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Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

This article has 10 authors:
1. Julian Bartram
2. Felix Franke
3. Sreedhar Saseendran Kumar
4. Alessio Paolo Buccino
5. Xiaohan Xue
6. Tobias Gänswein
7. Manuel Schröter
8. Taehoon Kim
9. Krishna Chaitanya Kasuba
10. Andreas Hierlemann
This article has been curated by 1 group:
- Curated by eLife
  
  eLife assessment
  
  This study makes an important effort to observe and quantify synaptic integration in a large and active network of cultured neurons, using simultaneous patch-clamp and large-scale extracellular recordings. They developed a method to distinguish excitatory and inhibitory contributions, show compelling evidence that the subthreshold activity of these neurons is dominated by few presynaptic neurons. They provide convincing statistics about connectivity and network dynamics.
Reviewed by eLife

This article has 7 evaluationsAppears in 1 listLatest version Sep 26, 2024Latest activity Sep 24, 2024
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10.1101/2023.05.26.542533
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Neuroscience

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Curated by eLife