Neuroscience

A brainstem circuit controls cough-like airway defensive behaviors in mice

1. Xiaoshan Xu
2. Xiupeng Nie
3. Weijia Zhang
4. He-Hai Jiang
5. Bingyi Liu
6. Yanyan Ren
7. Tingting Wang
8. Xiang Xu
9. Jing Yang
10. Fujun Luo

• Curated by eLife

  eLife Assessment

  This valuable study by Xu and colleagues investigates brainstem circuits mediating evoked respiratory reflexes that they define as cough-like in a freely behaving mouse model. They have applied multiple circuit mapping and manipulation approaches to suggest that the caudal spinal trigeminal nucleus (SP5C) nucleus can play a novel role in generating a reflex cough-like behavior in mice. The authors give incomplete evidence that the reflex behavior produced in their mouse model is definitively cough, limiting functional interpretation of the putative circuit identified and requiring more thorough experimental interrogation of the behavior studied.

Reviewed by eLife

Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo

1. Siân Wilson
2. Daan Christiaens
3. Hyukjin Yun
4. Alena Uus
5. Lucilio Cordero-Grande
6. Vyacheslav Karolis
7. Anthony Price
8. Maria Deprez
9. Jacques-Donald Tournier
10. Mary Rutherford
11. Ellen Grant
12. Joseph V Hajnal
13. A David Edwards
14. Tomoki Arichi
15. Jonathan O’Muircheartaigh
16. Kiho Im

• Curated by eLife

  eLife Assessment

  This study presents a valuable study of early brain development using advanced MRI methods. In particular, the study investigates the relationship between the maturation of diffusion MRI tissue properties and suggests that they may precede and guide the emergence of brain folding patterns. The data is solid, however, the evidence supporting the precedence of tissue changes over brain folding appears incomplete.

Reviewed by eLife

Nonlinear brain connectivity from neurons to networks: quantification, sources and localization

1. Giulio Tani Raffaelli
2. Stanislav Jiříček
3. Jaroslav Hlinka

Reviewed by PREreview

It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

1. Spencer S Abssy
2. Natalie R Osborne
3. Evgeny E Osokin
4. Rossi Tomin
5. Liat Honigman
6. James S Khan
7. Nathaniel W De Vera
8. Andrew Furman
9. Ali Mazaheri
10. David A Seminowicz
11. Massieh Moayedi

• Curated by eLife

  eLife Assessment

  Abssy et al. carried out a study to test the effects of repetitive peripheral magnetic stimulation (rPMS) on pain perception in an experimental pain model and concluded that the analgesic properties of rPMS could be largely attributed to its auditory component rather than peripheral nerve stimulation per se. While the study presents valuable data on the modulation of pain perception in response to the stimulation paradigms that were tested, several issues in the experimental design and interpretation of results render the evidence incomplete to support their main claims, which should therefore be revised. In that case, these results could be of interest to pain clinicians and researchers.

Reviewed by eLife

Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates

1. Karen A. Lindquist
2. Jennifer M. Mecklenburg
3. Anahit H. Hovhannisyan
4. Shivani B. Ruparel
5. RE-JOIN Consortium Investigators
6. Armen N. Akopian

Reviewed by preLights

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

1. Thomas Larrieu
2. Charline Carron
3. Fabio Grieco
4. Crystal Weber
5. Kyllian Ginggen
6. Aurélie Delacrétaz
7. Hector Gallart-Ayala
8. Mumeko Tsuda
9. Heather A. Cameron
10. Chin B. Eap
11. Julijana Ivanisevic
12. Pierre Magistretti
13. Ludovic Telley
14. Alexandre Dayer
15. Camille Piguet
16. Nicolas Toni

Reviewed by preLights

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner

1. Venneman Tom
2. Pieter Vanden Berghe

Reviewed by PREreview

Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors

1. Tianmu Zhang
2. Zekun Wu
3. Yutong Song
4. Wenjing Li
5. Yanying Sun
6. Xiaoli Zhang
7. Kyle Wong
8. Justine Schweizer
9. Khoi-Nguyen Ha Nguyen
10. Alex Kwan
11. Woo Jae Kim

Reviewed by Review Commons

Peptidergic neurons with extensive branching orchestrate the internal states and energy balance of male Drosophila melanogaster

1. Yutong Song
2. Tianmu Zhang
3. Xiaoli Zhang
4. Tae Hoon Ryu
5. Kyle Wong
6. Zekun Wu
7. Yanan Wei
8. Justine Schweizer
9. Khoi-Nguyen Ha Nguyen
10. Alex Kwan
11. Kweon Yu
12. Woo Jae Kim

Reviewed by Review Commons