Microbiology

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

1. Wenwei Li
2. Yaozong Chen
3. Jérémie Prévost
4. Irfan Ullah
5. Maolin Lu
6. Shang Yu Gong
7. Alexandra Tauzin
8. Romain Gasser
9. Dani Vézina
10. Sai Priya Anand
11. Guillaume Goyette
12. Debashree Chaterjee
13. Shilei Ding
14. William D. Tolbert
15. Michael W. Grunst
16. Yuxia Bo
17. Shijian Zhang
18. Jonathan Richard
19. Fei Zhou
20. Rick K. Huang
21. Lothar Esser
22. Allison Zeher
23. Marceline Côté
24. Priti Kumar
25. Joseph Sodroski
26. Di Xia
27. Pradeep D. Uchil
28. Marzena Pazgier
29. Andrés Finzi
30. Walther Mothes

Reviewed by ScreenIT

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

1. Ankur V Patel
2. Robert D Turner
3. Aline Rifflet
4. Adelina E Acosta-Martin
5. Andrew Nichols
6. Milena M Awad
7. Dena Lyras
8. Ivo Gomperts Boneca
9. Marshall Bern
10. Mark O Collins
11. Stéphane Mesnage

• Curated by eLife

  Evaluation Summary:

  This manuscript presents the development and validation of a new tool for the characterization of peptidoglycan (PG), the essential cell wall polymer of bacteria. PG is a single large macromolecule that protects almost all bacterial cells. The newly developed open access tool will greatly facilitate comparative quantitative analyses and the determination of compositional diversity of PG, which might ultimately contribute to the development of new antibacterials that target this essential cell wall component.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

1. Izumi Kimura
2. Yusuke Kosugi
3. Jiaqi Wu
4. Jiri Zahradnik
5. Daichi Yamasoba
6. Erika P. Butlertanaka
7. Yuri L. Tanaka
8. Keiya Uriu
9. Yafei Liu
10. Nanami Morizako
11. Kotaro Shirakawa
12. Yasuhiro Kazuma
13. Ryosuke Nomura
14. Yoshihito Horisawa
15. Kenzo Tokunaga
16. Takamasa Ueno
17. Akifumi Takaori-Kondo
18. Gideon Schreiber
19. Hisashi Arase
20. Chihiro Motozono
21. Akatsuki Saito
22. So Nakagawa
23. Kei Sato

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields

1. Yoichiro Fujioka
2. Sayaka Kashiwagi
3. Aiko Yoshida
4. Aya O. Satoh
5. Mari Fujioka
6. Maho Amano
7. Yohei Yamauchi
8. Yusuke Ohba

Reviewed by ScreenIT

SARS-CoV-2 in the Republic of Guinea: Fragment and Whole-Genome Sequencing, Phylogenetic Analysis

1. A.A. Kritsky
2. Ya.M. Krasnov
3. M. Keita
4. S. Keita
5. A.V. Fedorov
6. A.P. Shevtsova
7. N.P. Guseva
8. E.V. Kazorina
9. E.A. Sosedova
10. A.D. Katyshev
11. E.A. Naryshkina
12. E.V. Kolomoets
13. S.A. Shcherbakova
14. A.Yu. Popova
15. V.V. Kutyrev

Reviewed by ScreenIT

Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2

1. Julia R. Port
2. Claude Kwe Yinda
3. Victoria A. Avanzato
4. Jonathan E. Schulz
5. Myndi G. Holbrook
6. Neeltje van Doremalen
7. Carl Shaia
8. Robert J. Fischer
9. Vincent J. Munster

Reviewed by ScreenIT

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition

1. Chanakha K. Navaratnarajah
2. David R. Pease
3. Peter J. Halfmann
4. Biruhalem Taye
5. Alison Barkhymer
6. Kyle G. Howell
7. Jon E. Charlesworth
8. Trace A. Christensen
9. Yoshihiro Kawaoka
10. Roberto Cattaneo
11. Jay W. Schneider

Reviewed by ScreenIT

Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice

1. David M Alvarado
2. Juhee Son
3. Larissa B Thackray
4. Maria Florencia Gomez Castro
5. Sarada Prasad
6. Xueyang Cui
7. Naomi M Sonnek
8. Michael S Diamond
9. Siyuan Ding
10. Matthew A Ciorba

Reviewed by ScreenIT

The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

1. Anubama Rajan
2. Ashley Morgan Weaver
3. Gina Marie Aloisio
4. Joseph Jelinski
5. Hannah L. Johnson
6. Susan F. Venable
7. Trevor McBride
8. Letisha Aideyan
9. Felipe-Andrés Piedra
10. Xunyan Ye
11. Ernestina Melicoff-Portillo
12. Malli Rama Kanthi Yerramilli
13. Xi-Lei Zeng
14. Michael A. Mancini
15. Fabio Stossi
16. Anthony W. Maresso
17. Shalaka A. Kotkar
18. Mary K. Estes
19. Sarah Blutt
20. Vasanthi Avadhanula
21. Pedro A. Piedra

Reviewed by ScreenIT

SARS-CoV-2 exposure in wild white-tailed deer ( Odocoileus virginianus )

1. Jeffrey C. Chandler
2. Sarah N. Bevins
3. Jeremy W. Ellis
4. Timothy J. Linder
5. Rachel M. Tell
6. Melinda Jenkins-Moore
7. J. Jeffrey Root
8. Julianna B. Lenoch
9. Suelee Robbe-Austerman
10. Thomas J. DeLiberto
11. Thomas Gidlewski
12. Mia Kim Torchetti
13. Susan A. Shriner

Reviewed by ScreenIT