1. An entropic safety catch controls hepatitis C virus entry and antibody resistance

    This article has 16 authors:
    1. Lenka Stejskal
    2. Mphatso D Kalemera
    3. Charlotte B Lewis
    4. Machaela Palor
    5. Lucas Walker
    6. Tina Daviter
    7. William D Lees
    8. David S Moss
    9. Myrto Kremyda-Vlachou
    10. Zisis Kozlakidis
    11. Giulia Gallo
    12. Dalan Bailey
    13. William Rosenberg
    14. Christopher JR Illingworth
    15. Adrian J Shepherd
    16. Joe Grove
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      HCV is unique in its glycoprotein structure, complex receptor usage and its unusual persistence for a (+)RNA virus. This is a well done study that explains a number of observations regarding receptor usage and how HCV may evade antibody control via HVR1 due to its disordered nature, enable mutation to continually evade antibody responses. This manuscript should be of substantial interest to those in the fields of virus entry, vaccination against human viruses, and the study of how intrinsically disordered regions can play regulatory roles.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. SARS- CoV-2 viroporins: A multi-omics insight from nucleotides to amino acids

    This article has 4 authors:
    1. Manish Sarkar
    2. Paul Etheimer
    3. Victor Hannothiaux
    4. Soham Saha

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Analysis of the upper respiratory tract microbiota in mild and severe COVID-19 patients

    This article has 57 authors:
    1. V. Babenko
    2. R. Bakhtyev
    3. V. Baklaushev
    4. L. Balykova
    5. P. Bashkirov
    6. J. Bespyatykh
    7. A. Blagonravova
    8. D. Boldyreva
    9. D. Fedorov
    10. I. Gafurov
    11. R. Gaifullina
    12. J. Galeeva
    13. E. Galova
    14. A. Gospodaryk
    15. E. Ilina
    16. K. Ivanov
    17. D. Kharlampieva
    18. P. Khromova
    19. K. Klimina
    20. K. Kolontarev
    21. N. Kolyshkina
    22. A. Koritsky
    23. V. Kuropatkin
    24. V. Lazarev
    25. A. Manolov
    26. V. Manuvera
    27. D. Matyushkina
    28. M. Morozov
    29. E. Moskaleva
    30. V. Musarova
    31. O. Ogarkov
    32. E. Orlova
    33. A. Pavlenko
    34. A. Petrova
    35. N. Pozhenko
    36. D. Pushkar
    37. A. Rumyantsev
    38. S. Rumyantsev
    39. V. Rumyantsev
    40. L. Rychkova
    41. A. Samoilov
    42. I. Shirokova
    43. V. Sinkov
    44. S. Solovieva
    45. E. Starikova
    46. P. Tikhonova
    47. G. Trifonova
    48. A. Troitsky
    49. A. Tulichev
    50. Y. Udalov
    51. A. Varizhuk
    52. A. Vasiliev
    53. R. Vereshchagin
    54. V. Veselovsky
    55. A. Volnukhin
    56. G. Yusubalieva
    57. V. Govorun

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

    This article has 11 authors:
    1. Danielle G. May
    2. Laura Martin-Sancho
    3. Valesca Anschau
    4. Sophie Liu
    5. Rachel J. Chrisopulos
    6. Kelsey L. Scott
    7. Charles T. Halfmann
    8. Ramon Díaz Peña
    9. Dexter Pratt
    10. Alexandre R. Campos
    11. Kyle J. Roux

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

    This article has 9 authors:
    1. Sarah G Swygert
    2. Dejun Lin
    3. Stephanie Portillo-Ledesma
    4. Po-Yen Lin
    5. Dakota R Hunt
    6. Cheng-Fu Kao
    7. Tamar Schlick
    8. William S Noble
    9. Toshio Tsukiyama
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This work characterizes chromatin compaction in quiescent yeast cells and its role in the repression of gene expression. The authors' findings that chromatin compaction via heterogeneous interactions between nucleosomes directly contributes to transcriptional repression provides a useful conceptual paradigm for studies of quiescence in other organisms.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    This article has 8 authors:
    1. Laura Arribas-Hernández
    2. Sarah Rennie
    3. Tino Köster
    4. Carlotta Porcelli
    5. Martin Lewinski
    6. Dorothee Staiger
    7. Robin Andersson
    8. Peter Brodersen
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Gene regulation triggered by recognising N6-methyladenosine (m6A) by RNA-binding proteins emerged as a fundamental process for development and adaptation in most eukaryotes. This paper is of interest to scientists within the field of post-transcriptional gene regulation and RNA biology. In a deep and thorough analysis, the authors resolved previously contradictory reports of sequence motifs associated with methylation sites in messenger RNAs and shed light on the proteins that recognise this modification.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

      This manuscript was co-submitted with: https://www.biorxiv.org/content/10.1101/2021.08.01.454660v1

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

    This article has 8 authors:
    1. Laura Arribas-Hernández
    2. Sarah Rennie
    3. Michael Schon
    4. Carlotta Porcelli
    5. Balaji Enugutti
    6. Robin Andersson
    7. Michael D Nodine
    8. Peter Brodersen
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Post-transcriptional gene regulation mediated by YTH proteins that bind N6-methyladenosine (m6A) in mRNA is a pathway that has emerged of importance in eukaryotic biology. This paper focuses on two evolutionarily close proteins of this family, ETC2 and ETC3 to find redundant, specific and divergent functions. The authors addressed previously contradictory reports regarding the subcellular location of these proteins. The paper is of general interest to scientists within the field of post-transcriptional gene regulation and RNA biology and is not limited to the plant research community. This will advance our understanding of mRNA methylation and its role in plant biology.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

      This manuscript was co-submitted with: https://www.biorxiv.org/content/10.1101/2021.04.18.440342v2

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

    This article has 9 authors:
    1. Lucija Bujanic
    2. Olga Shevchuk
    3. Nicolai von Kügelgen
    4. Anna Kalinina
    5. Katarzyna Ludwik
    6. David Koppstein
    7. Nadja Zerna
    8. Albert Sickmann
    9. Marina Chekulaeva

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    This article has 13 authors:
    1. Eriko Matsuura-Suzuki
    2. Tadahiro Shimazu
    3. Mari Takahashi
    4. Kaoru Kotoshiba
    5. Takehiro Suzuki
    6. Kazuhiro Kashiwagi
    7. Yoshihiro Sohtome
    8. Mai Akakabe
    9. Mikiko Sodeoka
    10. Naoshi Dohmae
    11. Takuhiro Ito
    12. Yoichi Shinkai
    13. Shintaro Iwasaki
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This work examines how METTLL18-mediated RPL3 histidine methylation on 245 position regulates translation elongation and protects cells from cellular aggregation of Tyr-rich proteins. The study hints at the existence of a "ribosome code" and how posttranslational modification of ribosomal proteins could affect translation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

    This article has 23 authors:
    1. Gerald Wirnsberger
    2. Vanessa Monteil
    3. Brett Eaton
    4. Elena Postnikova
    5. Michael Murphy
    6. Benedict Braunsfeld
    7. Ian Crozier
    8. Franz Kricek
    9. Janine Niederhöfer
    10. Alice Schwarzböck
    11. Helene Breid
    12. Anna Sanchez Jimenez
    13. Agnes Bugajska-Schretter
    14. Alexander Dohnal
    15. Christine Ruf
    16. Romana Gugenberger
    17. Astrid Hagelkruys
    18. Nuria Montserrat
    19. Michael R. Holbrook
    20. Chris Oostenbrink
    21. Robert H. Shoemaker
    22. Ali Mirazimi
    23. Josef M. Penninger

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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