1. Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation

    This article has 9 authors:
    1. Yang S Chen
    2. Wanfu Hou
    3. Sharon Tracy
    4. Alex T Harvey
    5. Vince Harjono
    6. Fan Xu
    7. James J Moresco
    8. John R Yates
    9. Brian M Zid

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

    This article has 15 authors:
    1. Sandhya Balasubramanian
    2. Matteo Andreani
    3. Júlia Goncalves Andrade
    4. Tannishtha Saha
    5. Devakumar Sundaravinayagam
    6. Javier Garzón
    7. Wenzhu Zhang
    8. Oliver Popp
    9. Shin-ichiro Hiraga
    10. Ali Rahjouei
    11. Daniel B Rosen
    12. Philipp Mertins
    13. Brian T Chait
    14. Anne D Donaldson
    15. Michela Di Virgilio
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      RIF1 is a protein of the DNA damage response with key roles on genome integrity: it prevents DSB resection and hence accurate HR repair, whilst protecting stalled forks from degradation under replication stress conditions. The authors' main finding is the identification of 3 residues in RIF1 protein, that can be phosphorylated in ATM/ATR-dependent manner. However, this phosphorylation is dispensable for the ability of RIF1 to limit double-strand break resection, but is required to counteract the degradation of stalled replication intermediates mediated by the DNA2 nuclease. Therefore, the manuscript suggests that the three sites can provide a potential switch between the two functions of RIF1. These findings will spark the interest of readers working in the DNA replication and repair fields. However, the actual mechanism by which blocking RIF1 phosphorylation prevents RIF1 function at replication forks still needs to be determined.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

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  3. Sequence-assignment validation in cryo-EM models with checkMySequence

    This article has 1 author:
    1. Grzegorz Chojnowski

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections

    This article has 19 authors:
    1. Vanessa Monteil
    2. Devignot Stephanie
    3. Jonas Klingström
    4. Charlotte Thålin
    5. Max J. Kellner
    6. Wanda Christ
    7. Sebastian Havervall
    8. Stefan Mereiter
    9. Sylvia Knapp
    10. Nuria Montserrat
    11. Benedict Braunsfeld
    12. Ivona Kozieradzki
    13. Omar Hasan Ali
    14. Astrid Hagelkruys
    15. Johannes Stadlmann
    16. Chris Oostenbrink
    17. Gerald Wirnsberger
    18. Josef M. Penninger
    19. Ali Mirazimi

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

    This article has 25 authors:
    1. Emanuel Wyler
    2. Julia M. Adler
    3. Kathrin Eschke
    4. G. Teixeira Alves
    5. Stefan Peidli
    6. Fabian Pott
    7. Julia Kazmierski
    8. Laura Michalick
    9. Olivia Kershaw
    10. Judith Bushe
    11. Sandro Andreotti
    12. Peter Pennitz
    13. Azza Abdelgawad
    14. Dylan Postmus
    15. Christine Goffinet
    16. Jakob Kreye
    17. S Momsen Reincke
    18. Harald Prüss
    19. Nils Blüthgen
    20. Achim D. Gruber
    21. Wolfgang M. Kuebler
    22. Martin Witzenrath
    23. Markus Landthaler
    24. Geraldine Nouailles
    25. Jakob Trimpert

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Transcriptomic responses of the human kidney to acute injury at single cell resolution

    This article has 25 authors:
    1. Christian Hinze
    2. Christine Kocks
    3. Janna Leiz
    4. Nikos Karaiskos
    5. Anastasiya Boltengagen
    6. Christopher Mark Skopnik
    7. Jan Klocke
    8. Jan-Hendrik Hardenberg
    9. Helena Stockmann
    10. Inka Gotthardt
    11. Benedikt Obermayer
    12. Laleh Haghverdi
    13. Emanuel Wyler
    14. Markus Landthaler
    15. Sebastian Bachmann
    16. Andreas C. Hocke
    17. Victor Corman
    18. Jonas Busch
    19. Wolfgang Schneider
    20. Nina Himmerkus
    21. Markus Bleich
    22. Kai-Uwe Eckardt
    23. Philipp Enghard
    24. Nikolaus Rajewsky
    25. Kai M. Schmidt-Ott

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Compared with SARS-CoV2 wild type’s spike protein, the SARS-CoV2 omicron’s receptor binding motif has adopted a more SARS-CoV1 and/or bat/civet-like structure

    This article has 3 authors:
    1. Michael O. Glocker
    2. Kwabena F.M. Opuni
    3. Hans-Juergen Thiesen

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. RBBP6 activates the pre-mRNA 3′ end processing machinery in humans

    This article has 4 authors:
    1. Vytaute Boreikaite
    2. Thomas S. Elliott
    3. Jason W. Chin
    4. Lori A. Passmore

    Reviewed by ASAPbio crowd review

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

    This article has 18 authors:
    1. Érika Pereira Zambalde
    2. Isadora Carolina Betim Pavan
    3. Mariana Camargo Silva Mancini
    4. Matheus Brandemarte Severino
    5. Orlando Bonito Scudero
    6. Ana Paula Morelli
    7. Mariene Ribeiro Amorim
    8. Karina Bispo dos Santos
    9. Mariana Marcela Góis
    10. Daniel Augusto de Toledo-Teixeira
    11. Pierina Lorencini Parise
    12. Thais Mauad
    13. Marisa Dolhnikoff
    14. Paulo Hilário Nascimento Saldiva
    15. Henrique Marques-Souza
    16. José Luiz Proenca-Modena
    17. Armando Morais Ventura
    18. Fernando Moreira Simabuco

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

    This article has 28 authors:
    1. Tiziana Ginex
    2. Clara Marco-Marín
    3. Miłosz Wieczór
    4. Carlos P. Mata
    5. James Krieger
    6. Paula Ruiz-Rodriguez
    7. Maria Luisa López-Redondo
    8. Clara Francés-Gómez
    9. Roberto Melero
    10. Carlos Óscar Sánchez-Sorzano
    11. Marta Martínez
    12. Nadine Gougeard
    13. Alicia Forcada-Nadal
    14. Sara Zamora-Caballero
    15. Roberto Gozalbo-Rovira
    16. Carla Sanz-Frasquet
    17. Rocío Arranz
    18. Jeronimo Bravo
    19. Vicente Rubio
    20. Alberto Marina
    21. The IBV-Covid19-Pipeline
    22. Ron Geller
    23. Iñaki Comas
    24. Carmen Gil
    25. Mireia Coscolla
    26. Modesto Orozco
    27. José Luis Llácer
    28. Jose-Maria Carazo

    Reviewed by ScreenIT

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