Microbiology

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

1. Lai Wei
2. Shuiqing Liu
3. Shanshan Lu
4. Shengdong Luo
5. Xiaoping An
6. Huahao Fan
7. Weiwei Chen
8. Erguang Li
9. Yigang Tong
10. Lihua Song

Reviewed by Rapid Reviews Infectious Diseases

Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

1. Supratim Pradhan
2. Dhruba Dhar
3. Debolina Manna
4. Shubhangi Chakraborty
5. Arkapriya Bhattacharyya
6. Khushi Chauhan
7. Rimi Mukherjee
8. Abhik Sen
9. Krishna Pandey
10. Soumen Das
11. Budhaditya Mukherjee

• Curated by eLife

  eLife Assessment

  This important study investigates the propensity of the intravacuolar pathogen, Leishmania, to scavenge lipids which it utilizes for its accelerated growth within macrophages. The authors present compelling evidence that supports this hypothesis, although the genetic basis for the parasite's requirement for lipids remains unresolved. The study adds to other work that has implicated pathogen-derived processes in the selective recruitment of vesicles to the pathogen-containing vacuole, based on the content of the cargo.

Reviewed by eLife

Single-dose VSV-Sudan virus vaccine protects from lethal Sudan virus infection within one week: a challenge study in macaques

1. Paige Fletcher
2. Kyle L. O’Donnell
3. Friederike Feldmann
4. Joseph F. Rhoderick
5. Chad S. Clancy
6. Cecilia A. Prator
7. Brian J. Smith
8. Bronwyn M. Gunn
9. Heinz Feldmann
10. Andrea Marzi

Reviewed by Rapid Reviews Infectious Diseases

The antifungal and other bioactive properties of the volatilome of Streptomyces scabiei

1. Nudzejma Stulanovic
2. Djulia Bensaada
3. Loïc Belde
4. Delphine Adam
5. Marc Hanikenne
6. Jean-François Focant
7. Pierre-Hugues Stefanuto
8. Sébastien Rigali

Reviewed by Arcadia Science

Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice

1. Qian Yu
2. Xiaotian Tang
3. Thomas Hart
4. Robert Homer
5. Alexia A Belperron
6. Linda K Bockenstedt
7. Aaron Ring
8. Akira Nakamura
9. Erol Fikrig

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the authors' claims is solid. However, several concerns raised by the reviewers remain unaddressed. This paper would be of interest to scientists in the infectious inflammatory disease field.

Reviewed by eLife

Implementation of a multiplex PCR amplfication system combined with next-generation genome sequencing to decipher the circulation of Human coronavirus 229E lineages in Southern France

1. Houmadi HIKMAT
2. Justine PY
3. Celine BOSCHI
4. Emilie BUREL
5. Lorlane LE TARGA
6. Matthieu MILLION
7. Lucile LESAGE
8. Aurelie MORAND
9. Bernard LA SCOLA
10. Philippe COLSON

Reviewed by PREreview

Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

1. Cheryll M Sia
2. Rebecca L Ambrose
3. Mary Valcanis
4. Patiyan Andersson
5. Susan A Ballard
6. Benjamin P Howden
7. Deborah A Williamson
8. Jaclyn S Pearson
9. Danielle J Ingle

• Curated by eLife

  eLife Assessment

  This study provides the most comprehensive analysis of Salmonella Dublin to date, uncovering distinct genotypic adaptations, antimicrobial resistance patterns, and virulence strategies that influence epidemiological success. The revised manuscript is very valuable, rigorous and compelling.

Reviewed by eLife

Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans

1. Catia Mota
2. Kiseung Kim
3. Ye Ji Son
4. Eun Jung Thak
5. Su-Bin Lee
6. Ju-El Kim
7. Jeong-Kee Yoon
8. Min-Ho Kang
9. Heeyoun Hwang
10. Yong-Sun Bahn
11. J Andrew Alspaugh
12. Hyun Ah Kang

• Curated by eLife

  eLife Assessment

  This important study confirms the molecular function of putative components of the N-glycan-dependent endoplasmic reticulum protein quality control (ERQC) system in the pathogen Cryptococcus neoformans. The study demonstrates an involvement in fitness, virulence, and the secretion and composition of extracellular vesicles, albeit in ways that are not yet fully understood. The evidence provided is convincing, with rigorous, well-controlled assays and the use of complemented strains.

Reviewed by eLife

SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

1. Li Tian
2. Zongzheng Zhao
3. Wenying Gao
4. Zirui Liu
5. Xiao Li
6. Wenyan Zhang
7. Zhaolong Li

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of how the SARS-CoV-2 Nsp16 protein is regulated by host E3 ligases to promote viral mRNA capping. Support for the overall claims in the revised manuscript is convincing . This work will be of interest to those working in host-viral interactions and the role of the ubiquitin-proteasome system in viral replication.

Reviewed by eLife

Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae

1. Bevika Sewgoolam
2. Kin Ki Jim
3. Vincent de Bakker
4. Florian P. Bock
5. Paddy Gibson
6. Jan-Willem Veening

Reviewed by Rapid Reviews Infectious Diseases