1. Membrane binding properties of the cytoskeletal protein bactofilin

    This article has 10 authors:
    1. Ying Liu
    2. Rajani Karmakar
    3. Maria Billini
    4. Wieland Steinchen
    5. Saumyak Mukherjee
    6. Rogelio Hernández-Tamayo
    7. Thomas Heimerl
    8. Gert Bange
    9. Lars V Schäfer
    10. Martin Thanbichler
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study advances our understanding of how bactofilin cytoskeletal proteins associate with cell membranes by identifying and characterizing a conserved membrane-targeting sequence. The evidence is solid, with a well-integrated combination of mutagenesis, biophysical analysis, molecular simulations, and bioinformatics supporting the mechanistic model. The work will be of particular interest to microbiologists and structural biologists studying bacterial cytoskeletons and membrane-protein interactions.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Magnesium depletion unleashes two unusual modes of colistin resistance with different fitness costs

    This article has 9 authors:
    1. Yu-Ying Phoebe Hsieh
    2. Ian P. O’Keefe
    3. Zeqi Wang
    4. Wanting Sun
    5. Hyojik Yang
    6. Linda M. Vu
    7. Robert K. Ernst
    8. Ajai A. Dandekar
    9. Harmit S. Malik

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    This article has 14 authors:
    1. Binayak Sarkar
    2. Jyotsna
    3. Mohit Yadav
    4. Priya Sharma
    5. Raman Deep Sharma
    6. Shweta Singh
    7. Aakash Chandramouli
    8. Kritee Mehdiratta
    9. Ashwani Kumar
    10. Siddhesh S Kamat
    11. Devram S Ghorpade
    12. Debasisa Mohanty
    13. Dhiraj Kumar
    14. Rajesh S Gokhale
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study examines infection of the liver and hepatocytes during tuberculosis infection. The authors convincingly demonstrate that aerosol infection of mice and guinea pigs leads to appreciable infection of the liver as well as the lung. A further strength of the study lies in clinical evaluation of the presence of tuberculosis bacteria in human autopsied liver samples from individuals with miliary tuberculosis and the presence of a clear granuloma-like structure, which will prompt further study.

    Reviewed by eLife, preLights

    This article has 11 evaluationsAppears in 2 listsLatest version Latest activity
  4. Viral commitment to infection depends on host metabolism

    This article has 4 authors:
    1. Anastasios Marantos
    2. Kim Sneppen
    3. Stanley Brown
    4. Namiko Mitarai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study shows the impact of the metabolic state of bacteria on phage infection. The experimental results, based on various phages infecting E. coli, are solid and consistent with a two-step adsorption mathematical model, although the detailed evidence supporting this model is currently incomplete. This study should be of interest to the communities working on cell metabolism and on host-pathogen interactions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Structure-guided secretome analysis of gall-forming microbes offers insights into effector diversity and evolution

    This article has 4 authors:
    1. Soham Mukhopadhyay
    2. Muhammad Asim Javed
    3. Jiaxu Wu
    4. Edel Pérez-López
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an important discovery regarding the diversity and evolution of gall-forming microbial effectors. Supported by convincing computational structural predictions and analyses, the research provides insights into the unique mechanisms by which gall-forming microbes exert their pathogenicity in plants. This study also offers guidance that is of value for future studies on pathogen effector function and co-evolution with host plants.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa

    This article has 20 authors:
    1. Roger-Junior Eloiflin
    2. Elena Pérez-Antón
    3. Aïssata Camara
    4. Annick Dujeancourt-Henry
    5. Salimatou Boiro
    6. Martial N’Djetchi
    7. Mélika Taoré
    8. Mathurin Koffi
    9. Dramane Kaba
    10. Yann Le Pennec
    11. Bakary Doukouré
    12. Abdoulaye Dansy Camara
    13. Moïse Kagbadouno
    14. Pascal Campagne
    15. Mamadou Camara
    16. Vincent Jamonneau
    17. Sophie Thevenon
    18. Jean-Mathieu Bart
    19. Lucy Glover
    20. Brice Rotureau
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports an advancement in the diagnosis of Animal African Trypanosomosis (AAT), which adapts a CRISPR-based diagnostic tool (SHERLOCK4AAT) to detect different trypanosome species responsible for AAT. The evidence supporting the conclusions is convincing and in line with the current state-of-the-art diagnostics. This study will be of interest to the fields of Epidemiology, Public Health, and Veterinary Medicine.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    This article has 10 authors:
    1. Nikol Kadeřábková
    2. R. Christopher D. Furniss
    3. Evgenia Maslova
    4. Lara Eisaiankhongi
    5. Patricia Bernal
    6. Alain Filloux
    7. Cristina Landeta
    8. Diego Gonzalez
    9. Ronan R. McCarthy
    10. Despoina A.I. Mavridou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study demonstrates that disruption of a common protein-folding system renders drug-resistant clinical bacteria susceptible to antibiotics. The work convincingly shows that targeting protein folding can be used to combat multidrug-resistant pathogens, both by potentiating the efficacy of existing drugs and by therapeutic use of small-molecule inhibitors. This study is significant and timely as it informs on a new strategy that is relevant to microbiologists and clinicians interested in combating antimicrobial resistance.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi

    This article has 9 authors:
    1. Faith Anderson Davis
    2. Kalpana Singh
    3. Joseph M. Krampen
    4. Jaidyn A Bryant
    5. Kyla S. Ost
    6. Shannon E. Righi
    7. Marcy J. Balunas
    8. Tuo Wang
    9. Teresa R. O’Meara

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. A rapid transfer of virions coated with heparan sulfate from the ECM to cell surface CD151 defines a step in the human papillomavirus infection cascade

    This article has 7 authors:
    1. Annika Massenberg
    2. Yahya Homsi
    3. Carl Niklas Schneider
    4. Snježana Mikuličić
    5. Tatjana Döring
    6. Luise Florin
    7. Thorsten Lang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study presents interesting observations on the potential importance of extracellular transport of human papillomaviruses along actin protrusions by retrograde flow. The focus on the events of HPV infection between ECM binding and keratinocyte-specific receptor binding is unique and interesting. However, the evidence supporting the conclusions is incomplete, and additional experimental support is needed. Because conclusions drawn regarding HS interactions are largely based on experiments using a single HS mAb, the specificity of this mAb needs to be described in more detail, either based on the literature or further experimentation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

    This article has 6 authors:
    1. Zhengyu Wu
    2. Maojin Tian
    3. Sanyuan Fu
    4. Min Chen
    5. Rongjing Zhang
    6. Junhua Yuan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study by Wu et al presents convincing data on bacterial cell organization, demonstrating that the two structures that account for bacterial motility - the chemotaxis complex and the flagella - colocalize to the same pole in Pseudomonas aeruginosa cells, and expose the regulation underlying their spatial organization and functioning. This manuscript will be of interest to cell biologists, primarily those studying bacteria.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
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