1. RNA-Seq is not required to determine stable reference genes for qPCR normalization

    This article has 12 authors:
    1. Nirmal Kumar Sampathkumar
    2. Venkat Krishnan Sundaram
    3. Prakroothi S. Danthi
    4. Rasha Barakat
    5. Shiden Solomon
    6. Mrityunjoy Mondal
    7. Ivo Carre
    8. Tatiana El Jalkh
    9. Aïda Padilla-Ferrer
    10. Julien Grenier
    11. Charbel Massaad
    12. Jacqueline C. Mitchell

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

    This article has 5 authors:
    1. Fernando Rodrigo Rosas Bringas
    2. Sonia Stinus
    3. Pien de Zoeten
    4. Marita Cohn
    5. Michael Chang
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This study investigates the tolerance to change in the sequence of telomere repeats, by analyzing a strain expressing mutant TLC1, the RNA component of the telomerase. The authors conclude that Rif2 protects telomere ends in the absence of RAP1 by inhibiting MRX and promoting Rad51-dependent homologous recombination to maintain telomere homeostasis. The study clarifies the role of Rif2 in telomere homeostais and describes how cells can extend telomeres and control senescence in the absence of Rap1 binding to telomeres. The possibility of coping with telomere sequence modification through flexibility and redundancy of capping proteins is of general interest in terms of telomere evolution.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Exploring functional protein covariation across single cells using nPOP

    This article has 5 authors:
    1. Andrew Leduc
    2. R. Gray Huffman
    3. Joshua Cantlon
    4. Saad Khan
    5. Nikolai Slavov

    Reviewed by ASAPbio crowd review

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies

    This article has 12 authors:
    1. Santhik Subhasingh Lupitha
    2. Pramod Darvin
    3. Aneesh Chandrasekharan
    4. Shankara Narayanan Varadarajan
    5. Soumya Jaya Divakaran
    6. Sreekumar Easwaran
    7. Shijulal Nelson-Sathi
    8. Perunthottathu K Umasankar
    9. Sara Jones
    10. Iype Joseph
    11. Madhavan Radhakrishna Pillai
    12. Thankayyan Retnabai Santhoshkumar

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

    This article has 9 authors:
    1. Yotam Menuchin-Lasowski
    2. André Schreiber
    3. Aarón Lecanda
    4. Angeles Mecate-Zambrano
    5. Linda Brunotte
    6. Olympia E. Psathaki
    7. Stephan Ludwig
    8. Thomas Rauen
    9. Hans R. Schöler

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Secondary Structure of Subgenomic RNA M of SARS-CoV-2

    This article has 6 authors:
    1. Marta Soszynska-Jozwiak
    2. Agnieszka Ruszkowska
    3. Ryszard Kierzek
    4. Collin A. O’Leary
    5. Walter N. Moss
    6. Elzbieta Kierzek

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Highly resolved spatial transcriptomics for detection of rare events in cells

    This article has 14 authors:
    1. Silvia Groiss
    2. Daniela Pabst
    3. Cynthia Faber
    4. Andreas Meier
    5. Annette Bogdoll
    6. Conny Unger
    7. Benedikt Nilges
    8. Sascha Strauss
    9. Esther Föderl-Höbenreich
    10. Melina Hardt
    11. Andreas Geipel
    12. Frank Reinecke
    13. Christian Korfhage
    14. Kurt Zatloukal

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. A bacteria-based assay to study SARS-CoV-2 protein-protein interactions

    This article has 4 authors:
    1. Benjamin L. Springstein
    2. Padraig Deighan
    3. Grzegorz Grabe
    4. Ann Hochschild

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. ACE2 pathway regulates thermogenesis and energy metabolism

    This article has 11 authors:
    1. Xi Cao
    2. Ting-Ting Shi
    3. Chuan-Hai Zhang
    4. Wan-Zhu Jin
    5. Li-Ni Song
    6. Yi-Chen Zhang
    7. Jing-Yi Liu
    8. Fang-Yuan Yang
    9. Charles N Rotimi
    10. Aimin Xu
    11. Jin-Kui Yang
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      With a series of elegant experiments, the authors have shown that the renin-angiotensin system (RAS) plays a critical role in thermogenesis. Involvement of brown fat and mitochondrial chain open new scenarios that may be helpful to define new target pathways for the treatment of obesity and diabetes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity

    This article has 11 authors:
    1. Ahmed A. Ramadan
    2. Karthick Mayilsamy
    3. Andrew R. McGill
    4. Anandita Ghosh
    5. Marc A. Giulianotti
    6. Haley M. Donow
    7. Shyam S. Mohapatra
    8. Subhra Mohapatra
    9. Bala Chandran
    10. Robert J. Deschenes
    11. Arunava Roy

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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