Microbiology

Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity

1. Abhishek Asthana
2. Christina Gaughan
3. Beihua Dong
4. Susan R. Weiss
5. Robert H. Silverman

Reviewed by ScreenIT

Nafamostat–Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2

1. Aleksandr Ianevski
2. Rouan Yao
3. Hilde Lysvand
4. Gunnveig Grødeland
5. Nicolas Legrand
6. Valentyn Oksenych
7. Eva Zusinaite
8. Tanel Tenson
9. Magnar Bjørås
10. Denis E. Kainov

Reviewed by ScreenIT

Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2

1. Lisa H. Tostanoski
2. Lisa E. Gralinski
3. David R. Martinez
4. Alexandra Schaefer
5. Shant H. Mahrokhian
6. Zhenfeng Li
7. Felix Nampanya
8. Huahua Wan
9. Jingyou Yu
10. Aiquan Chang
11. Jinyan Liu
12. Katherine McMahan
13. John D. Ventura
14. Kenneth H. Dinnon
15. Sarah R. Leist
16. Ralph S. Baric
17. Dan H. Barouch

Reviewed by ScreenIT

SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress

1. Katharina M. Scherer
2. Luca Mascheroni
3. George W. Carnell
4. Lucia C. S. Wunderlich
5. Stanislaw Makarchuk
6. Marius Brockhoff
7. Ioanna Mela
8. Ana Fernandez-Villegas
9. Max Barysevich
10. Hazel Stewart
11. Maria Suau Sans
12. Charlotte L. George
13. Jacob R. Lamb
14. Gabriele S. Kaminski-Schierle
15. Jonathan L. Heeney
16. Clemens F. Kaminski

Reviewed by ScreenIT

Phosphatidylserine receptors enhance SARS-CoV-2 infection

1. Dana Bohan
2. Hanora Van Ert
3. Natalie Ruggio
4. Kai J. Rogers
5. Mohammad Badreddine
6. José A. Aguilar Briseño
7. Jonah M. Elliff
8. Roberth Anthony Rojas Chavez
9. Boning Gao
10. Tomasz Stokowy
11. Eleni Christakou
12. Petri Kursula
13. David Micklem
14. Gro Gausdal
15. Hillel Haim
16. John Minna
17. James B. Lorens
18. Wendy Maury

Reviewed by ScreenIT

High efficacy of therapeutic equine hyperimmune antibodies against SARS-CoV-2 variants of concern

1. Andres Moreira-Soto
2. Mauricio Arguedas
3. Hebleen Brenes
4. Willem Buján
5. Eugenia Corrales-Aguilar
6. Cecilia Díaz
7. Ann Echeverri
8. Marietta Flores-Díaz
9. Aarón Gómez
10. Andrés Hernández
11. María Herrera
12. Guillermo León
13. Román Macaya
14. Arne Kühne
15. José Arturo Molina-Mora
16. Javier Mora
17. Alfredo Sanabria
18. Andrés Sánchez
19. Laura Sánchez
20. Álvaro Segura
21. Eduardo Segura
22. Daniela Solano
23. Claudio Soto
24. Jennifer L. Stynoski
25. Mariángela Vargas
26. Mauren Villalta
27. Chantal B E M Reusken
28. Christian Drosten
29. José María Gutiérrez
30. Alberto Alape-Girón
31. Jan Felix Drexler

Reviewed by ScreenIT

Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection

1. Bryan D. Griffin
2. Bryce M. Warner
3. Mable Chan
4. Emelissa J. Mendoza
5. Nikesh Tailor
6. Logan Banadyga
7. Anders Leung
8. Shihua He
9. Amrit S. Boese
10. Jonathan Audet
11. Wenguang Cao
12. Estella Moffat
13. Lauren Garnett
14. Kevin Tierney
15. Kaylie N. Tran
16. Alixandra Albietz
17. Kathy Manguiat
18. Geoff Soule
19. Alexander Bello
20. Robert Vendramelli
21. Jessica Lin
22. Yvon Deschambault
23. Wenjun Zhu
24. David Safronetz
25. Heidi Wood
26. Samira Mubareka
27. James E. Strong
28. Carissa Embury-Hyatt
29. Darwyn Kobasa

Reviewed by ScreenIT

Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

1. Peter J Diebold
2. Felicia N New
3. Michael Hovan
4. Michael J Satlin
5. Ilana L Brito

• Curated by eLife

  Evaluation Summary:

  Tracking horizontal gene transfer of mobile resistance genes is exceptionally important in the context of AMR and its burden on public health. An accessible high-throughput technique that provides an alternative to Hi-C or single-cell whole genome sequencing for associating mobile antibiotic resistance genes with their bacterial hosts in complex microbial populations is an important development for the field. The method introduced here, which relies on cellular emulsion and fusion PCR in one step, is an improvement over the previously published epicPCR. In addition, the method can be applied to other studies on complex microbial communities beyond antibiotic resistance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

1. K. Rosenke
2. F. Feldmann
3. A. Okumura
4. F. Hansen
5. T. Tang-Huau
6. K. Meade-White
7. B. Kaza
8. B.J. Smith
9. P. W. Hanley
10. J. Lovaglio
11. M. A. Jarvis
12. C. Shaia
13. H. Feldmann

Reviewed by ScreenIT

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

1. Michele Felletti
2. Cédric Romilly
3. E Gerhart H Wagner
4. Kristina Jonas

Reviewed by Review Commons