Microbiology

The vaccine candidate Liver Stage Antigen 3 is exported during Plasmodium falciparum infection and required for liver-stage development

1. Robyn McConville
2. Ryan WJ Steel
3. Matthew T O’Neill
4. Alan F Cowman
5. Norman Kneteman
6. Justin A Boddey

• Curated by eLife

  eLife Assessment

  This useful study provides new insights into the liver-stage antigen LSA3, its export to erythrocytes, and its role in liver-stage development. While the functional importance of LSA3 is well demonstrated, the data underlying the conclusions regarding antibody specificity, liver-stage localization, and phenotype remain incomplete. A key strength of the study is the use of mosquito and humanized mouse models to access life-cycle stages that are rarely studied in most laboratories.

Reviewed by eLife

Lysosomal activation in bladder epithelium enhances intracellular antibiotic clearance of uropathogenic Escherichia coli

1. Kathrin Tomasek
2. Kristina Skurvydaite
3. Gauri Paduthol
4. Allison M. Burns
5. Léa Schlunke
6. Valentin Borgeat
7. Christian Pasquali
8. Mario Romani
9. John D. McKinney

Reviewed by Review Commons

Identifying and targeting the Mg-Fe-PmrAB regulatory circuit reverses phosphate starvation-driven polymyxin resistance in Enterobacteriaceae

1. Guangming Zhang
2. Ziqing Deng
3. Jiezhang Jiang
4. Minji Wang
5. Xiaoyuan Wang
6. Xiaoyun Liu
7. Aixin Yan

• Curated by eLife

  eLife Assessment

  This study characterizes a potentially targetable mechanism by which phosphate scarcity drives polymyxin B resistance in Enterobacteriaceae. The findings are important. While some aspects of the approach are very strong, particularly the diversity of techniques, it is recommended to include genetic controls and antibiotic resistance experiments in order to strengthen the evidence, which is currently solid. The clarity and presentation of the findings could also be improved.

Reviewed by eLife