1. ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

    This article has 6 authors:
    1. Tejan Lodhiya
    2. Aseem Palande
    3. Anjali Veeram
    4. Gerald Larrouy-Maumus
    5. Dany JV Beste
    6. Raju Mukherjee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. The data are generally solid as the authors deploy multiple, orthogonal readouts and methods for manipulating reactive oxygen species and ATP. The work will be of interest to those studying antibiotic mechanisms of action.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 2 listsLatest version Latest activity
  2. Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    This article has 9 authors:
    1. Yajun Zhai
    2. Peiyi Liu
    3. Xueqin Hu
    4. Changjian Fan
    5. Xiaodie Cui
    6. Qibiao He
    7. Dandan He
    8. Xiaoyuan Ma
    9. Gongzheng Hu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study addresses the growing threat of multi-drug-resistant (MDR) pathogens by focusing on the enhanced efficacy of colistin when combined with artesunate and EDTA against colistin-resistant Salmonella strains. The evidence is solid, supported by comprehensive microbiological assays, molecular analyses, and in vivo experiments demonstrating the effectiveness of this synergic combination.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

    This article has 9 authors:
    1. Yuqian Wang
    2. Guibin Wang
    3. Lishan Zhang
    4. Qilan Cai
    5. Meizhen Lin
    6. Dongping Huang
    7. Yuyue Xie
    8. Wenxiong Lin
    9. Xiangmin Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors studied a novel Zn2+- and NAD+-independent KDAC protein, AhCobQ, in Aeromonas hydrophila, which lacks homology with eukaryotic counterparts, thus underscoring its unique evolutionary trajectory within the bacterial domain. They attempt to demonstrate deacetylase activity, however, whilst the revised manuscript has been improved, significant aspects of the data are still incomplete and require further refinement. The work will be of interest to microbiologists studying metabolism and post-translational modifications.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  4. MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

    This article has 12 authors:
    1. Ana Patrícia Graça
    2. Vadim Nikitushkin
    3. Mark Ellerhorst
    4. Cláudia Vilhena
    5. Tilman E Klassert
    6. Andreas Starick
    7. Malte Siemers
    8. Walid K Al-Jammal
    9. Ivan Vilotijevic
    10. Hortense Slevogt
    11. Kai Papenfort
    12. Gerald Lackner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Graca et al. reports a fundamental missing link in the ethanol metabolism of mycobacteria and illuminates the role of a flavoprotein dehydrogenase that acts as an electron shuttle between an uncommon redox cofactor and the electron transport chain. Overall, the data presented are compelling, supported by a range of well designed and meticulous experiments. The findings will be of broad interest to researchers investigating bacterial metabolism.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  5. Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

    This article has 9 authors:
    1. Meina He
    2. Yongxin Tao
    3. Kexin Mu
    4. Haoqi Feng
    5. Ying Fan
    6. Tong Liu
    7. Qiaoyun Huang
    8. Yujie Xiao
    9. Wenli Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Data presented in this useful report suggest a potentially new model for chemotaxis regulation in the gram-negative bacterium P. putida. Data supporting interactions between CheA and the copper-binding protein CsoR, reveal potential mechanisms for coordinating chemotaxis and copper resistance. There was, however, concern about the large number of CheA interactors identified in the initial screen and it was felt that the study was incomplete without a substantial number of additional experiments to test the model and bolster the authors' conclusions.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Validation of DXS as an attractive drug target in mycobacteria

    This article has 4 authors:
    1. T Maila
    2. M Nicolaai
    3. R.D Mbau
    4. G.T.M Mashabela

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study

    This article has 9 authors:
    1. Gillian AM Tarr
    2. Linda Chui
    3. Kim Stanford
    4. Emmanuel W Bumunang
    5. Rahat Zaheer
    6. Vincent Li
    7. Stephen B Freedman
    8. Chad R Laing
    9. Tim A McAllister
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study revealed numerous distinct lineages that evolved within a local human population in Alberta, Canada, leading to persistent cases of E. coli O157:H7 infections for over a decade and highlighting the ongoing involvement of local cattle in disease transmission, as well as the possibility of intermediate hosts and environmental reservoirs. This study also showed a shift towards more virulent stx2a-only strains becoming predominant in the local lineages. The evidence supporting the role played by cattle in the transmission system of human cases of E. coli O157:H7 in Alberta is solid.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity

    This article has 10 authors:
    1. Matias G. Perez
    2. Victoria Gillan
    3. William M. Anderson
    4. François Gerbe
    5. Fabien Herbert
    6. Tom N. McNeilly
    7. Rick M. Maizels
    8. Philippe Jay
    9. Eileen Devaney
    10. Collette Britton

    Reviewed by Arcadia Science

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Viro3D: a comprehensive database of virus protein structure predictions

    This article has 6 authors:
    1. Ulad Litvin
    2. Spyros Lytras
    3. Alexander Jack
    4. David L Robertson
    5. Joe Grove
    6. Joseph Hughes

    Reviewed by Arcadia Science

    This article has 21 evaluationsAppears in 1 listLatest version Latest activity
  10. Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression

    This article has 2 authors:
    1. Vandana Singh
    2. Scot P Ouellette
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors propose a model wherein the bacterial redox state plays a crucial role in the differentiation of Chlamydia trachomatis into elementary and reticulate bodies. They provide solid evidence to argue that a highly oxidising environment favours the formation of elementary bodies while a reducing condition slows down development. Overall, the study convincingly demonstrates that Chlamydial redox states play a role in differentiation, an observation that may have implications for the study of other bacterial systems.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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