1. Development of an Immunoassay for the Detection and Diagnosis of Microbially Influenced Corrosion Caused by Methanogenic Archaea

    This article has 2 authors:
    1. Sven Lahme
    2. Jorge Mantilla Aguas

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    This article has 3 authors:
    1. Benedikt M Mortzfeld
    2. Shakti K Bhattarai
    3. Vanni Bucci
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important advances in the discovery and assessment of microcins that improve our understanding of their prevalence and roles. The bioinformatics analysis, expression, and antimicrobial assays are solid, although the diverging evaluations also indicated the need for additional support regarding the sequence analysis and validation to fully back some of the claims and conclusions. This study will appeal to researchers working on the discovery and analysis of novel peptide natural products.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  3. A fast-acting inhibitor of blood-stage P. falciparum with mechanism distinct from artemisinin and chloroquine

    This article has 3 authors:
    1. Stephanie Kabeche
    2. Thomas Meister
    3. Ellen Yeh

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. A system for functional studies of the major virulence factor of malaria parasites

    This article has 18 authors:
    1. Jakob Cronshagen
    2. Johannes Allweier
    3. Paolo Mesén-Ramírez
    4. Jan Stäcker
    5. Anna Viktoria Vaaben
    6. Gala Ramón-Zamorano
    7. Isabel Naranjo-Prado
    8. Susann Ofori
    9. Pascal WTC Jansen
    10. Joëlle Hornebeck
    11. Florian Kieferle
    12. Agnes Murk
    13. Elicia Martin
    14. Carolina Castro-Peña
    15. Richárd Bártfai
    16. Thomas Lavstsen
    17. Iris Bruchhaus
    18. Tobias Spielmann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study introduces an important approach using selection linked integration (SLI) to generate Plasmodium falciparum lines expressing single, specific surface adhesins PfEMP1 variants, enabling precise study of PfEMP1 trafficking, receptor binding, and cytoadhesion. By moving the system to different parasite strains and introducing an advanced SLI2 system for additional genomic edits, this work provides compelling evidence for an innovative and rigorous platform to explore PfEMP1 biology and identify novel proteins essential for malaria pathogenesis including immune evasion.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

    This article has 8 authors:
    1. Ning Song
    2. Hang Gao
    3. Jianhao Li
    4. Yi Liu
    5. Mingze Wang
    6. Zhiming Ma
    7. Naisheng Zhang
    8. Wenlong Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study showing that age-related gut microbiota modulate uric acid metabolism through the NLRP3 inflammasome pathway and thereby regulate susceptibility to age-related gout. Several experimental approaches (mechanistic insights) and methods (data quality) remain incomplete. This paper should be of interest to researchers working on gout and microbiota.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  6. Virus adaptation to heparan sulfate comes with capsid stability tradeoff

    This article has 9 authors:
    1. Han Kang Tee
    2. Simon Crouzet
    3. Arunima Muliyil
    4. Gregory Mathez
    5. Valeria Cagno
    6. Matteo Dal Peraro
    7. Aleksandar Antanasijevic
    8. Sophie Clément
    9. Caroline Tapparel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important work and it correlates capsid stability with mutations that promote heparan sulfate binding. The data is solid, but there is a need for further analysis and experiments to support the claims and to propose a more detailed mechanism that could explain how these mutations altered capsid stability.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    This article has 13 authors:
    1. Iva Veseli
    2. Yiqun T Chen
    3. Matthew S Schechter
    4. Chiara Vanni
    5. Emily C Fogarty
    6. Andrea R Watson
    7. Bana Jabri
    8. Ran Blekhman
    9. Amy D Willis
    10. Michael K Yu
    11. Antonio Fernàndez-Guerra
    12. Jessika Füssel
    13. A Murat Eren
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an important new bioinformatics tool for normalizing gene copy number from metagenomic assemblies and applies it to gain functional insights into the loss of microbial diversity during conditions of stress. The inclusion of extensive computational validation makes this a compelling study that raises intriguing new hypotheses regarding the impact of disease states on the gut microbiome. This paper will likely be of broad interest to researchers studying the role of complex microbial communities in host health and disease.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

    This article has 5 authors:
    1. Francesca Torelli
    2. Diogo M da Fonseca
    3. Simon W Butterworth
    4. Joanna C Young
    5. Moritz Treeck
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows that Toxoplasma gondii uses paracrine mechanisms, in addition to cell-intrinsic methods, to evade the host immune system, with MYR1 playing a key role in transporting effector molecules into host cells. The authors present convincing evidence that in vivo, MYR1-deficient parasites can be rescued by wild-type parasites, revealing a limitation in pooled CRISPR screens, where such paracrine effects may obscure the identification of key parasite pathways involved in immune evasion

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Green synthesized silver nanoparticles from Moringa : Potential for preventative treatment of SARS-CoV-2 contaminated water

    This article has 16 authors:
    1. Adebayo J. Bello
    2. Omorilewa B. Ebunoluwa
    3. Rukayat O. Ayorinde
    4. Nneka Onyepeju
    5. Joseph O. Shaibu
    6. Adeniyi R. Adewole
    7. Abeebat O. Adewole
    8. Olusegun Adedeji
    9. Ololade O. Akinnusi
    10. Olajumoke B. Oladapo
    11. Temitope S. Popoola
    12. Oluwamodupe M. Arotiba
    13. Joseph B. Minari
    14. Luqman A. Adams
    15. Joy Okpuzor
    16. Mujeeb O. Shittu

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

    This article has 8 authors:
    1. Xin Ma
    2. Meng Li
    3. Yuanyuan Zhang
    4. Tingting Xu
    5. Xinchen Zhou
    6. Mengqi Qian
    7. Zhiren Yang
    8. Xinyan Han
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The work by Han and collaborators describes valuable findings on the role of Akkermansia muciniphila during ETEC infection. If confirmed, these findings will add to a growing list of beneficial properties of this organism. The strength of the evidence used to justify the conclusions in the manuscript is solid, as the analyses broadly support the claims with only minor weaknesses.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 17 of 246 Next