Molecular Biology

Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

1. Érika Pereira Zambalde
2. Isadora Carolina Betim Pavan
3. Mariana Camargo Silva Mancini
4. Matheus Brandemarte Severino
5. Orlando Bonito Scudero
6. Ana Paula Morelli
7. Mariene Ribeiro Amorim
8. Karina Bispo dos Santos
9. Mariana Marcela Góis
10. Daniel Augusto de Toledo-Teixeira
11. Pierina Lorencini Parise
12. Thais Mauad
13. Marisa Dolhnikoff
14. Paulo Hilário Nascimento Saldiva
15. Henrique Marques-Souza
16. José Luiz Proenca-Modena
17. Armando Morais Ventura
18. Fernando Moreira Simabuco

Reviewed by ScreenIT

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

1. Tiziana Ginex
2. Clara Marco-Marín
3. Miłosz Wieczór
4. Carlos P. Mata
5. James Krieger
6. Paula Ruiz-Rodriguez
7. Maria Luisa López-Redondo
8. Clara Francés-Gómez
9. Roberto Melero
10. Carlos Óscar Sánchez-Sorzano
11. Marta Martínez
12. Nadine Gougeard
13. Alicia Forcada-Nadal
14. Sara Zamora-Caballero
15. Roberto Gozalbo-Rovira
16. Carla Sanz-Frasquet
17. Rocío Arranz
18. Jeronimo Bravo
19. Vicente Rubio
20. Alberto Marina
21. The IBV-Covid19-Pipeline
22. Ron Geller
23. Iñaki Comas
24. Carmen Gil
25. Mireia Coscolla
26. Modesto Orozco
27. José Luis Llácer
28. Jose-Maria Carazo

Reviewed by ScreenIT

Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

1. Yo Han Lee
2. Hyun-Jun Jang
3. Sounkou Kim
4. Sun Sil Choi
5. Keon Woo Khim
6. Hye-jin Eom
7. Jimin Hyun
8. Kyeong Jin Shin
9. Young Chan Chae
10. Hongtae Kim
11. Jiyoung Park
12. Neung Hwa Park
13. Chang-Yun Woo
14. Chung Hwan Hong
15. Eun Hee Koh
16. Dougu Nam
17. Jang Hyun Choi

• Curated by eLife

  Evaluation Summary:

  The manuscript by Lee et al. provides mechanistic insight into the regulatory role of micro RNAs in modulating nuclear receptor expression and function. This is likely to have a high impact on the field as nuclear receptor regulation of metabolic disease is well established, however, the molecular mechanisms governing this process still remains unknown largely. Lee et al.'s manuscript provides a molecular target (miR-20b) that holds therapeutic potential in improving hepatic steatosis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Critical Negatively Charged Residues Are Important for the Activity of SARS-CoV-1 and SARS-CoV-2 Fusion Peptides

1. Alex L. Lai
2. Jack H. Freed

Reviewed by ScreenIT

Predictions of the SARS-CoV-2 Omicron Variant (B.1.1.529) Spike Protein Receptor-Binding Domain Structure and Neutralizing Antibody Interactions

1. Colby T. Ford
2. Denis Jacob Machado
3. Daniel A. Janies

Reviewed by ScreenIT

SARS-CoV-2 Delta and delta derivatives impact on neutralization of Covishield recipient sera

1. Rima R. Sahay
2. Deepak Y. Patil
3. Gajanan N. Sapkal
4. Gururaj R. Deshpande
5. Anita M. Shete
6. Dimpal A. Nyayanit
7. Sanjay Kumar
8. Pragya D. Yadav

Reviewed by ScreenIT

Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers

1. Johannes N. Wibisana
2. Takehiko Inaba
3. Hisaaki Shinohara
4. Noriko Yumoto
5. Tetsutaro Hayashi
6. Mana Umeda
7. Masashi Ebisawa
8. Itoshi Nikaido
9. Yasushi Sako
10. Mariko Okada

Reviewed by Review Commons

Case Study of High-Throughput Drug Screening and Remote Data Collection for SARS-CoV-2 Main Protease by Using Serial Femtosecond X-ray Crystallography

1. Omur Guven
2. Mehmet Gul
3. Esra Ayan
4. J Austin Johnson
5. Baris Cakilkaya
6. Gozde Usta
7. Fatma Betul Ertem
8. Nurettin Tokay
9. Busra Yuksel
10. Oktay Gocenler
11. Cengizhan Buyukdag
12. Sabine Botha
13. Gihan Ketawala
14. Zhen Su
15. Brandon Hayes
16. Frederic Poitevin
17. Alexander Batyuk
18. Chun Hong Yoon
19. Christopher Kupitz
20. Serdar Durdagi
21. Raymond G. Sierra
22. Hasan DeMirci

Reviewed by ScreenIT

Protective Immunity of the Primary SARS-CoV-2 Infection Reduces Disease Severity Post Re-Infection with Delta Variants in Syrian Hamsters

1. Sreelekshmy Mohandas
2. Pragya D. Yadav
3. Anita Shete
4. Dimpal Nyayanit
5. Rajlaxmi Jain
6. Gajanan Sapkal
7. Chandrashekhar Mote

Reviewed by ScreenIT

DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

1. Faith C Fowler
2. Bo-Ruei Chen
3. Nicholas Zolnerowich
4. Wei Wu
5. Raphael Pavani
6. Jacob Paiano
7. Chelsea Peart
8. Zulong Chen
9. André Nussenzweig
10. Barry P Sleckman
11. Jessica K Tyler

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest for scientists interested in cell cycle, DNA repair, and genome stability reporting the unexpected discovery that the DNA-dependent protein kinase (DNA-PK) is required for DSB resection in G0 cells, whereas it is known and confirmed here that it inhibits resection in G1 and G2 cells. This finding has important implications for the clinical application of DNA-PK-targeted inhibitors. The data are of high quality and derive from two independent cell lines, genetic requirements were mostly established by gene knockouts, and the latest genome-wide sequencing techniques were applied to measure resection tracts. The key claims of the manuscript are supported by the data presented by the authors; however, further validations are needed to strengthen the quality and impact of the paper.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife