Microbiology

A high-throughput, image-based assay to assess drug sensitivity of Acanthamoeba castellanii cysts

1. Carrie A. Flynn
2. Andrew Harmez
3. Rebecca I. Colón-Ríos
4. William F. Flynn
5. Barbara I. Kazmierczak

Reviewed by Arcadia Science

SIRT2 protects against Japanese encephalitis virus infection in mice

1. Perumal Arumugam Desingu
2. Lavanya Dindi
3. Krishnega Murugasamy
4. Ankit Kumar Tamta
5. Venketsubbu Ramasubbu
6. Sukanya Raghu
7. Amarjeet Shrama
8. Raju S Rajmani
9. Nagalingam R Sundaresan

• Curated by eLife

  eLife Assessment

  This important study explores the role of SIRT2 in regulating Japanese encephalitis virus replication and disease progression in rodent models. The findings presented are novel as sirtuins are known for their roles in aging, metabolism, and cell survival, but have not been studied in the context of viral infections until recently. The evidence supporting the claims is solid, although additional experiments to further characterize the clinical outcomes and directly test the link between acetylated NF-kB and SIRT2 expression would have strengthened the study. The work will be of interest to biologists studying viruses, sirtuins, and inflammation.

Reviewed by eLife

Flexibility and modulation of translation initiation in enterovirus genomes

1. Rhian L. O'Connor
2. Georgia M. Cook
3. Jacqueline Hankinson
4. Ksenia Fominykh
5. Samantha H. Cheng
6. Daniel A. Nash
7. Aurélie Cenier
8. Komal M. Nayak
9. Stephen C. Graham
10. Janet E. Deane
11. Matthias Zilbauer
12. Andrew E. Firth
13. Valeria Lulla

Reviewed by Review Commons

Azithromycin alters the microbiome composition, function and resistome in women with Chlamydia trachomatis infections

1. Sankhya Bommana
2. Olusola Olagoke
3. Yi-Juan Hu
4. Ruohong Wang
5. Mike Kama
6. Morgan Dehdashti
7. Reshma Kodimerla
8. Timothy D. Read
9. Deborah Dean

Reviewed by Rapid Reviews Infectious Diseases