Molecular Biology

Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections

1. Vanessa Monteil
2. Devignot Stephanie
3. Jonas Klingström
4. Charlotte Thålin
5. Max J. Kellner
6. Wanda Christ
7. Sebastian Havervall
8. Stefan Mereiter
9. Sylvia Knapp
10. Nuria Montserrat
11. Benedict Braunsfeld
12. Ivona Kozieradzki
13. Omar Hasan Ali
14. Astrid Hagelkruys
15. Johannes Stadlmann
16. Chris Oostenbrink
17. Gerald Wirnsberger
18. Josef M. Penninger
19. Ali Mirazimi

Reviewed by ScreenIT

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

1. Emanuel Wyler
2. Julia M. Adler
3. Kathrin Eschke
4. G. Teixeira Alves
5. Stefan Peidli
6. Fabian Pott
7. Julia Kazmierski
8. Laura Michalick
9. Olivia Kershaw
10. Judith Bushe
11. Sandro Andreotti
12. Peter Pennitz
13. Azza Abdelgawad
14. Dylan Postmus
15. Christine Goffinet
16. Jakob Kreye
17. S Momsen Reincke
18. Harald Prüss
19. Nils Blüthgen
20. Achim D. Gruber
21. Wolfgang M. Kuebler
22. Martin Witzenrath
23. Markus Landthaler
24. Geraldine Nouailles
25. Jakob Trimpert

Reviewed by ScreenIT

Transcriptomic responses of the human kidney to acute injury at single cell resolution

1. Christian Hinze
2. Christine Kocks
3. Janna Leiz
4. Nikos Karaiskos
5. Anastasiya Boltengagen
6. Christopher Mark Skopnik
7. Jan Klocke
8. Jan-Hendrik Hardenberg
9. Helena Stockmann
10. Inka Gotthardt
11. Benedikt Obermayer
12. Laleh Haghverdi
13. Emanuel Wyler
14. Markus Landthaler
15. Sebastian Bachmann
16. Andreas C. Hocke
17. Victor Corman
18. Jonas Busch
19. Wolfgang Schneider
20. Nina Himmerkus
21. Markus Bleich
22. Kai-Uwe Eckardt
23. Philipp Enghard
24. Nikolaus Rajewsky
25. Kai M. Schmidt-Ott

Reviewed by ScreenIT

Compared with SARS-CoV2 wild type’s spike protein, the SARS-CoV2 omicron’s receptor binding motif has adopted a more SARS-CoV1 and/or bat/civet-like structure

1. Michael O. Glocker
2. Kwabena F.M. Opuni
3. Hans-Juergen Thiesen

Reviewed by ScreenIT

RBBP6 activates the pre-mRNA 3′ end processing machinery in humans

1. Vytaute Boreikaite
2. Thomas S. Elliott
3. Jason W. Chin
4. Lori A. Passmore

Reviewed by ASAPbio crowd review

Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

1. Érika Pereira Zambalde
2. Isadora Carolina Betim Pavan
3. Mariana Camargo Silva Mancini
4. Matheus Brandemarte Severino
5. Orlando Bonito Scudero
6. Ana Paula Morelli
7. Mariene Ribeiro Amorim
8. Karina Bispo dos Santos
9. Mariana Marcela Góis
10. Daniel Augusto de Toledo-Teixeira
11. Pierina Lorencini Parise
12. Thais Mauad
13. Marisa Dolhnikoff
14. Paulo Hilário Nascimento Saldiva
15. Henrique Marques-Souza
16. José Luiz Proenca-Modena
17. Armando Morais Ventura
18. Fernando Moreira Simabuco

Reviewed by ScreenIT

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

1. Tiziana Ginex
2. Clara Marco-Marín
3. Miłosz Wieczór
4. Carlos P. Mata
5. James Krieger
6. Paula Ruiz-Rodriguez
7. Maria Luisa López-Redondo
8. Clara Francés-Gómez
9. Roberto Melero
10. Carlos Óscar Sánchez-Sorzano
11. Marta Martínez
12. Nadine Gougeard
13. Alicia Forcada-Nadal
14. Sara Zamora-Caballero
15. Roberto Gozalbo-Rovira
16. Carla Sanz-Frasquet
17. Rocío Arranz
18. Jeronimo Bravo
19. Vicente Rubio
20. Alberto Marina
21. The IBV-Covid19-Pipeline
22. Ron Geller
23. Iñaki Comas
24. Carmen Gil
25. Mireia Coscolla
26. Modesto Orozco
27. José Luis Llácer
28. Jose-Maria Carazo

Reviewed by ScreenIT

Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

1. Yo Han Lee
2. Hyun-Jun Jang
3. Sounkou Kim
4. Sun Sil Choi
5. Keon Woo Khim
6. Hye-jin Eom
7. Jimin Hyun
8. Kyeong Jin Shin
9. Young Chan Chae
10. Hongtae Kim
11. Jiyoung Park
12. Neung Hwa Park
13. Chang-Yun Woo
14. Chung Hwan Hong
15. Eun Hee Koh
16. Dougu Nam
17. Jang Hyun Choi

• Curated by eLife

  Evaluation Summary:

  The manuscript by Lee et al. provides mechanistic insight into the regulatory role of micro RNAs in modulating nuclear receptor expression and function. This is likely to have a high impact on the field as nuclear receptor regulation of metabolic disease is well established, however, the molecular mechanisms governing this process still remains unknown largely. Lee et al.'s manuscript provides a molecular target (miR-20b) that holds therapeutic potential in improving hepatic steatosis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Critical Negatively Charged Residues Are Important for the Activity of SARS-CoV-1 and SARS-CoV-2 Fusion Peptides

1. Alex L. Lai
2. Jack H. Freed

Reviewed by ScreenIT

Predictions of the SARS-CoV-2 Omicron Variant (B.1.1.529) Spike Protein Receptor-Binding Domain Structure and Neutralizing Antibody Interactions

1. Colby T. Ford
2. Denis Jacob Machado
3. Daniel A. Janies

Reviewed by ScreenIT