1. ACE2-independent sarbecovirus cell entry is supported by TMPRSS2-related enzymes and reduces sensitivity to antibody-mediated neutralization

    This article has 17 authors:
    1. Lu Zhang
    2. Hsiu-Hsin Cheng
    3. Nadine Krüger
    4. Bojan Hörnich
    5. Luise Graichen
    6. Alexander S. Hahn
    7. Sebastian R. Schulz
    8. Hans-Martin Jäck
    9. Metodi V. Stankov
    10. Georg M.N. Behrens
    11. Marcel A. Müller
    12. Christian Drosten
    13. Onnen Mörer
    14. Martin Sebastian Winkler
    15. ZhaoHui Qian
    16. Stefan Pöhlmann
    17. Markus Hoffmann

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Multi-protein chimeric antigens, a novel combined approach for efficiently targeting and blocking the blood stage of Plasmodium falciparum

    This article has 5 authors:
    1. Bhagyashree Deshmukh
    2. Dhruv Khatri
    3. Sanjay Kumar Kochar
    4. Chaitanya Athale
    5. Krishanpal Karmodiya

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II

    This article has 14 authors:
    1. Raphael Vidal
    2. Eoin Leen
    3. Steffi Herold
    4. Mareike Müller
    5. Daniel Fleischhauer
    6. Christina Schülein-Völk
    7. Dimitrios Papadopoulos
    8. Isabelle Röschert
    9. Leonie Uhl
    10. Carsten P Ade
    11. Peter Gallant
    12. Richard Bayliss
    13. Martin Eilers
    14. Gabriele Büchel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents the valuable finding that TFIIIC interacts with MYCN to regulate RNA polymerase II dynamics by dissecting its impact on 3D chromatin architecture. Authors provide convincing evidence that MYCN and TFIIIC show long-range chromatin contacts, and that the expression of each protein limits the function of the other. The notion emerges that TFIIIC helps MYCN to maintain output at promoters while decreasing less productive associations at larger more extensively connected chromatin hubs. The paper is of interest to molecular biologists working on MYCN-dependent regulation of gene expression.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

    This article has 18 authors:
    1. Ida Marie Boisen
    2. Nadia Krarup Knudsen
    3. John Erik Nielsen
    4. Ireen Kooij
    5. Mathilde Louise Bagger
    6. Jovana Kaludjerovic
    7. Peter J O’Shaughnessy
    8. Peter W Andrews
    9. Noriko Ide
    10. Birgitte Grønkær Toft
    11. Anders Juul
    12. Arnela Mehmedbašić
    13. Anne Jørgensen
    14. Lee B Smith
    15. Richard W Norman
    16. Ewa Rajpert-De Meyts
    17. Beate Lanske
    18. Martin Blomberg Jensen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study reports data showing the link between a disruption in testicular mineral (phosphate) homeostasis, FGF23 expression, and Sertoli cell dysfunction. The data supporting the conclusion remains incomplete. This work will be of interest to biomedical researchers working on testis biology and male infertility.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Comprehensive Phenotyping of Extracellular Vesicles in Blood of Healthy Humans – Insights into Cellular Origin and Biological Variability

    This article has 8 authors:
    1. Marija Holcar
    2. Ivica Marić
    3. Tobias Tertel
    4. Katja Goričar
    5. Urška Čegovnik Primožič
    6. Darko Černe
    7. Bernd Giebel
    8. Metka Lenassi

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Deciphering the actin structure-dependent preferential cooperative binding of cofilin

    This article has 6 authors:
    1. Kien Xuan Ngo
    2. Huong T Vu
    3. Kenichi Umeda
    4. Minh-Nhat Trinh
    5. Noriyuki Kodera
    6. Taro QP Uyeda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this manuscript the authors present high-speed atomic force microscopy (HSAFM) to analyze real-time structural changes in actin filaments induced by cofilin binding. This important study enhances our understanding of actin dynamics which plays a crucial role in a broad spectrum of cellular activities based on solid experimental evidence. Some technical questions, however, remain, making the data interpretation incomplete.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. The transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay

    This article has 11 authors:
    1. M Kelbert
    2. A Jordán-Pla
    3. L de-Miguel-Jiménez
    4. J García-Martínez
    5. M Selitrennik
    6. A Guterman
    7. N Henig
    8. S Granneman
    9. JE Pérez-Ortín
    10. S Chávez
    11. M Choder
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports that a transcription factor that stimulates mRNA synthesis can stabilize its target transcripts, possibly through co-transcriptional assembly and action in the cytoplasm. While the primary observation is solid, whether an association of Sfp1 with specific transcripts in the cytoplasm is the critical step in transcript stabilization is not entirely clear. If confirmed by independent means, the authors would have found a novel mechanistic link between mRNA synthesis and cytoplasmic mRNA stability for specific transcripts. Such a finding would be of broad interest to the field of molecular biology.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. RNA tertiary structure and conformational dynamics revealed by BASH MaP

    This article has 2 authors:
    1. Maxim Oleynikov
    2. Samie R Jaffrey
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work substantially advances our understanding of RNA structure analysis by introducing an innovative method that extends DMS probing to include guanosine residues, thereby enhancing our ability to detect complex tertiary interactions. The evidence supporting the conclusions is compelling, with detailed analyses demonstrating the method's capacity to differentiate structural contexts and improve RNA structure predictions. This work will be of broad interest to RNA structural biology, biochemistry, and biophysics researchers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

    This article has 5 authors:
    1. Thomas E Forman
    2. Marcin P Sajek
    3. Eric D Larson
    4. Neelanjan Mukherjee
    5. Katherine A Fantauzzo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental work provides new mechanistic insight into the regulation of PDGF signaling through splicing controls. The evidence is compelling to demonstrate the involvement of Srsf3, an RNA-binding protein, in this new mechanism. The work will be of broad interest to developmental biologists in general and molecular biologists/biochemists in the field of growth factor signaling and RNA splicing.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency

    This article has 1 author:
    1. Zach Hensel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This short manuscript uses mutation counts in phylogenies of millions of SARS-CoV-2 genomes to show that mutation rates systematically differ between regions that are paired or unpaired in the predicted RNA secondary structure of the viral genome. Such an effect of pairing state is not unexpected, but its systematic demonstration using millions of viral genomes is valuable and convincing.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity