Microbiology

  1. Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

    1. Qianyun Liu
    2. Chenguang Cai
    3. Yanyan Huang
    4. Li Zhou
    5. Yanbin Guan
    6. Shiying Fu
    7. Youyou Lin
    8. Ting Yang
    9. Nanyan Wan
    10. Fengzhi Zhang
    11. Qi Sun
    12. Ying Bai
    13. Yu Chen
    14. Xiaohua Liang
    15. Huan Yan
    16. Zhen Zhang
    17. Ke Lan
    18. Yu Chen
    19. Xiang Li
    20. Shin-Chen Hou
    21. Yi Xiong

    Reviewed by ScreenIT

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  2. Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

    1. Yang Liu
    2. Jianying Liu
    3. Bryan A. Johnson
    4. Hongjie Xia
    5. Zhiqiang Ku
    6. Craig Schindewolf
    7. Steven G. Widen
    8. Zhiqiang An
    9. Scott C. Weaver
    10. Vineet D. Menachery
    11. Xuping Xie
    12. Pei-Yong Shi

    Reviewed by ScreenIT

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  3. SARS-CoV-2 Spike Affinity and Dynamics Exclude the Strict Requirement of an Intermediate Host

    1. Matteo Castelli
    2. Luigi Scietti
    3. Nicola Clementi
    4. Mattia Cavallaro
    5. Silvia Faravelli
    6. Alberta Pinnola
    7. Elena Criscuolo
    8. Roberta Antonia Diotti
    9. Massimo Clementi
    10. Federico Forneris
    11. Nicasio Mancini

    Reviewed by ScreenIT

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  4. Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization

    1. Kofi K. Acheampong
    2. Dylan L. Schaff
    3. Benjamin L. Emert
    4. Jonathan Lake
    5. Sam Reffsin
    6. Emily K. Shea
    7. Courtney E. Comar
    8. Leslie A. Litzky
    9. Nigar A. Khurram
    10. Rebecca L. Linn
    11. Michael Feldman
    12. Susan R. Weiss
    13. Kathleen T. Montone
    14. Sara Cherry
    15. Sydney M. Shaffer

    Reviewed by ScreenIT

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  5. VPS29 Exerts Opposing Effects on Endocytic Viral Entry

    1. Daniel Poston
    2. Yiska Weisblum
    3. Alvaro Hobbs
    4. Paul D. Bieniasz

    Reviewed by ScreenIT

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  6. Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

    1. Francisco Díaz-Pascual
    2. Martin Lempp
    3. Kazuki Nosho
    4. Hannah Jeckel
    5. Jeanyoung K Jo
    6. Konstantin Neuhaus
    7. Raimo Hartmann
    8. Eric Jelli
    9. Mads Frederik Hansen
    10. Alexa Price-Whelan
    11. Lars EP Dietrich
    12. Hannes Link
    13. Knut Drescher

    • Curated by eLife

      Evaluation Summary:

      In this manuscript the authors use a combination of transcriptomics, metabolomics, and quantitative measurements of growth to characterize the temporal and spatial distribution of cells with different metabolic states within colony of biofilms of the model bacterium Escherichia coli. They show that within the biofilm cells performing different metabolic functions are distributed in different regions of the colonies, and propose a model where nutrient cross-feeding through the amino acid alanine explains the phenotypic heterogeneity observed within the biofilm. The findings reported have potential broad implications for thinking about the spatial structure of communities of all bacterial species.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Age-Related Susceptibility of Ferrets to SARS-CoV-2 Infection

    1. Mathias Martins
    2. Maureen H. V. Fernandes
    3. Lok R. Joshi
    4. Diego G. Diel

    Reviewed by ScreenIT

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  8. Identification of potent small molecule inhibitors of SARS-CoV-2 entry

    1. Sonia Mediouni
    2. Huihui Mou
    3. Yuka Otsuka
    4. Joseph Anthony Jablonski
    5. Robert Scott Adcock
    6. Lalit Batra
    7. Dong-Hoon Chung
    8. Christopher Rood
    9. Ian Mitchelle S. de Vera
    10. Ronald Rahaim Jr.
    11. Sultan Ullah
    12. Xuerong Yu
    13. Yulia A. Getmanenko
    14. Nicole M. Kennedy
    15. Chao Wang
    16. Tu-Trinh Nguyen
    17. Mitchell Hull
    18. Emily Chen
    19. Thomas D. Bannister
    20. Pierre Baillargeon
    21. Louis Scampavia
    22. Michael Farzan
    23. Susana T. Valente
    24. Timothy P. Spicer

    Reviewed by ScreenIT

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  9. CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva

    1. Enyia R. Anderson
    2. Edward I. Patterson
    3. Siobhan Richards
    4. Ana K. Pitol
    5. Thomas Edwards
    6. Dominic Wooding
    7. Kate Buist
    8. Alison Green
    9. Sayandip Mukherjee
    10. Michael Hoptroff
    11. Grant L. Hughes

    Reviewed by ScreenIT

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  10. Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

    1. Abdullah M. Syed
    2. Taha Y. Taha
    3. Takako Tabata
    4. Irene P. Chen
    5. Alison Ciling
    6. Mir M. Khalid
    7. Bharath Sreekumar
    8. Pei-Yi Chen
    9. Jennifer M. Hayashi
    10. Katarzyna M. Soczek
    11. Melanie Ott
    12. Jennifer A. Doudna

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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