Neuroscience

PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles

1. Lu Li
2. Yin Li
3. Caihong Huang
4. Wenjuan Hou
5. Zijian Lv
6. Lizi Zhang
7. Yishan Qu
8. Yahan Sun
9. Kaizhe Huang
10. Xiao Han
11. Zhixiong He
12. Fadao Tai

• Curated by eLife

  eLife assessment

  This important work provides insights into the neural mechanisms regulating specific parental behaviors. By identifying a key role for oxytocin synthesizing cells in the paraventricular nucleus of the hypothalamus and their projections to the medial prefrontal cortex in promoting pup care and inhibiting infanticide, this study advances our understanding of the neurobiological basis of these contrasting behaviors in male and female mandarin voles. The evidence supporting the authors' conclusions is solid, and this work should be of interest to researchers studying neuropeptide control of social behaviors in the brain.

Reviewed by eLife

Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback

1. Ilya A Rybak
2. Natalia A Shevtsova
3. Sergey N Markin
4. Boris I Prilutsky
5. Alain Frigon

• Curated by eLife

  eLife assessment

  This fundamental state-of-the-art modeling study explores neural mechanisms underlying walking control in cats, demonstrating the probability of three different states of operation of the spinal circuitry generating locomotion at different speeds. The authors' biophysical modeling sufficiently reproduces and provides explanations for experimental data on how the locomotor cycle and phase durations depend on treadmill walking speed and points to new principles of circuit functional architecture and operating regimes underlying how spinal circuits interact with supraspinal signals and limb sensory feedback signals to produce different locomotor behaviors at different speeds, which are major unresolved problems in the field. The modeling evidence is compelling, especially in advancing our understanding of locomotion control mechanisms and will interest neuroscientists studying the neural control of movement.

Reviewed by eLife

α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

1. Rixu Cong
2. Huiran Li
3. Hong Yang
4. Jing Gu
5. Shanshan Wang
6. Xiangyu Guan
7. Tangyunfei Su
8. Yunlin Zheng
9. Dianchun Wang
10. Xinran Chen
11. Lei Yang
12. Yun Stone Shi
13. Mengping Wei
14. Chen Zhang

• Curated by eLife

  eLife assessment

  This fundamental work demonstrates that ABHD6 regulates AMPAR gating kinetics in a TARP γ-2-dependent manner. The evidence in this study is compelling. This study will be of interest to readers in the field of synaptic transmission.

Reviewed by eLife

Modelling inflammation-induced peripheral sensitization in a dish—more complex than expected?

1. Yuening Li
2. Amy Lock
3. Laura Fedele
4. Irene Zebochin
5. Alba Sabate
6. Matthew Siddle
7. Silvia Cainarca
8. Pascal Röderer
9. Katharina Montag
10. Paola Tarroni
11. Oliver Brüstle
12. Tanya Shaw
13. Leonie Taams
14. Franziska Denk

Reviewed by Arcadia Science

Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

1. Jiwon Jeong
2. Kujin Kwon
3. Terezia Klaudia Geisseova
4. Jongbin Lee
5. Taejoon Kwon
6. Chunghun Lim

Reviewed by Review Commons

The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

1. Kathryn Branam
2. Joshua I Gold
3. Long Ding

• Curated by eLife

  eLife assessment

  The fundamental study by Ding and colleagues identifies subpopulations of neurons recorded in the monkey subthalamic nucleus (STN) with distinct activity profiles and causal contributions during perceptual decision-making. The combination of neuronal recording, microstimulation, and computational methods provides convincing evidence for a heterogenous neural population that could support multifaceted roles in decision formation. This study should be of wide interest to computational and experimental neuroscientists interested in cognitive function.

Reviewed by eLife

Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

1. Adlin Abramian
2. Rein I Hoogstraaten
3. Fiona H Murphy
4. Kathryn F McDaniel
5. Ruud F Toonen
6. Matthijs Verhage

• Curated by eLife

  eLife assessment

  This important study advances our understanding of the mechanisms of neuronal large dense-core vesicle (LDCV) secretion, which mediates neuropeptide and neurotrophin release. It describes a negative regulatory process involving the interaction of the Rab3-effector Rabphilin-3A with the SNARE fusion protein SNAP25, which limits LDCV secretion and neurite growth. The evidence in support of the authors' claims is generally convincing, but some conclusions, e.g regarding the role of Rabphilin-3A-controlled neurotrophin signaling in neurite growth, are incompletely supported. This study will be of interest to the fields of cell biology, cellular neuroscience, and neuroendocrinology.

Reviewed by eLife

Natural forgetting reversibly modulates engram expression

1. James D O'Leary
2. Rasmus Bruckner
3. Livia Autore
4. Tomás J Ryan

• Curated by eLife

  eLife assessment

  This is an important paper on the role of engrams and relevant conditions that influence memory and forgetting. The variety of methods used, namely, behavioural, labeling, interrogation, immunohistochemistry, microscopy, pharmacology, computational, are exemplary and provide convincing evidence for the role of engrams in the dentate gyrus in memory retrieval and forgetting. This examination will be of interest broadly across behavioural and neural science communities.

Reviewed by eLife

Multisensory integration operates on correlated input from unimodal transient channels

1. Cesare V Parise
2. Marc O Ernst

• Curated by eLife

  eLife assessment

  This important study evaluates a model for multisensory correlation detection, focusing on the detection of correlated transients in visual and auditory stimuli. Overall, the experimental design is sound and the evidence is compelling. The synergy between the experimental and theoretical aspects of the paper is strong, and the work will be of interest to both neuroscientists and psychologists working in the domain of sensory processing and perception.

Reviewed by eLife

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

1. Falko Fuhrmann
2. Felix C. Nebeling
3. Fabrizio Musacchio
4. Manuel Mittag
5. Stefanie Poll
6. Monika Müller
7. Eleonora Ambrad Giovannetti
8. Michael Maibach
9. Barbara Schaffran
10. Emily Burnside
11. Ivy Chi Wai Chan
12. Alex Simon Lagurin
13. Nicole Reichenbach
14. Sanjeev Kaushalya
15. Hans Fried
16. Stefan Linden
17. Gabor C. Petzold
18. Gaia Tavosanis
19. Frank Bradke
20. Martin Fuhrmann

Reviewed by Arcadia Science