Microbiology

The class XIV myosin of Toxoplasma gondii , TgMyoA, is druggable in an animal model of infection

1. Anne Kelsen
2. Robyn S Kent
3. Anne K Snyder
4. Eddie Wehri
5. Stephen J Bishop
6. Rachel V Stadler
7. Cameron Powell
8. Bruno Martorelli di Genova
9. Pramod K Rompikuntal
10. Martin J Boulanger
11. David M Warshaw
12. Nicholas J Westwood
13. Julia Schaletzky
14. Gary E Ward

Reviewed by Review Commons

Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis

1. Pierre Dupuy
2. Shreya Ghosh
3. Allison Fay
4. Oyindamola Adefisayo
5. Richa Gupta
6. Stewart Shuman
7. Michael S Glickman

• Curated by eLife

  eLife assessment

  This study uses a combination of compelling biochemical and genetic approaches to identify a highly mutagenic DNA polymerase, which drives a wide spectrum of mutations when overexpressed. The important findings advance the understanding of mutagenesis in mycobacteria. The work will be of interest to bacteriologists interested in mutagenesis and the emergence of drug resistance.

Reviewed by eLife

Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

1. Rohan S Wakade
2. Laura C Ristow
3. Melanie Wellington
4. Damian J Krysan

• Curated by eLife

  eLife assessment

  Candida morphogenesis is important for virulence. This study provides important new information as to how C. albicans regulates the switch from budding to hyphal morphology. Their results identify transcription factors involved in the process of hyphal morphogenesis in the host. The results are convincing and will be interesting to scientists in the fields of medical mycology and cell biology.

Reviewed by eLife

An optimal regulation of fluxes dictates microbial growth in and out of steady state

1. Griffin Chure
2. Jonas Cremer

• Curated by eLife

  eLife assessment

  This valuable study provides a synthesis of sector models for cellular resource partitioning in microbes, and shows how a simple flux balance model can quantitatively explain growth phenomena from numerous published experimental datasets. The study is overall convincing, although there are a few incomplete points regarding parameter values (justification and discussion of robustness). This work should be of interest to the microbial physiology community.

Reviewed by eLife

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

1. Abdirahman I Abdi
2. Fiona Achcar
3. Lauriane Sollelis
4. João Luiz Silva-Filho
5. Kioko Mwikali
6. Michelle Muthui
7. Shaban Mwangi
8. Hannah W Kimingi
9. Benedict Orindi
10. Cheryl Andisi Kivisi
11. Manon Alkema
12. Amrita Chandrasekar
13. Peter C Bull
14. Philip Bejon
15. Katarzyna Modrzynska
16. Teun Bousema
17. Matthias Marti

• Curated by eLife

  eLife assessment

  This valuable work provides insight into how Plasmodium falciparum optimises the balance between infection of the human host and investment in onward transmission to the mosquito. Based on the appropriate and validated methodology most of the results are convincing, nonetheless, some conclusions are incomplete and require further support.

Reviewed by eLife

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

1. Robert LeDesma
2. Brigitte Heller
3. Abhishek Biswas
4. Stephanie Maya
5. Stefania Gili
6. John Higgins
7. Alexander Ploss

• Curated by eLife

  eLife assessment

  The paper aims to provide structural and functional information on the hepatitis E virus replication complex. The study will be of interest to a broad number of people studying at virus replication, since the replication complex are targets for therapeutic interventions.

Reviewed by eLife

An IS-mediated, RecA-dependent, bet-hedging strategy in Burkholderia thailandensis

1. Lillian C Lowrey
2. Leslie A Kent
3. Bridgett M Rios
4. Angelica B Ocasio
5. Peggy A Cotter

• Curated by eLife

  eLife assessment

  This paper reports a bet hedging strategy in bacteria based on chromosomal duplications and rearrangements that confer advantages in certain growth conditions. The work is of fundamental importance for understanding the role of genetic and biological variation in bacteria. The experimental work is exceptionally strong and convincing. The paper will be of interest to a broad audience including bacteriologists, geneticists and evolutionary biologists.

Reviewed by eLife

Nanopore-based enrichment of antimicrobial resistance genes – a case-based study

1. Adrian Viehweger
2. Mike Marquet
3. Martin Hölzer
4. Nadine Dietze
5. Mathias W. Pletz
6. Christian Brandt

Reviewed by GigaByte

The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

1. Sophie L. Winter
2. Gonen Golani
3. Fabio Lolicato
4. Melina Vallbracht
5. Keerthihan Thiyagarajah
6. Samy Sid Ahmed
7. Christian Lüchtenborg
8. Oliver T. Fackler
9. Britta Brügger
10. Thomas Hoenen
11. Walter Nickel
12. Ulrich S. Schwarz
13. Petr Chlanda

Reviewed by Review Commons

Uptake-independent killing of macrophages by extracellular aggregates of Mycobacterium tuberculosis is ESX-1 and PDIM-dependent

1. Chiara Toniolo
2. Neeraj Dhar
3. John D. McKinney

Reviewed by Review Commons