Microbiology

Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein

1. Hanora A. Van Ert
2. Dana W. Bohan
3. Kai Rogers
4. Mohammad Fili
5. Roberth A. Rojas Chávez
6. Enya Qing
7. Changze Han
8. Spencer Dempewolf
9. Guiping Hu
10. Nathan Schwery
11. Kristina Sevcik
12. Natalie Ruggio
13. Devlin Boyt
14. Michael A. Pentella
15. Tom Gallagher
16. J. Brooks Jackson
17. Anna E. Merrill
18. C. Michael Knudson
19. Grant D. Brown
20. Wendy Maury
21. Hillel Haim

Reviewed by ScreenIT

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

1. Alba Escalera
2. Ana S. Gonzalez-Reiche
3. Sadaf Aslam
4. Ignacio Mena
5. Rebecca L. Pearl
6. Manon Laporte
7. Andrea Fossati
8. Raveen Rathnasinghe
9. Hala Alshammary
10. Adriana van de Guchte
11. Mehdi Bouhaddou
12. Thomas Kehrer
13. Lorena Zuliani-Alvarez
14. David A. Meekins
15. Velmurugan Balaraman
16. Chester McDowell
17. Jürgen A. Richt
18. Goran Bajic
19. Emilia Mia Sordillo
20. Nevan Krogan
21. Viviana Simon
22. Randy A. Albrecht
23. Harm van Bakel
24. Adolfo Garcia-Sastre
25. Teresa Aydillo

Reviewed by ScreenIT

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

1. Shang Yu Gong
2. Debashree Chatterjee
3. Jonathan Richard
4. Jérémie Prévost
5. Alexandra Tauzin
6. Romain Gasser
7. Yuxia Bo
8. Dani Vézina
9. Guillaume Goyette
10. Gabrielle Gendron-Lepage
11. Halima Medjahed
12. Michel Roger
13. Marceline Côté
14. Andrés Finzi

Reviewed by ScreenIT

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

1. Alvin X Han
2. Zandra C Felix Garza
3. Matthijs RA Welkers
4. René M Vigeveno
5. Nhu Duong Tran
6. Thi Quynh Mai Le
7. Thai Pham Quang
8. Dinh Thoang Dang
9. Thi Ngoc Anh Tran
10. Manh Tuan Ha
11. Thanh Hung Nguyen
12. Quoc Thinh Le
13. Thanh Hai Le
14. Thi Bich Ngoc Hoang
15. Kulkanya Chokephaibulkit
16. Pilaipan Puthavathana
17. Van Vinh Chau Nguyen
18. My Ngoc Nghiem
19. Van Kinh Nguyen
20. Tuyet Trinh Dao
21. Tinh Hien Tran
22. Heiman FL Wertheim
23. Peter W Horby
24. Annette Fox
25. H Rogier van Doorn
26. Dirk Eggink
27. Menno D de Jong
28. Colin A Russell

• Curated by eLife

  Evaluation Summary:

  This work offers an in-depth exploration of within-host influenza evolution that helps untangle the process by which global trends arise from host-level dynamics. The manuscript will be of interest to virologists and evolutionary biologists alike, and the dataset provides a unique opportunity to explore evolutionary dynamics late in acute infections of both endemic and emerging viruses. Technical concerns relating to data interpretation and modeling assumptions suggest that some results might change after further investigation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 B.1.351 (beta) variant shows enhanced infectivity in K18-hACE2 transgenic mice and expanded tropism to wildtype mice compared to B.1 variant

1. Ferran Tarrés-Freixas
2. Benjamin Trinité
3. Anna Pons-Grífols
4. Miguel Romero-Durana
5. Eva Riveira-Muñoz
6. Carlos Ávila-Nieto
7. Mónica Pérez
8. Edurne Garcia-Vidal
9. Daniel Pérez-Zsolt
10. Jordana Muñoz-Basagoiti
11. Dàlia Raïch-Regué
12. Nuria Izquierdo-Useros
13. Ignacio Blanco
14. Marc Noguera-Julián
15. Victor Guallar
16. Rosalba Lepore
17. Alfonso Valencia
18. Júlia Vergara-Alert
19. Bonaventura Clotet
20. Ester Ballana
21. Jorge Carrillo
22. Joaquim Segalés
23. Julià Blanco

Reviewed by ScreenIT

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

1. Wenwei Li
2. Yaozong Chen
3. Jérémie Prévost
4. Irfan Ullah
5. Maolin Lu
6. Shang Yu Gong
7. Alexandra Tauzin
8. Romain Gasser
9. Dani Vézina
10. Sai Priya Anand
11. Guillaume Goyette
12. Debashree Chaterjee
13. Shilei Ding
14. William D. Tolbert
15. Michael W. Grunst
16. Yuxia Bo
17. Shijian Zhang
18. Jonathan Richard
19. Fei Zhou
20. Rick K. Huang
21. Lothar Esser
22. Allison Zeher
23. Marceline Côté
24. Priti Kumar
25. Joseph Sodroski
26. Di Xia
27. Pradeep D. Uchil
28. Marzena Pazgier
29. Andrés Finzi
30. Walther Mothes

Reviewed by ScreenIT

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

1. Ankur V Patel
2. Robert D Turner
3. Aline Rifflet
4. Adelina E Acosta-Martin
5. Andrew Nichols
6. Milena M Awad
7. Dena Lyras
8. Ivo Gomperts Boneca
9. Marshall Bern
10. Mark O Collins
11. Stéphane Mesnage

• Curated by eLife

  Evaluation Summary:

  This manuscript presents the development and validation of a new tool for the characterization of peptidoglycan (PG), the essential cell wall polymer of bacteria. PG is a single large macromolecule that protects almost all bacterial cells. The newly developed open access tool will greatly facilitate comparative quantitative analyses and the determination of compositional diversity of PG, which might ultimately contribute to the development of new antibacterials that target this essential cell wall component.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

1. Izumi Kimura
2. Yusuke Kosugi
3. Jiaqi Wu
4. Jiri Zahradnik
5. Daichi Yamasoba
6. Erika P. Butlertanaka
7. Yuri L. Tanaka
8. Keiya Uriu
9. Yafei Liu
10. Nanami Morizako
11. Kotaro Shirakawa
12. Yasuhiro Kazuma
13. Ryosuke Nomura
14. Yoshihito Horisawa
15. Kenzo Tokunaga
16. Takamasa Ueno
17. Akifumi Takaori-Kondo
18. Gideon Schreiber
19. Hisashi Arase
20. Chihiro Motozono
21. Akatsuki Saito
22. So Nakagawa
23. Kei Sato

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields

1. Yoichiro Fujioka
2. Sayaka Kashiwagi
3. Aiko Yoshida
4. Aya O. Satoh
5. Mari Fujioka
6. Maho Amano
7. Yohei Yamauchi
8. Yusuke Ohba

Reviewed by ScreenIT

SARS-CoV-2 in the Republic of Guinea: Fragment and Whole-Genome Sequencing, Phylogenetic Analysis

1. A.A. Kritsky
2. Ya.M. Krasnov
3. M. Keita
4. S. Keita
5. A.V. Fedorov
6. A.P. Shevtsova
7. N.P. Guseva
8. E.V. Kazorina
9. E.A. Sosedova
10. A.D. Katyshev
11. E.A. Naryshkina
12. E.V. Kolomoets
13. S.A. Shcherbakova
14. A.Yu. Popova
15. V.V. Kutyrev

Reviewed by ScreenIT