donders
4. Christopher Parperis
5. Roland Thuenauer
6. Christophe Leterrier
7. Kay Grünewald
8. Marina Mikhaylova

Reviewed by Review Commons

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

1. Junjun Yao
2. Shaoxing Dai
3. Ran Zhu
4. Ju Tan
5. Qiancheng Zhao
6. Yu Yin
7. Jiansen Sun
8. Xuewei Du
9. Longjiao Ge
10. Jianhua Xu
11. Chunli Hou
12. Nan Li
13. Jun Li
14. Weizhi Ji
15. Chuhong Zhu
16. Runrui Zhang
17. Tianqing Li

• Curated by eLife

  eLife assessment

  Using state-of-the-art single-nucleus RNA sequencing, Yao et al. investigate the transcriptomic features of neural stem cells (NSCs) in the human hippocampus to address how they vary across different age groups and stroke conditions. The authors report alterations in NSC subtype proportions and gene expression profiles after stroke. Although the study is valuable and the analysis is comprehensive, the significance is restricted by well-acknowledged technical limitations leading to incomplete evidence supporting some main conclusions.

Reviewed by eLife