Molecular Biology

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

1. Anshul Budhraja
2. Anubhav Basu
3. Atish Gheware
4. Dasari Abhilash
5. Seesandra Rajagopala
6. Suman Pakala
7. Madhuresh Sumit
8. Animesh Ray
9. Arulselvi Subramaniam
10. Purva Mathur
11. Aruna Nambirajan
12. Sachin Kumar
13. Ritu Gupta
14. Naveet Wig
15. Anjan Trikha
16. Randeep Guleria
17. Chitra Sarkar
18. Ishaan Gupta
19. Deepali Jain

Reviewed by ScreenIT

SARS-CoV-2 infection in free-ranging white-tailed deer ( Odocoileus virginianus )

1. Vanessa L. Hale
2. Patricia M. Dennis
3. Dillon S. McBride
4. Jaqueline M. Nolting
5. Christopher Madden
6. Devra Huey
7. Margot Ehrlich
8. Jennifer Grieser
9. Jenessa Winston
10. Dusty Lombardi
11. Stormy Gibson
12. Linda Saif
13. Mary L. Killian
14. Kristina Lantz
15. Rachel Tell
16. Mia Torchetti
17. Suelee Robbe-Austerman
18. Martha I. Nelson
19. Seth A. Faith
20. Andrew S. Bowman

Reviewed by ScreenIT, NCRC

RNA-Seq is not required to determine stable reference genes for qPCR normalization

1. Nirmal Kumar Sampathkumar
2. Venkat Krishnan Sundaram
3. Prakroothi S. Danthi
4. Rasha Barakat
5. Shiden Solomon
6. Mrityunjoy Mondal
7. Ivo Carre
8. Tatiana El Jalkh
9. Aïda Padilla-Ferrer
10. Julien Grenier
11. Charbel Massaad
12. Jacqueline C. Mitchell

Reviewed by Review Commons

Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

1. Fernando Rodrigo Rosas Bringas
2. Sonia Stinus
3. Pien de Zoeten
4. Marita Cohn
5. Michael Chang

• Curated by eLife

  Evaluation Summary:

  This study investigates the tolerance to change in the sequence of telomere repeats, by analyzing a strain expressing mutant TLC1, the RNA component of the telomerase. The authors conclude that Rif2 protects telomere ends in the absence of RAP1 by inhibiting MRX and promoting Rad51-dependent homologous recombination to maintain telomere homeostasis. The study clarifies the role of Rif2 in telomere homeostais and describes how cells can extend telomeres and control senescence in the absence of Rap1 binding to telomeres. The possibility of coping with telomere sequence modification through flexibility and redundancy of capping proteins is of general interest in terms of telomere evolution.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Exploring functional protein covariation across single cells using nPOP

1. Andrew Leduc
2. R. Gray Huffman
3. Joshua Cantlon
4. Saad Khan
5. Nikolai Slavov

Reviewed by ASAPbio crowd review

A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies

1. Santhik Subhasingh Lupitha
2. Pramod Darvin
3. Aneesh Chandrasekharan
4. Shankara Narayanan Varadarajan
5. Soumya Jaya Divakaran
6. Sreekumar Easwaran
7. Shijulal Nelson-Sathi
8. Perunthottathu K Umasankar
9. Sara Jones
10. Iype Joseph
11. Madhavan Radhakrishna Pillai
12. Thankayyan Retnabai Santhoshkumar

Reviewed by ScreenIT

SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

1. Yotam Menuchin-Lasowski
2. André Schreiber
3. Aarón Lecanda
4. Angeles Mecate-Zambrano
5. Linda Brunotte
6. Olympia E. Psathaki
7. Stephan Ludwig
8. Thomas Rauen
9. Hans R. Schöler

Reviewed by ScreenIT

Secondary Structure of Subgenomic RNA M of SARS-CoV-2

1. Marta Soszynska-Jozwiak
2. Agnieszka Ruszkowska
3. Ryszard Kierzek
4. Collin A. O’Leary
5. Walter N. Moss
6. Elzbieta Kierzek

Reviewed by ScreenIT

Highly resolved spatial transcriptomics for detection of rare events in cells

1. Silvia Groiss
2. Daniela Pabst
3. Cynthia Faber
4. Andreas Meier
5. Annette Bogdoll
6. Conny Unger
7. Benedikt Nilges
8. Sascha Strauss
9. Esther Föderl-Höbenreich
10. Melina Hardt
11. Andreas Geipel
12. Frank Reinecke
13. Christian Korfhage
14. Kurt Zatloukal

Reviewed by ScreenIT

A bacteria-based assay to study SARS-CoV-2 protein-protein interactions

1. Benjamin L. Springstein
2. Padraig Deighan
3. Grzegorz Grabe
4. Ann Hochschild

Reviewed by ScreenIT