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  1. SciScore for 10.1101/2022.05.06.490915: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Experimental Models: Organisms/Strains
    Amino acid sequences of the NendoU (Nsp15) orthologues of the following human coronaviruses were obtained from the database: SARS-CoV2; HCoV-229E; HCoV-NL63; HCoV-OC43; HCoV-HKU1.
    SARS-CoV2; HCoV-229E; HCoV-NL63; HCoV-OC43; HCoV-HKU1
    suggested: None
    Recombinant DNA
    DNA sequences encoding each protein were codon-optimized for bacterial expression, synthesized, and cloned into the pET28a expression plasmid as custom orders by GenScript Biotech.
    suggested: RRID:Addgene_139598)
    Software and Algorithms
    The following reagents were acquired from Fisher Scientific: 1 M Tris-HCl pH 7.0 stock solution, TCEP-HCl, MnCl2, beta-mercaptoethanol, NaCl.
    Fisher Scientific
    suggested: (Thermo Fisher Scientific, RRID:SCR_008452)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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