Neuroscience

Visuo-motor updating in individuals with heightened autistic traits

1. Antonella Pomè
2. Eckart Zimmermann

• Curated by eLife

  eLife assessment

  This important study shows that a high autism quotient in neurotypical adults is associated with suboptimal motor planning and visual updating after eye movements, suggesting a disrupted efference copy mechanism. The implication is that abnormal visuomotor updating may contribute to sensory overload - a key symptom in autism spectrum disorder. The evidence presented is convincing, with few limitations, and should be of broad interest to neuroscientists at large.

Reviewed by eLife

The scheduling of adolescence with Netrin-1 and UNC5C

1. Daniel Hoops
2. Robert Kyne
3. Samer Salameh
4. Del MacGowan
5. Radu Gabriel Avramescu
6. Elise Ewing
7. Alina Tao He
8. Taylor Orsini
9. Anais Durand
10. Christina Popescu
11. Janet Mengyi Zhao
12. Kelcie Shatz
13. LiPing Li
14. Quinn Carroll
15. Guofa Liu
16. Matthew J Paul
17. Cecilia Flores

• Curated by eLife

  eLife assessment

  This study addresses an important, understudied question using approaches that link molecular, circuit, and behavioral changes. The findings that Netrin-1 and UNC5c can guide dopaminergic innervation from the nucleus accumbens to the cortex during adolescence are solid. The data showing that the onset of Unc5 expression is sexually dimorphic in mice, and that in Siberian hamsters environmental effects on development are also sexually dimorphic are also solid. Reviewers identified significant gaps in evidence for specificity of Netrin-1 expression, which, if filled, would strengthen the evidence for some of the claims. Future work would also benefit from Unc5C knockdown to corroborate the results and investigation of the cause-effect relationship. This paper will be of interest to those interested in neural development, sex differences, and/or dopamine function.

Reviewed by eLife

Modeled grid cells aligned by a flexible attractor

1. Sabrina Benas
2. Ximena Fernandez
3. Emilio Kropff

• Curated by eLife

  eLife assessment

  In this valuable study, the authors use a computational model to investigate how recurrent connections influence the firing patterns of grid cells, which are thought to play a role in encoding an animal's position in space. The work suggests that a one-dimensional network architecture may be sufficient to generate the hexagonal firing patterns of grid cells, a possible alternative to attractor models based on recurrent connectivity between grid cells. However, the support for this proposal was incomplete, as some conclusions for how well the model dynamics are necessary to generate features of grid cell organization were not well supported.

Reviewed by eLife

Spatial and temporal pattern of structure–function coupling of human brain connectome with development

1. Guozheng Feng
2. Yiwen Wang
3. Weijie Huang
4. Haojie Chen
5. Jian Cheng
6. Ni Shu

• Curated by eLife

  eLife assessment

  This study presents a useful exploration of the complex relationship between structure and function in the developing human brain using a large-scale imaging dataset from the Human Connectome Project in Development and gene expression profiles from the Allen Brain Atlas. The evidence supporting the claims of the authors is solid, although the inclusion of more systematic analyses of structural and functional connectivity with respect to myelin measures and oligodendrocyte-related genes, and also more details regarding the imaging analyses, cognitive scores, and design and validation strategies, would have strengthened the paper. The work will be of interest to developmental biologists and neuroscientists seeking to elucidate structure-function relationships in the human brain.

Reviewed by eLife

Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord

1. Bridget M Curran
2. Kelsey R Nickerson
3. Andrea R Yung
4. Lisa V Goodrich
5. Alexander Jaworski
6. Marc Tessier-Lavigne
7. Le Ma

• Curated by eLife

  eLife assessment

  This important study expands our understanding of the role of two axon guidance factors in a specific axon guidance decision. The strength of the study is the compelling axonal labeling and quantification, which allows the authors to establish precise consequences of the loss of each guidance factor or receptor.

Reviewed by eLife

A Connectome of the Male Drosophila Ventral Nerve Cord

1. Shin-ya Takemura
2. Kenneth J Hayworth
3. Gary B Huang
4. Michal Januszewski
5. Zhiyuan Lu
6. Elizabeth C Marin
7. Stephan Preibisch
8. C Shan Xu
9. John Bogovic
10. Andrew S Champion
11. Han SJ Cheong
12. Marta Costa
13. Katharina Eichler
14. William Katz
15. Christopher Knecht
16. Feng Li
17. Billy J Morris
18. Christopher Ordish
19. Patricia K Rivlin
20. Philipp Schlegel
21. Kazunori Shinomiya
22. Tomke Stürner
23. Ting Zhao
24. Griffin Badalamente
25. Dennis Bailey
26. Paul Brooks
27. Brandon S Canino
28. Jody Clements
29. Michael Cook
30. Octave Duclos
31. Christopher R Dunne
32. Kelli Fairbanks
33. Siqi Fang
34. Samantha Finley-May
35. Audrey Francis
36. Reed George
37. Marina Gkantia
38. Kyle Harrington
39. Gary Patrick Hopkins
40. Joseph Hsu
41. Philip M Hubbard
42. Alexandre Javier
43. Dagmar Kainmueller
44. Wyatt Korff
45. Julie Kovalyak
46. Dominik Krzemiński
47. Shirley A Lauchie
48. Alanna Lohff
49. Charli Maldonado
50. Emily A Manley
51. Caroline Mooney
52. Erika Neace
53. Matthew Nichols
54. Omotara Ogundeyi
55. Nneoma Okeoma
56. Tyler Paterson
57. Elliott Phillips
58. Emily M Phillips
59. Caitlin Ribeiro
60. Sean M Ryan
61. Jon Thomson Rymer
62. Anne K Scott
63. Ashley L Scott
64. David Shepherd
65. Aya Shinomiya
66. Claire Smith
67. Natalie Smith
68. Alia Suleiman
69. Satoko Takemura
70. Iris Talebi
71. Imaan FM Tamimi
72. Eric T Trautman
73. Lowell Umayam
74. John J Walsh
75. Tansy Yang
76. Gerald M Rubin
77. Louis K Scheffer
78. Jan Funke
79. Stephan Saalfeld
80. Harald F Hess
81. Stephen M Plaza
82. Gwyneth M Card
83. Gregory SXE Jefferis
84. Stuart Berg

• Curated by eLife

  eLife assessment

  This landmark paper introduces the generation and analysis of a connectome resource of the entire ventral nerve cord of a fruit fly which is one of the top model organisms to investigate how a nervous system forms and functions. The work introduces new and improved approaches - from tissue preparation to automated reconstruction - to generate a detailed connectome from a complex adult ventral nerve cord. This extensive new dataset provides cell type and lineage annotations, putative neurotransmitter expression information, and the potential to link to genetic driver lines, with compelling evidence to support the claims made.

Reviewed by eLife

An atlas of brain-bone sympathetic neural circuits in mice

1. Vitaly Ryu
2. Anisa Azatovna Gumerova
3. Ronit Witztum
4. Funda Korkmaz
5. Liam Cullen
6. Hasni Kannangara
7. Ofer Moldavski
8. Orly Barak
9. Daria Lizneva
10. Ki A Goosens
11. Sarah Stanley
12. Se-Min Kim
13. Tony Yuen
14. Mone Zaidi

• Curated by eLife

  eLife assessment

  This fundamental work advances our understanding of the central coding and control mechanisms regulating sympathetic nervous system efferent signals to bone. The evidence supporting the conclusion is mostly convincing, although the inclusion of higher resolution images for certain data and further discussions would strengthen the study. This paper holds potential interest for skeletal biologists and neuroscientists who study the brain-bone sympathetic neural circuits.

Reviewed by eLife

White matter structural bases for phase accuracy during tapping synchronization

1. Pamela Garcia-Saldivar
2. Cynthia de León
3. Felipe A Mendez Salcido
4. Luis Concha
5. Hugo Merchant

• Curated by eLife

  eLife assessment

  This paper is valuable in that it provides a critical missing link between measures of structural connectivity and rhythmic tapping abilities, pointing to some interesting possibilities for how tapping synchronization is carried out. The methodology and findings are solid, and of interest to those studying the neural mechanisms of timing.

Reviewed by eLife

Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus

1. Kevin P Koster
2. S Murray Sherman

• Curated by eLife

  eLife assessment

  This investigation marks an important advancement in our understanding of motor thalamus connectivity, illustrating a complex integration of inputs that reshapes previous models. The study utilizes compelling methodologies that expose a dynamic synaptic network, although the evidence of triple-input convergence on individual neurons and for multiple driver type inputs onto motor thalamic neurons remains incomplete. Despite this, the findings provide a persuasive rationale for revisiting our perceptions of the thalamic role in motor control, with a call for further studies to substantiate the breadth of these functional interactions.

Reviewed by eLife

BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity

1. Diana Legutko
2. Bożena Kuźniewska
3. Katarzyna Kalita
4. Ryohei Yasuda
5. Leszek Kaczmarek
6. Piotr Michaluk

Reviewed by Review Commons