Microbiology

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

1. Deborah Maus
2. Elyzana Putrianti
3. Tobias Hoffmann
4. Michael Laue
5. Frank Seeber
6. Martin Blume

• Curated by eLife

  eLife Assessment

  This valuable study utilizes a newly developed approach to culture T gondii bradyzoites in myotubes, and then takes advantage of the antiparasitic compound collection known as the Pathogen Box, to find compounds that target both tachyzoite and bradyzoite forms of the parasite. A set of compounds yielding patterns consistent with targeting the mitochondrial bc1 complex was explored further, with solid evidence for changes in ATP production in bradyzoites to support the conclusions about the importance of this complex. The paper will be interesting for parasitologists studying drug discovery of apicomplexan parasites.

Reviewed by eLife

β-Coronaviruses use lysosomal organelles for cellular egress

1. S Ghosh
2. TA Dellibovi-Ragheb
3. E Pak
4. Q Qiu
5. M Fisher
6. PM Takvorian
7. C Bleck
8. V Hsu
9. AR Fehr
10. S Perlman
11. SR Achar
12. MR Straus
13. GR Whittaker
14. CAM de Haan
15. G Altan-Bonnet
16. N Altan-Bonnet

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

The riboflavin biosynthetic pathway as a novel target for antifungal drugs against Candida species

1. Jana Nysten
2. Arne Peetermans
3. Dries Vaneynde
4. Stef Jacobs
5. Liesbeth Demuyser
6. Patrick Van Dijck

Reviewed by Rapid Reviews Infectious Diseases

Immunoreactive peptide maps of SARS-CoV-2

1. Nischay Mishra
2. Xi Huang
3. Shreyas Joshi
4. Cheng Guo
5. James Ng
6. Riddhi Thakkar
7. Yongjian Wu
8. Xin Dong
9. Qianlin Li
10. Richard S. Pinapati
11. Eric Sullivan
12. Adrian Caciula
13. Rafal Tokarz
14. Thomas Briese
15. Jiahai Lu
16. W. Ian Lipkin

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Post-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimates

1. James D. Munday
2. Jolinda de Korne-Elenbaas
3. Charles Gan
4. Adrian Lison
5. Julien Riou
6. Christoph Ort
7. Timothy R. Julian
8. Tanja Stadler

Reviewed by Rapid Reviews Infectious Diseases

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infection

1. Anshula Sharma
2. Chandru Subramani
3. KA Shouri
4. Ghanshyam Sharma
5. Brohmomoy Basu
6. Abhay Deep Pandey
7. Archana Rout
8. Devendra Sharma
9. Deepti Jain
10. Sudhanshu Vrati

Reviewed by Rapid Reviews Infectious Diseases

Clinical Trypanosoma cruzi isolates share a common antigen repertoire that is absent from culture adapted strains

1. Jill M.C. Hakim
2. Sneider A.G. Guiterrez
3. Angel Duran
4. Edith Malaga-Machaca
5. Carolina Duque
6. Lulu Singer
7. Rony Colanzi
8. Jacqueline E. Sherbuk
9. Caryn Bern
10. Robert H. Gilman
11. Lousia A. Messenger
12. Monica R. Mugnier
13. Working Group on Chagas Disease in Bolivia and Peru

Reviewed by Rapid Reviews Infectious Diseases

AGPAT1 is a novel Chikungunya virus receptor on human cells

1. Brohmomoy Basu
2. Debapriyo Sarmadhikari
3. Shailendra Asthana
4. Manjula Kalia
5. Sudhanshu Vrati

Reviewed by Rapid Reviews Infectious Diseases

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo

1. Gregory Mathez
2. Paulo Jacob Silva
3. Vincent Carlen
4. Charlotte Deloizy
5. Clémentine Prompt
6. Anaïs Hubart
7. Joana Rocha-Pereira
8. Marie Galloux
9. Ronan Le Goffic
10. Francesco Stellacci
11. Valeria Cagno

Reviewed by Rapid Reviews Infectious Diseases

Identifying phage proteins that activate the bacterial innate immune system

1. Toni A. Nagy
2. Gina W. Gersabeck
3. Amy N. Conte
4. Aaron T. Whiteley

Reviewed by Rapid Reviews Infectious Diseases