1. The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics

    This article has 11 authors:
    1. Chrispin Chaguza
    2. Daan W Arends
    3. Stephanie W Lo
    4. Indri Hapsari Putri
    5. Anna York
    6. John A Lees
    7. Anne L Wyllie
    8. Daniel M Weinberger
    9. Stephen D Bentley
    10. Marien I de Jonge
    11. Amelieke JH Cremers
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that examines the impact of Streptococcus pneumoniae genetics on its in vitro growth kinetics, aiming to identify potential targets for vaccines and therapeutics. The study identified significant variations in growth characteristics among capsular serotypes and lineages, linked to phylogeny and high heritability, but genome-wide association studies did not reveal specific genomic loci associated with growth features independent of the genetic background. The evidence supporting these findings is convincing.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. RBMX2: A Pivotal Regulator Linking Mycobacterium bovis Infection to Epithelial-Mesenchymal Transition and Lung Cancer Progression

    This article has 13 authors:
    1. Chao Wang
    2. Yongchong Peng
    3. Hongxin Yang
    4. Yanzhu Jiang
    5. Abdul Karim Khalid
    6. Kailun Zhang
    7. Shengsong Xie
    8. Luiz Bermudez
    9. Yong Yang
    10. Lei Zhang
    11. Huanchun Chen
    12. Aizhen Guo
    13. Yingyu Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The identification of RBMX2 as a novel regulator linking mycobacterial infection to Epithelial-Mesenchymal Transition and cancer progression are fundamental findings that advance our understanding of a major research question about the link between infectious and non-infectious diseases, microbiology and oncology. It does so by introducing RBMX2 as a novel host factor, a potential therapeutic target and biomarker for both TB and lung cancer. The evidence provided is convincing because it is appropriate and the validated multi-omics methodologies used are in line with the current state of the art. This study will be of interest to scientists working in the fields of drug discovery, microbiology and oncology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Bacteria detect neutrophils via a system that responds to hypochlorous acid and flow

    This article has 11 authors:
    1. Ilona P Foik
    2. Runhang Shu
    3. Serena Abbondante
    4. Summer J Kasallis
    5. Lauren A Urban
    6. Andy P Huang
    7. Leora Duong
    8. Michaela E Marshall
    9. Eric Pearlman
    10. Timothy L Downing
    11. Albert Siryaporn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study reporting a new phenotype for a gene cluster that has previously been associated with the responses of the Gram-negative opportunistic pathogen Pseudomonas aeruginosa to flow fluid. Expression of the froABCD gene cluster is induced by HOCl in vitro and by activated immune cells, which produce these types of reactive chlorine species. Overall, the evidence presented by the authors is solid; however, the mechanism of fro-induction by HOCl remains unclear, and the evidence in support of the authors' claims is descriptive, which needs to be improved. This study is of interest to infection biologists interested in mechanisms of bacterial pathogenicity.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    This article has 2 authors:
    1. Junghoon Lee
    2. Scot P Ouellette
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, ectopic expression and knockdown strategies were used to assess the effects of increasing and decreasing Cyclic di-AMP on the developmental cycle in Chlamydia. The authors convincingly demonstrate that overexpression of the dacA-ybbR operon results in increased production of c-di-AMP and early expression of the transitionary gene hctA and late gene omcB. Whilst the authors have attempted to revise the submission, the model proposed in the revised manuscript is still not fully supported by the data presented.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  5. A novel mechanism for bacterial sporulation based on programmed peptidoglycan degradation

    This article has 9 authors:
    1. Carlos A Ramírez Carbó
    2. Oihane Irazoki
    3. Srutha Venkatesan
    4. Lauren JS Chen
    5. Haylie A Morales
    6. Assariel J Garcia Avila
    7. Hoi-Ling Cheung
    8. Felipe Cava
    9. Beiyan Nan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study identifies and partially characterises two proteins optimised for coordinated peptidoglycan degradation during two spore morphogenesis programs in the bacterium Myxococcus xanthus. The evidence supporting the conclusions is solid, although the description of the data is somewhat overstated. After some editing, the paper will be of interest to those studying peptidoglycan synthesis and reorganisation, which is a central aspect of microbial cell biology.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells

    This article has 4 authors:
    1. Léa Gaucherand
    2. Hugo Marie
    3. Julie Cremaschi
    4. Sébastien Pfeffer

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Phage-Encoded TelN Inhibits Mre11-Rad50 to Protect Hairpin Telomeres

    This article has 4 authors:
    1. Maya Houmel
    2. Nicolas Pellaton
    3. Anna Anchimiuk
    4. Stephan Gruber

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Membrane binding properties of the cytoskeletal protein bactofilin

    This article has 10 authors:
    1. Ying Liu
    2. Rajani Karmakar
    3. Maria Billini
    4. Wieland Steinchen
    5. Saumyak Mukherjee
    6. Rogelio Hernández-Tamayo
    7. Thomas Heimerl
    8. Gert Bange
    9. Lars V Schäfer
    10. Martin Thanbichler
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study advances our understanding of how bactofilin cytoskeletal proteins associate with cell membranes by identifying and characterizing a conserved membrane-targeting sequence. The evidence is solid, with a well-integrated combination of mutagenesis, biophysical analysis, molecular simulations, and bioinformatics supporting the mechanistic model. The work will be of particular interest to microbiologists and structural biologists studying bacterial cytoskeletons and membrane-protein interactions.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Magnesium depletion unleashes two unusual modes of colistin resistance with different fitness costs

    This article has 9 authors:
    1. Yu-Ying Phoebe Hsieh
    2. Ian P. O’Keefe
    3. Zeqi Wang
    4. Wanting Sun
    5. Hyojik Yang
    6. Linda M. Vu
    7. Robert K. Ernst
    8. Ajai A. Dandekar
    9. Harmit S. Malik

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    This article has 14 authors:
    1. Binayak Sarkar
    2. Jyotsna
    3. Mohit Yadav
    4. Priya Sharma
    5. Raman Deep Sharma
    6. Shweta Singh
    7. Aakash Chandramouli
    8. Kritee Mehdiratta
    9. Ashwani Kumar
    10. Siddhesh S Kamat
    11. Devram S Ghorpade
    12. Debasisa Mohanty
    13. Dhiraj Kumar
    14. Rajesh S Gokhale
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study examines infection of the liver and hepatocytes during tuberculosis infection. The authors convincingly demonstrate that aerosol infection of mice and guinea pigs leads to appreciable infection of the liver as well as the lung. A further strength of the study lies in clinical evaluation of the presence of tuberculosis bacteria in human autopsied liver samples from individuals with miliary tuberculosis and the presence of a clear granuloma-like structure, which will prompt further study.

    Reviewed by eLife, preLights

    This article has 11 evaluationsAppears in 2 listsLatest version Latest activity
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