Microbiology

Nanoscale resolution of microbial fiber degradation in action

1. Meltem Tatli
2. Sarah Moraïs
3. Omar E Tovar-Herrera
4. Yannick J Bomble
5. Edward A Bayer
6. Ohad Medalia
7. Itzhak Mizrahi

• Curated by eLife

  Evaluation Summary:

  The premise behind this manuscript is timely and of interest to a broad scientific community working in the field of microbial recycling of cellulosic biomass. It provides a useful link between the occurrence and molecular aspects of the bacterial 'machinery' named cellulosome, and physiological traits of the same bacteria when grown on micro-crystalline cellulose. The key claims of the manuscript are well supported by the data, and the approaches used are thoughtful and rigorous.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Low immune response after 1.5 years of primary SARS-CoV-2 infection and Covishield vaccination lead to SARS-CoV-2 reinfection

1. Anita M. Shete
2. Deepak Y. Patil
3. Rima R. Sahay
4. Gajanan N. Sapkal
5. Gururaj R. Deshpande
6. Pragya D. Yadav

Reviewed by ScreenIT

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants

1. Isha M. Wilson
2. Meredith N. Frazier
3. Jian-Liang Li
4. Thomas A. Randall
5. Robin E. Stanley

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

1. Stéphanie Thébault
2. Nathalie Lejal
3. Alexis Dogliani
4. Amélie Donchet
5. Agathe Urvoas
6. Marie Valerio-Lepiniec
7. Muriel Lavie
8. Cécile Baronti
9. Franck Touret
10. Bruno Da Costa
11. Clara Bourgon
12. Audrey Fraysse
13. Audrey Saint-Albin-Deliot
14. Jessica Morel
15. Bernard Klonjkowski
16. Xavier de Lamballerie
17. Jean Dubuisson
18. Alain Roussel
19. Philippe Minard
20. Sophie Le Poder
21. Nicolas Meunier
22. Bernard Delmas

Reviewed by ScreenIT

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity

1. Bo Meng
2. Rawlings Datir
3. Jinwook Choi
4. Stephen Baker
5. Gordon Dougan
6. Christoph Hess
7. Nathalie Kingston
8. Paul J. Lehner
9. Paul A. Lyons
10. Nicholas J. Matheson
11. Willem H. Owehand
12. Caroline Saunders
13. Charlotte Summers
14. James E.D. Thaventhiran
15. Mark Toshner
16. Michael P. Weekes
17. Patrick Maxwell
18. Ashley Shaw
19. Ashlea Bucke
20. Jo Calder
21. Laura Canna
22. Jason Domingo
23. Anne Elmer
24. Stewart Fuller
25. Julie Harris
26. Sarah Hewitt
27. Jane Kennet
28. Sherly Jose
29. Jenny Kourampa
30. Anne Meadows
31. Criona O’Brien
32. Jane Price
33. Cherry Publico
34. Rebecca Rastall
35. Carla Ribeiro
36. Jane Rowlands
37. Valentina Ruffolo
38. Hugo Tordesillas
39. Ben Bullman
40. Benjamin J. Dunmore
41. Stuart Fawke
42. Stefan Gräf
43. Josh Hodgson
44. Christopher Huang
45. Kelvin Hunter
46. Emma Jones
47. Ekaterina Legchenko
48. Cecilia Matara
49. Jennifer Martin
50. Federica Mescia
51. Ciara O’Donnell
52. Linda Pointon
53. Joy Shih
54. Rachel Sutcliffe
55. Tobias Tilly
56. Carmen Treacy
57. Zhen Tong
58. Jennifer Wood
59. Marta Wylot
60. Ariana Betancourt
61. Georgie Bower
62. Chiara Cossetti
63. Aloka De Sa
64. Madeline Epping
65. Stuart Fawke
66. Nick Gleadall
67. Richard Grenfell
68. Andrew Hinch
69. Sarah Jackson
70. Isobel Jarvis
71. Ben Krishna
72. Francesca Nice
73. Ommar Omarjee
74. Marianne Perera
75. Martin Potts
76. Nathan Richoz
77. Veronika Romashova
78. Luca Stefanucci
79. Mateusz Strezlecki
80. Lori Turner
81. Eckart M.D.D. De Bie
82. Katherine Bunclark
83. Masa Josipovic
84. Michael Mackay
85. John Allison
86. Helen Butcher
87. Daniela Caputo
88. Debbie Clapham-Riley
89. Eleanor Dewhurst
90. Anita Furlong
91. Barbara Graves
92. Jennifer Gray
93. Tasmin Ivers
94. Emma Le Gresley
95. Rachel Linger
96. Sarah Meloy
97. Francesca Muldoon
98. Nigel Ovington
99. Sofia Papadia
100. Isabel Phelan
101. Hannah Stark
102. Kathleen E. Stirrups
103. Paul Townsend
104. Neil Walker
105. Jennifer Webster
106. Ingrid Scholtes
107. Sabine Hein
108. Rebecca King
109. John R. Bradley
110. Kenneth G.C. Smith
111. Joo Hyeon Lee
112. Ravindra K. Gupta

Reviewed by ScreenIT

WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae

1. Josué Flores-Kim
2. Genevieve S Dobihal
3. Thomas G Bernhardt
4. David Z Rudner

• Curated by eLife

  Evaluation Summary:

  This study explores autolysis regulation in the gram positive pathogen Streptococcus Pneumoniae and finds that the turnover of wall teichoic acids at the septum controls cell elongation. Specifically, a possible new enzyme WhyD regulates the level of wall teichoic acids (WTA) at the bacterial septum, limiting the number of WTA-associated autolysins such as LytA at division sites. The study provides new insights into the molecular interactions between enzymes that regulate PG-associated polymers and enzymes that hydrolyze to regulate cell morphogenesis. In principle, such regulation will also apply to other monoderm bacteria. This article will be of interest to microbiologists who are studying bacterial cell envelope dynamics. The experimental data support the conclusions drawn and the work provides tools, concepts and remaining questions to address that will be instrumental to understand the mechanism underpinning autolytic control.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

1. Kamal L. Nahas
2. Viv Connor
3. Katharina M. Scherer
4. Clemens F. Kaminski
5. Maria Harkiolaki
6. Colin M. Crump
7. Stephen C. Graham

Reviewed by Review Commons

The SARS-CoV-2 Cellular Receptor ACE2 is expressed in Oropharyngeal Cells and is modulated in vitro by the Bacterial Lysate Lantigen B

1. Caterina Pizzimenti
2. Antonella D’Agostino
3. Paola Pirrello
4. Alessia Ruiba
5. Giovanni Melioli

Reviewed by ScreenIT

Cell cycle independent role of cyclin D3 in host restriction of SARS-CoV-2 infection

1. Ravi K. Gupta
2. Petra Mlcochova

Reviewed by ScreenIT

ORF6 protein of SARS-CoV-2 inhibits TRIM25 mediated RIG-I ubiquitination to mitigate type I IFN induction

1. Oyahida Khatun
2. Mansi Sharma
3. Rohan Narayan
4. Shashank Tripathi

Reviewed by ScreenIT