Microbiology

Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice

1. David M Alvarado
2. Juhee Son
3. Larissa B Thackray
4. Maria Florencia Gomez Castro
5. Sarada Prasad
6. Xueyang Cui
7. Naomi M Sonnek
8. Michael S Diamond
9. Siyuan Ding
10. Matthew A Ciorba

Reviewed by ScreenIT

The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

1. Anubama Rajan
2. Ashley Morgan Weaver
3. Gina Marie Aloisio
4. Joseph Jelinski
5. Hannah L. Johnson
6. Susan F. Venable
7. Trevor McBride
8. Letisha Aideyan
9. Felipe-Andrés Piedra
10. Xunyan Ye
11. Ernestina Melicoff-Portillo
12. Malli Rama Kanthi Yerramilli
13. Xi-Lei Zeng
14. Michael A. Mancini
15. Fabio Stossi
16. Anthony W. Maresso
17. Shalaka A. Kotkar
18. Mary K. Estes
19. Sarah Blutt
20. Vasanthi Avadhanula
21. Pedro A. Piedra

Reviewed by ScreenIT

SARS-CoV-2 exposure in wild white-tailed deer ( Odocoileus virginianus )

1. Jeffrey C. Chandler
2. Sarah N. Bevins
3. Jeremy W. Ellis
4. Timothy J. Linder
5. Rachel M. Tell
6. Melinda Jenkins-Moore
7. J. Jeffrey Root
8. Julianna B. Lenoch
9. Suelee Robbe-Austerman
10. Thomas J. DeLiberto
11. Thomas Gidlewski
12. Mia Kim Torchetti
13. Susan A. Shriner

Reviewed by ScreenIT

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

1. Zhaowei Xu
2. Yang Li
3. Qing Lei
4. Likun Huang
5. Dan-yun Lai
6. Shu-juan Guo
7. He-wei Jiang
8. Hongyan Hou
9. Yun-xiao Zheng
10. Xue-ning Wang
11. Jiaoxiang Wu
12. Ming-liang Ma
13. Bo Zhang
14. Hong Chen
15. Caizheng Yu
16. Jun-biao Xue
17. Hai-nan Zhang
18. Huan Qi
19. Siqi Yu
20. Mingxi Lin
21. Yandi Zhang
22. Xiaosong Lin
23. Zongjie Yao
24. Huiming Sheng
25. Ziyong Sun
26. Feng Wang
27. Xionglin Fan
28. Sheng-ce Tao

Reviewed by ScreenIT

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

1. Hataf Khan
2. Helena Winstone
3. Jose M. Jimenez-Guardeño
4. Carl Graham
5. Katie J. Doores
6. Caroline Goujon
7. David A. Matthews
8. Andrew D. Davidson
9. Suzannah J. Rihn
10. Massimo Palmarini
11. Stuart J. D. Neil
12. Michael H. Malim

Reviewed by ScreenIT

Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

1. Takeshi Imai
2. Ryuta Tobe
3. Koji Honda
4. Mai Tanaka
5. Jun Kawamoto
6. Hisaaki Mihara

• Curated by eLife

  Evaluation Summary:

  This manuscript is of interest to microbiologists and protein biochemists who study biofilm formation, haem proteins, and cellular responses to extracellular oxidative stress. It proposes a mechanism for biofilm protection from reactive oxygen species (ROIs) through the examination of the Gram positive, Bacillus subtilis. The data support many of the conclusions of the paper and highlight the importance of cell surface-localized protein peroxidase activity for proper biofilm assembly in a model species. Further evidence is needed to fully support the proposed mechanisms.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation

1. Hongchen Shen
2. Zhe Zhou
3. Haihuan Wang
4. Jiahao Chen
5. Mengyang Zhang
6. Minghao Han
7. Yun Shen
8. Danmeng Shuai

Reviewed by ScreenIT

The Achilles’ heel of coronaviruses: targeting the 5’ Polyuridines tract of the antigenome to inhibit Mouse coronavirus-induced cell death

1. Hemayet Ullah
2. Saadyah Averick
3. Qiyi Tang

Reviewed by ScreenIT

Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines

1. Theron Gilliland
2. Yanan Liu
3. Rong Li
4. Matthew Dunn
5. Emily Cottle
6. Yutaka Terada
7. Zachary Ryckman
8. Maria Alcorn
9. Shauna Vasilatos
10. Jeneveve Lundy
11. Deanna Larson
12. Hua Wu
13. Thomas Luke
14. Christoph Bausch
15. Kristi Egland
16. Eddie Sullivan
17. Zhongde Wang
18. William B. Klimstra

Reviewed by ScreenIT

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

1. Anamaria Babosan
2. David Skurnik
3. Anaëlle Muggeo
4. Gerald B Pier
5. Zeynep Baharoglu
6. Thomas Jové
7. Marie-Cécile Ploy
8. Sophie Griveau
9. Fethi Bedioui
10. Sébastien Vergnolle
11. Sophie Moussalih
12. Christophe de Champs
13. Didier Mazel
14. Thomas Guillard

• Curated by eLife

  Evaluation Summary:

  This manuscript describes how a small plasmid containing a quinolone resistance determinant changes the cellular response to sub-inhibitory concentrations of Tobramycin. Authors have found that Escherichia coli cells carrying this plasmid undergo nitrosative stress mediated by two previously uncharacterized genes, which leads to induction of the SOS response, a well described stress response in bacteria. These findings are relevant for readers across the microbiology and genetics fields.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife