Microbiology

Eukaryotes’ closest relatives are internally simple syntrophic archaea

1. Hiroyuki Imachi
2. Masaru K. Nobu
3. Shun’ichi Ishii
4. Yuga Hirakata
5. Tetsuro Ikuta
6. Yuta Isaji
7. Makoto Miyata
8. Masayuki Miyazaki
9. Yuki Morono
10. Kazuyoshi Murata
11. Satoshi Nakagawa
12. Miyuki Ogawara
13. Satoshi Okada
14. Yumi Saito
15. Sanae Sakai
16. Shigeru Shimamura
17. Yuhei O. Tahara
18. Yoshihiro Takaki
19. Yoshinori Takano
20. Eiji Tasumi
21. Katsuyuki Uematsu
22. Toshihiro Yoshimura
23. Ken Takai

Reviewed by Arcadia Science

Identification and Evaluation of Besifloxacin as Repurposed Antifungal Drug in Combination With Fluconazole Against Candida albicans

1. Shuvechha Chakraborty
2. Ameya Pawaskar
3. Siddhanath Metkari
4. Taruna Madan
5. Susan Idicula‐Thomas

Reviewed by PREreview

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo

1. Gregory Mathez
2. Paulo Jacob Silva
3. Vincent Carlen
4. Charlotte Deloizy
5. Clémentine Prompt
6. Anaïs Hubart
7. Joana Rocha-Pereira
8. Marie Galloux
9. Ronan Le Goffic
10. Francesco Stellacci
11. Valeria Cagno

Reviewed by Rapid Reviews Infectious Diseases

A connection between Vibrio cholerae motility and inter-animal transmission

1. Ian W Campbell
2. Ruchika Dehinwal
3. Alexander A. Morano
4. Katherine G. Dailey
5. Franz G. Zingl
6. Matthew K. Waldor

Reviewed by PREreview

Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa

1. Jiadai Huang
2. Yue Sun
3. Fang Chen
4. Shumin Li
5. Liangliang Han
6. Jingwei Li
7. Zhe He
8. Canfeng Hua
9. Chunyan Yao
10. Tianmin Li
11. Beifang Lu
12. Yung-Fu Chang
13. Xin Deng

• Curated by eLife

  eLife Assessment

  This study provides a valuable and comprehensive dataset on transcription factor binding in Pseudomonas aeruginosa, along with analyses of its regulatory network, key virulence and metabolic regulators, and a pangenomic examination of transcription factors. Utilizing large-scale ChIP-seq and multi-omics integration, the research convincingly supports the hierarchical regulatory structures and offers insights into virulence mechanisms. While further experimental validation is needed, this publicly accessible PATF_Net database enhances its utility for researchers investigating this significant pathogen associated with hospital infections and antibiotic resistance.

Reviewed by eLife

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

1. Sesh A. Sundararaman
2. Justin J. Miller
3. Ellora C. Daley
4. Kelsey A. O’Brien
5. Paulina Kasak
6. Abigail M. Daniels
7. Rachel L. Edwards
8. Kenneth M. Heidel
9. Darean A. Bague
10. Madeleine A. Wilson
11. Andrew J. Koelper
12. Elexi C. Kourtoglou
13. Alex D. White
14. Sloan A. August
15. Georgia A. Apple
16. Regis W. Rouamba
17. Anthony J. Durand
18. John J. Esteb
19. Florian L. Muller
20. R. Jeremy Johnson
21. Geoffrey C. Hoops
22. Cynthia S. Dowd
23. Audrey R. Odom John

Reviewed by Rapid Reviews Infectious Diseases

In vitro and in vivo synergy of Vancomycin and β-lactams against drug-resistant Mycobacterium tuberculosis and Non-tuberculous mycobacteria

1. Alok Kumar Singh
2. Pradip Malik
3. Atri Mukhopadhyay
4. Mohmmad Imran
5. Mohammad Naiyaz Ahmad
6. Juned Ali
7. Sangita Pramanik
8. Reetu Maindolia
9. Aditi Ghosh
10. Pratiksha Karaulia
11. Umesh D Gupta
12. Kalyan Mitra
13. Sidharth Chopra
14. Arunava Dasgupta

Reviewed by PREreview

Closest relatives of poxviruses are spread in the gut of humans and animals worldwide: the egoviruses

1. Morgan Gaïa
2. Hans-Joachim Ruscheweyh
3. A. Murat Eren
4. Eugene V. Koonin
5. Shinichi Sunagawa
6. Mart Krupovic
7. Tom O. Delmont

Reviewed by Arcadia Science

Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria

1. Sromona D Mukherjee
2. Carlos Batagello
3. Ava Adler
4. Jose Agudelo
5. Anna Zampini
6. Mangesh Suryavanshi
7. Andrew Nguyen
8. Terry Orr
9. Denise Dearing
10. Manoj Monga
11. Aaron W Miller

• Curated by eLife

  eLife Assessment

  This work presents a valuable approach based on a complex systems theoretical framework to characterize diet-host-microbe interactions and develop targeted bacteriotherapies through a three-phase workflow. Despite the partial support of the description and experimental setup of the 'complex systems theoretical approach,' the collected data are solid and advance our understanding of oxalate bacterial metabolism in microbial communities. This study will interest researchers working on gut microbiomes and the possible modulation of host-microbial interactions.

Reviewed by eLife

Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria

1. Yogita Kapoor
2. Himani Khurana
3. Debatri Dutta
4. Arnab Chakraborty
5. Anshu Priya
6. Archana Singh
7. Siddhesh S Kamat
8. Neeraj Dhar
9. Thomas John Pucadyil
10. Vinay Kumar Nandicoori

• Curated by eLife

  eLife Assessment

  Understanding bacterial growth mechanisms potentially uncover novel drug targets which are crucial for maintaining cellular viability, particularly for bacterial pathogens. In this important study, Kapoor et al, investigate the role of Wag31 in lipid and peptidoglycan biosynthesis in mycobacteria. A detailed analysis of Wag31 domain architecture revealed a role in membrane tethering. More specifically, the N-terminal and C-terminal domains appeared to have distinct functional roles. The data presented are solid and support the conclusion made. This study will be of broad interest to microbiologists and molecular biologists.

Reviewed by eLife