1. Translational buffering by ribosome stalling in upstream open reading frames

    This article has 4 authors:
    1. Ty A. Bottorff
    2. Heungwon Park
    3. Adam P. Geballe
    4. Arvind Rasi Subramaniam

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Drosophila cap-binding protein eiF4EHP promotes translation via a 3’UTR-dependent mechanism under hypoxia and contributes to fruit fly adaptation to oxygen variations

    This article has 14 authors:
    1. Manfei Liang
    2. Clara Hody
    3. Vanessa Yammine
    4. Romuald Soin
    5. Yuqiu Sun
    6. Xing Lin
    7. Xiaoying Tian
    8. Romane Meurs
    9. Camille Perdrau
    10. Nadège Delacourt
    11. Fabienne Andris
    12. Louise Conrard
    13. Véronique Kruys
    14. Cyril Gueydan

    Reviewed by Review Commons

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Nucleotide-level linkage of transcriptional elongation and polyadenylation

    This article has 6 authors:
    1. Joseph V Geisberg
    2. Zarmik Moqtaderi
    3. Nova Fong
    4. Benjamin Erickson
    5. David L Bentley
    6. Kevin Struhl
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Giesberg and colleagues provide evidence both in yeast and human cells that fast elongation speeds of RNA polymerases result in a "downstream-shifted" poly(A) profile while the opposite is true for slower speeds of elongating polymerases. GC content of sequences downstream of poly(A) clusters influences the cluster profiles by affecting elongation and thus allowing more time for the 3'-cleavage complex to find the poly(A) site and form the transcript terminus. Although the findings presented in this manuscript are not surprising, they are new and contribute a missing piece to our knowledge of how the transcription machinery determines which poly(A) site to utilize at the end of genes.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

    This article has 3 authors:
    1. Mu Gao
    2. Davi Nakajima An
    3. Jeffrey Skolnick
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable contribution, the authors apply an artificial intelligence method to predict the three-dimensional structure of complexes of outer membrane proteins of the Gram-negative bacterium E. coli. Some of the cases presented are compelling, as they explain previously published biochemical data and/or reproduce existing structural data.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    This article has 12 authors:
    1. Matthew T Parker
    2. Beth K Soanes
    3. Jelena Kusakina
    4. Antoine Larrieu
    5. Katarzyna Knop
    6. Nisha Joy
    7. Friedrich Breidenbach
    8. Anna V Sherwood
    9. Geoffrey J Barton
    10. Sebastian M Fica
    11. Brendan H Davies
    12. Gordon G Simpson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important paper reporting that an adenosine methyltransferase in the model plant Arabidopsis functions to target a key RNA component of the spliceosome, as in fission yeast, and thereby contributes to intron recognition. By contrast, the authors report no major role for the methyltransferase in targeting mRNAs, as reported in previous studies in Arabidopsis. While some of the evidence is convincing, other evidence is incomplete. The conclusions that mRNAs are not a significant target and that specific intronic sequences define sensitivity to the methyltransferase require additional support.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. A cryogenic, coincident fluorescence, electron, and ion beam microscope

    This article has 16 authors:
    1. Daan B Boltje
    2. Jacob P Hoogenboom
    3. Arjen J Jakobi
    4. Grant J Jensen
    5. Caspar TH Jonker
    6. Max J Kaag
    7. Abraham J Koster
    8. Mart GF Last
    9. Cecilia de Agrela Pinto
    10. Jürgen M Plitzko
    11. Stefan Raunser
    12. Sebastian Tacke
    13. Zhexin Wang
    14. Ernest B van der Wee
    15. Roger Wepf
    16. Sander den Hoedt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper is of particular interest to researchers who plan to use focused-ion beam scanning electron microscopes (FIB-SEMs) and require fluorescent data to guide the milling process. The authors describe a valuable after-market upgrade that allows fluorescent data acquisition during FIB-milling without stage repositioning. Technical details of the fluorescent module upgrade together with the sample stage redesign are compellingly documented and will enhance the implementation of this important technology.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy

    This article has 6 authors:
    1. Madeleine L. Ball
    2. Stefan A. Koestler
    3. Leila Muresan
    4. Sohaib Abdul Rehman
    5. Kevin O’Holleran
    6. Robert White

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

    This article has 6 authors:
    1. Stefan A Zukin
    2. Matthew R Marunde
    3. Irina K Popova
    4. Katarzyna M Soczek
    5. Eva Nogales
    6. Avinash B Patel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides insights into the architecture of the yeast histone acetyltransferase complex NuA4 and is of broad interest to those studying transcription and chromatin modification. The cryo-EM data are of very high quality, and enable the authors to devise a structural model that is in much better agreement with biochemical data than previously reported models. This structure represents an important puzzle piece towards a molecular understanding of chromatin modification.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

    This article has 9 authors:
    1. Yulong Qiao
    2. Qiang Sun
    3. Xiaona Chen
    4. Liangqiang He
    5. Di Wang
    6. Ruibao Su
    7. Yuanchao Xue
    8. Hao Sun
    9. Huating Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable study performing elegant experiments making identification of a specific regulator in skeletal muscle regeneration. It will form a foundation for further mechanistic investigation. The work is of importance in the clinical field of muscle injury and regeneration.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae

    This article has 5 authors:
    1. Thomas B. Bailey
    2. Phaedra A. Whitty
    3. Eric U. Selker
    4. Jeffrey. N. McKnight
    5. Laura E. McKnight

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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